HUTH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HUTH_HUMAN
• UniProt AC: P42357
• Protein Name: Histidine ammonia-lyase
• Gene Name: HAL
• Organism: Homo sapiens (Human).
• Sequence Length: 657
• Protein Sequence: MPRYTVHVRGEWLAVPCQDAQLTVGWLGREAVRRYIKNKPDNGGFTSVDDAHFLVRRCKGLGLLDNEDRLEVALENNEFVEVVIEGDAMSPDFIPSQPEGVYLYSKYREPEKYIELDGDRLTTEDLVNLGKGRYKIKLTPTAEKRVQKSREVIDSIIKEKTVVYGITTGFGKFARTVIPINKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEMFNASCLPYVPEKGTVGASGDLAPLSHLALGLVGEGKMWSPKSGWADAKYVLEAHGLKPVILKPKEGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHALRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKNIITTELNSATDNPMVFANRGETVSGGNFHGEYPAKALDYLAIGIHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSENKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLEQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLQFLHKKSTKIPESEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Acetylation	HFLVRRCKGLGLLDN HHHHHHCCCCCCCCC	56.19	7428197
155	Phosphorylation	KSREVIDSIIKEKTV HHHHHHHHHHHHCEE	18.32	24719451
158	Acetylation	EVIDSIIKEKTVVYG HHHHHHHHHCEEEEE	52.03	20167786
160	Acetylation	IDSIIKEKTVVYGIT HHHHHHHCEEEEEEE	41.43	12655543
161	Phosphorylation	DSIIKEKTVVYGITT HHHHHHCEEEEEEEC	19.12	25072903
164	Phosphorylation	IKEKTVVYGITTGFG HHHCEEEEEEECCCC	9.85	25072903
167	Phosphorylation	KTVVYGITTGFGKFA CEEEEEEECCCCHHC	19.26	25072903
168	Phosphorylation	TVVYGITTGFGKFAR EEEEEEECCCCHHCC	28.70	25072903
176	Phosphorylation	GFGKFARTVIPINKL CCCHHCCEEEEHHHH	21.25	21406692
203	Phosphorylation	SGVGKPLSPERCRML CCCCCCCCHHHHHHH	32.99	24719451
222	Phosphorylation	INVLAKGYSGISLET HHHHHCCCCCCCHHH	11.74	-
223	Phosphorylation	NVLAKGYSGISLETL HHHHCCCCCCCHHHH	38.02	-
226	Phosphorylation	AKGYSGISLETLKQV HCCCCCCCHHHHHHH	24.55	-
254	Other	EKGTVGASGDLAPLS CCCCCCCCCCCHHHH	27.23	-
254	"2,3-didehydroalanine (Ser)"	EKGTVGASGDLAPLS CCCCCCCCCCCHHHH	27.23	-
275	Phosphorylation	VGEGKMWSPKSGWAD HCCCCCCCCCCCCCC	20.96	24719451
298	Ubiquitination	GLKPVILKPKEGLAL CCCCEEECCCCCEEE	42.81	-
337	Phosphorylation	ADIVAALTLEVLKGT HHHHHHHHHHHHCCC	19.02	21406692
396	Phosphorylation	DRVQDAYTLRCCPQV CCCCCCHHHCCCCCC	14.94	24719451
410	Phosphorylation	VHGVVNDTIAFVKNI CCCCCCHHHHHHHHH	14.70	-
419	Phosphorylation	AFVKNIITTELNSAT HHHHHHHHCCHHHCC	15.49	29978859
420	Phosphorylation	FVKNIITTELNSATD HHHHHHHCCHHHCCC	28.24	29978859
573	Phosphorylation	FLRPLKTTTPLEKVY HHCCCCCCCCHHHHH	25.48	26437602
631	Phosphorylation	RMEHIPESRPLSPTA CHHCCCCCCCCCCCH	33.57	28450419
635	Phosphorylation	IPESRPLSPTAFSLQ CCCCCCCCCCHHHHH	23.92	28450419
637	Phosphorylation	ESRPLSPTAFSLQFL CCCCCCCCHHHHHHH	36.64	22617229
648	Phosphorylation	LQFLHKKSTKIPESE HHHHHHCCCCCCCCC	39.47	26670566
649	Phosphorylation	QFLHKKSTKIPESED HHHHHCCCCCCCCCC	41.70	26670566

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HUTH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HUTH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HUTH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKHA3_HUMAN	PLEKHA3	physical	28514442
KCD16_HUMAN	KCTD16	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 235800: Histidinemia (HISTID)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00117: L-Histidine