POF1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POF1B_HUMAN
• UniProt AC: Q8WVV4
• Protein Name: Protein POF1B
• Gene Name: POF1B
• Organism: Homo sapiens (Human).
• Sequence Length: 589
• Subcellular Localization: Cell junction, tight junction .
• Protein Description: Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development..
• Protein Sequence: MSSSYWSETSSSSCGTQQLPEVLQCQPQHYHCYHQSSQAQQPPEKNVVYERVRTYSGPMNKVVQALDPFNSREVLSPLKTTSSYQNLVWSDHSQELHSPTLKISTCAPSTLHITQNTEQELHSPTVKLTTYPQTTIRKYVVQNPEQEPLSQFLRGSHFFPGNNVIYEKTIRKVEKLNTDQGCHPQAQCHHHIIQQPQVIHSAHWQQPDSSQQIQAITGNNPISTHIGNELCHSGSSQICEQVIIQDDGPEKLDPRYFGELLADLSRKNTDLYHCLLEHLQRIGGSKQDFESTDESEDIESLIPKGLSEFTKQQIRYILQMRGMSDKSLRLVLSTFSNIREELGHLQNDMTSLENDKMRLEKDLSFKDTQLKEYEELLASVRANNHQQQQGLQDSSSKCQALEENNLSLRHTLSDMEYRLKELEYCKRNLEQENQNLRMQVSETCTGPMLQAKMDEIGNHYTEMVKNLRMEKDREICRLRSQLNQYHKDVSKREGSCSDFQFKLHELTSLLEEKDSLIKRQSEELSKLRQEIYSSHNQPSTGGRTTITTKKYRTQYPILGLLYDDYEYIPPGSETQTIVIEKTEDKYTCP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	LQCQPQHYHCYHQSS HHCCCCCEEECCCCC	6.58	-
33	Phosphorylation	QPQHYHCYHQSSQAQ CCCCEEECCCCCCCC	6.92	-
49	Phosphorylation	PPEKNVVYERVRTYS CCCCCCCEEEEHHCC	8.17	-
54	Phosphorylation	VVYERVRTYSGPMNK CCEEEEHHCCCCHHH	21.12	23312004
55	Phosphorylation	VYERVRTYSGPMNKV CEEEEHHCCCCHHHH	10.89	26657352
56	Phosphorylation	YERVRTYSGPMNKVV EEEEHHCCCCHHHHH	35.49	26657352
71	Phosphorylation	QALDPFNSREVLSPL HHHCCCCCCHHCCCC	30.14	23090842
76	Phosphorylation	FNSREVLSPLKTTSS CCCCHHCCCCCCCCC	33.10	28355574
80	Phosphorylation	EVLSPLKTTSSYQNL HHCCCCCCCCCCCCC	39.32	23927012
81	Phosphorylation	VLSPLKTTSSYQNLV HCCCCCCCCCCCCCC	17.68	23927012
82	Phosphorylation	LSPLKTTSSYQNLVW CCCCCCCCCCCCCCC	32.07	25849741
83	Phosphorylation	SPLKTTSSYQNLVWS CCCCCCCCCCCCCCC	28.75	26657352
84	Phosphorylation	PLKTTSSYQNLVWSD CCCCCCCCCCCCCCC	10.94	23927012
90	Phosphorylation	SYQNLVWSDHSQELH CCCCCCCCCCCCCCC	20.26	26657352
93	Phosphorylation	NLVWSDHSQELHSPT CCCCCCCCCCCCCCC	30.27	26657352
98	Phosphorylation	DHSQELHSPTLKIST CCCCCCCCCCEEEEE	32.00	23927012
100	Phosphorylation	SQELHSPTLKISTCA CCCCCCCCEEEEECC	43.64	23927012
104	Phosphorylation	HSPTLKISTCAPSTL CCCCEEEEECCCCEE	18.82	27080861
105	Phosphorylation	SPTLKISTCAPSTLH CCCEEEEECCCCEEE	19.03	27080861
109	Phosphorylation	KISTCAPSTLHITQN EEEECCCCEEEEECC	25.69	30206219
110	Phosphorylation	ISTCAPSTLHITQNT EEECCCCEEEEECCC	22.69	30206219
114	Phosphorylation	APSTLHITQNTEQEL CCCEEEEECCCCCCC	12.67	30206219
117	Phosphorylation	TLHITQNTEQELHSP EEEEECCCCCCCCCC	29.27	26657352
123	Phosphorylation	NTEQELHSPTVKLTT CCCCCCCCCCEEEEE	34.59	25159151
125	Phosphorylation	EQELHSPTVKLTTYP CCCCCCCCEEEEECC	33.03	25159151
131	Phosphorylation	PTVKLTTYPQTTIRK CCEEEEECCCCCHHH	6.52	23312004
134	Phosphorylation	KLTTYPQTTIRKYVV EEEECCCCCHHHHHC	21.49	23312004
135	Phosphorylation	LTTYPQTTIRKYVVQ EEECCCCCHHHHHCC	17.34	23312004
138	Methylation	YPQTTIRKYVVQNPE CCCCCHHHHHCCCCC	38.25	23644510
139	Phosphorylation	PQTTIRKYVVQNPEQ CCCCHHHHHCCCCCC	8.94	-
156	Phosphorylation	LSQFLRGSHFFPGNN HHHHHCCCCCCCCCC	15.64	26657352
166	Phosphorylation	FPGNNVIYEKTIRKV CCCCCEEEHHHHHHH	13.69	28152594
