KCD16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCD16_HUMAN
• UniProt AC: Q68DU8
• Protein Name: BTB/POZ domain-containing protein KCTD16
• Gene Name: KCTD16
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Subcellular Localization: Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane .
• Protein Description: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity)..
• Protein Sequence: MALSGNCSRYYPREQGSAVPNSFPEVVELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRDTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRLKREAEYFQLPDLVKLLTPDEIKQSPDEFCHSDFEDASQGSDTRICPPSSLLPADRKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDMLSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREPSRWSPSHCDCCCKNGKGDKEGESGTSCNDLSTSSCDSQSEASSPQETVICGPVTRQTNIQTLDRPIKKGPVQLIQQSEMRRKSDLLRTLTSGSRESNMSSKKKAVKEKLSIEEELEKCIQDFLKIKIPDRFPERKHPWQSELLRKYHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	SLLWKMFSPKRDTAN HHHHHHHCCCCCCHH	26.47	22210691
84	Phosphorylation	RDGFLFRYILDYLRD CCCHHHHHHHHHHHH	9.86	-
112	Phosphorylation	RLKREAEYFQLPDLV CCHHHHHHHCCCHHH	12.04	20068231
130	Phosphorylation	TPDEIKQSPDEFCHS CHHHHHCCCCHHCCC	29.35	27732954
137	Phosphorylation	SPDEFCHSDFEDASQ CCCHHCCCCCCCCCC	45.21	27732954
143	Phosphorylation	HSDFEDASQGSDTRI CCCCCCCCCCCCCEE	47.60	27732954
146	Phosphorylation	FEDASQGSDTRICPP CCCCCCCCCCEECCH	28.33	27732954
148	Phosphorylation	DASQGSDTRICPPSS CCCCCCCCEECCHHH	24.51	27732954
167	Phosphorylation	DRKWGFITVGYRGSC CCCCEEEEEEECCEE	12.96	-
170	Phosphorylation	WGFITVGYRGSCTLG CEEEEEEECCEECCC	13.89	-
185	Malonylation	REGQADAKFRRVPRI CCCCCCCCCCCCCEE	39.69	26320211
185	Ubiquitination	REGQADAKFRRVPRI CCCCCCCCCCCCCEE	39.69	21890473
231	Ubiquitination	SRFYLKFKHLERAFD HHHHHHHHHHHHHHH	45.77	-
357	Phosphorylation	PVQLIQQSEMRRKSD HHHHHCHHHHHHHHH	19.58	28857561
363	Phosphorylation	QSEMRRKSDLLRTLT HHHHHHHHHHHHHHH	31.51	22210691
370	Phosphorylation	SDLLRTLTSGSRESN HHHHHHHHHCCCCCC	30.35	-
373	Phosphorylation	LRTLTSGSRESNMSS HHHHHHCCCCCCCHH	32.42	22210691
376	Phosphorylation	LTSGSRESNMSSKKK HHHCCCCCCCHHHHH	36.40	-
379	Phosphorylation	GSRESNMSSKKKAVK CCCCCCCHHHHHHHH	43.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCD16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCD16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCD16_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KCD16_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.