PKHA3_HUMAN - dbPTM
PKHA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHA3_HUMAN
UniProt AC Q9HB20
Protein Name Pleckstrin homology domain-containing family A member 3
Gene Name PLEKHA3
Organism Homo sapiens (Human).
Sequence Length 300
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein .
Protein Description Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P)..
Protein Sequence MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
92UbiquitinationLVALGSSKACLTDTR
HHHHCCCCCCCCCCC		44.83-
109PhosphorylationKEKEISETSESLKTK
HHHHHHHCCHHHHHH		30.8825690035
196PhosphorylationHHPDPLVSPVSPSPV
CCCCCCCCCCCCCHH		27.5429523821
199PhosphorylationDPLVSPVSPSPVQMM
CCCCCCCCCCHHHHH		24.0429523821
201PhosphorylationLVSPVSPSPVQMMKR
CCCCCCCCHHHHHHH		30.1424719451
209PhosphorylationPVQMMKRSVSHPGSC
HHHHHHHCCCCCCCC		23.5825394399
211PhosphorylationQMMKRSVSHPGSCSS
HHHHHCCCCCCCCCC		25.8025159151
215PhosphorylationRSVSHPGSCSSERSS
HCCCCCCCCCCCCCC		18.4426552605
217PhosphorylationVSHPGSCSSERSSHS
CCCCCCCCCCCCCCC		36.6127251275
218PhosphorylationSHPGSCSSERSSHSI
CCCCCCCCCCCCCCC		41.1626552605
221PhosphorylationGSCSSERSSHSIKEP
CCCCCCCCCCCCCCC		28.4923927012
222PhosphorylationSCSSERSSHSIKEPV
CCCCCCCCCCCCCCH		27.7223927012
224PhosphorylationSSERSSHSIKEPVST
CCCCCCCCCCCCHHH		36.9923401153
226UbiquitinationERSSHSIKEPVSTLH
CCCCCCCCCCHHHHH		60.0124816145
230PhosphorylationHSIKEPVSTLHRLSQ
CCCCCCHHHHHHHHH		35.6528152594
231PhosphorylationSIKEPVSTLHRLSQR
CCCCCHHHHHHHHHH		27.1530266825
236PhosphorylationVSTLHRLSQRRRRTY
HHHHHHHHHHHHCCC		22.9230266825
242PhosphorylationLSQRRRRTYSDTDSC
HHHHHHCCCCCCCCC		26.0923927012
243PhosphorylationSQRRRRTYSDTDSCS
HHHHHCCCCCCCCCC		11.6123927012
244PhosphorylationQRRRRTYSDTDSCSD
HHHHCCCCCCCCCCC		33.1623401153
246PhosphorylationRRRTYSDTDSCSDIP
HHCCCCCCCCCCCCC		24.7123927012
248PhosphorylationRTYSDTDSCSDIPLE
CCCCCCCCCCCCCCC		20.0123927012
250PhosphorylationYSDTDSCSDIPLEDP
CCCCCCCCCCCCCCC		42.3923927012
264PhosphorylationPDRPVHCSKNTLNGD
CCCCCCCCCCCCCCC		17.6723403867
286UbiquitinationEESRLMAKKQSESED
HHHHHHHHHCCCCCC		37.0624816145
289PhosphorylationRLMAKKQSESEDTLP
HHHHHHCCCCCCCCC		52.5525159151
291PhosphorylationMAKKQSESEDTLPSF
HHHHCCCCCCCCCCC		46.1223927012
294PhosphorylationKQSESEDTLPSFSS-
HCCCCCCCCCCCCC-		36.2028450419
297PhosphorylationESEDTLPSFSS----
CCCCCCCCCCC----		40.6527251275
299PhosphorylationEDTLPSFSS------
CCCCCCCCC------		39.2028450419
300PhosphorylationDTLPSFSS-------
CCCCCCCC-------		42.0823403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PKHA3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHA3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-289, AND MASSSPECTROMETRY.

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