169	Phosphorylation	NNVIYEKTIRKVEKL CCEEEHHHHHHHHHC	17.67	23312004
256	Phosphorylation	PEKLDPRYFGELLAD HHHCCHHHHHHHHHH	22.71	28450419
265	Phosphorylation	GELLADLSRKNTDLY HHHHHHHHHCCCHHH	41.58	21815630
272	Phosphorylation	SRKNTDLYHCLLEHL HHCCCHHHHHHHHHH	8.03	-
291	Phosphorylation	GSKQDFESTDESEDI CCHHHHCCCCCCHHH	40.95	26657352
292	Phosphorylation	SKQDFESTDESEDIE CHHHHCCCCCCHHHH	36.27	25278378
295	Phosphorylation	DFESTDESEDIESLI HHCCCCCCHHHHHHC	43.30	25278378
300	Phosphorylation	DESEDIESLIPKGLS CCCHHHHHHCCCCHH	31.75	25278378
307	Phosphorylation	SLIPKGLSEFTKQQI HHCCCCHHHHHHHHH	39.06	24719451
310	Phosphorylation	PKGLSEFTKQQIRYI CCCHHHHHHHHHHHH	24.72	24719451
316	Phosphorylation	FTKQQIRYILQMRGM HHHHHHHHHHHHCCC	13.96	24719451
333	Phosphorylation	KSLRLVLSTFSNIRE HHHHHHHHHHHHHHH	21.67	-
364	Phosphorylation	MRLEKDLSFKDTQLK HHHHHHCCCCHHHHH	40.14	26657352
368	Phosphorylation	KDLSFKDTQLKEYEE HHCCCCHHHHHHHHH	36.07	29449344
371	Ubiquitination	SFKDTQLKEYEELLA CCCHHHHHHHHHHHH	48.73	29967540
411	Phosphorylation	NNLSLRHTLSDMEYR CCCCHHHHHHHHHHH	22.86	27696853
413	Phosphorylation	LSLRHTLSDMEYRLK CCHHHHHHHHHHHHH	35.75	27696853
417	Phosphorylation	HTLSDMEYRLKELEY HHHHHHHHHHHHHHH	18.01	23312004
424	Phosphorylation	YRLKELEYCKRNLEQ HHHHHHHHHHHHHHH	18.85	20068231
480	Phosphorylation	REICRLRSQLNQYHK HHHHHHHHHHHHHHH	43.54	24719451
487	Ubiquitination	SQLNQYHKDVSKREG HHHHHHHHCHHHCCC	55.69	29967540
490	Phosphorylation	NQYHKDVSKREGSCS HHHHHCHHHCCCCCH	35.81	24719451
495	Phosphorylation	DVSKREGSCSDFQFK CHHHCCCCCHHHHHH	12.99	26657352
497	Phosphorylation	SKREGSCSDFQFKLH HHCCCCCHHHHHHHH	43.06	23312004
507	Phosphorylation	QFKLHELTSLLEEKD HHHHHHHHHHHHHHH	17.84	25627689
508	Phosphorylation	FKLHELTSLLEEKDS HHHHHHHHHHHHHHH	43.51	25159151
513	2-Hydroxyisobutyrylation	LTSLLEEKDSLIKRQ HHHHHHHHHHHHHHH	43.15	-
515	Phosphorylation	SLLEEKDSLIKRQSE HHHHHHHHHHHHHHH	42.96	24719451
532	Phosphorylation	SKLRQEIYSSHNQPS HHHHHHHHHHCCCCC	11.90	21945579
533	Phosphorylation	KLRQEIYSSHNQPST HHHHHHHHHCCCCCC	30.68	21945579
534	Phosphorylation	LRQEIYSSHNQPSTG HHHHHHHHCCCCCCC	14.97	21945579
539	Phosphorylation	YSSHNQPSTGGRTTI HHHCCCCCCCCCCEE	29.89	21945579
540	Phosphorylation	SSHNQPSTGGRTTIT HHCCCCCCCCCCEEE	50.79	21945579
544	Phosphorylation	QPSTGGRTTITTKKY CCCCCCCCEEECCCC	26.31	23312004
545	Phosphorylation	PSTGGRTTITTKKYR CCCCCCCEEECCCCC	18.24	23312004
553	Phosphorylation	ITTKKYRTQYPILGL EECCCCCCCCCEECE	29.39	-
562	Phosphorylation	YPILGLLYDDYEYIP CCEECEEECCCCCCC	16.29	-
565	Phosphorylation	LGLLYDDYEYIPPGS ECEEECCCCCCCCCC	14.03	-
567	Phosphorylation	LLYDDYEYIPPGSET EEECCCCCCCCCCCC	16.70	-
586	Phosphorylation	IEKTEDKYTCP---- EEECCCCCCCC----	26.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POF1B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POF1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POF1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGK2_HUMAN	PGK2	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442
IF1AX_HUMAN	EIF1AX	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 300604: Premature ovarian failure 2B (POF2B)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.