HERP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HERP2_HUMAN
• UniProt AC: Q9BSE4
• Protein Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
• Gene Name: HERPUD2
• Organism: Homo sapiens (Human).
• Sequence Length: 406
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Could be involved in the unfolded protein response (UPR) pathway..
• Protein Sequence: MDQSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCTSRTPPSSPKSSTNRESHEALASSSNSSSDHSGSTTPSSGQETLSLAVGSSSEGLRQRTLPQAQTDQAQSHQFPYVMQGNVDNQFPGQAAPPGFPVYPAFSPLQMLWWQQMYAHQYYMQYQAAVSAQATSNVNPTQPTTSQPLNLAHVPGEEPPPAPNLVAQENRPMNENVQMNAQGGPVLNEEDFNRDWLDWMYTFSRAAILLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGHQQAPNNNAEVNNDGQNANNLELEEMERLMDDGLEDESGEDGGEDASAIQRPGLMASAWSFITTFFTSLIPEGPPQVAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	SGMEIPVTLIIKAPN CCCCCCEEEEEECCC	13.59	22210691
45	Phosphorylation	KTHLSNVYPSKPLTK HHHHHHCCCCCCCCC	13.16	-
47	Phosphorylation	HLSNVYPSKPLTKDQ HHHHCCCCCCCCCCC	29.26	24719451
48	Ubiquitination	LSNVYPSKPLTKDQR HHHCCCCCCCCCCCE	39.27	-
51	Phosphorylation	VYPSKPLTKDQRLVY CCCCCCCCCCCEEEE	40.89	-
52	Ubiquitination	YPSKPLTKDQRLVYS CCCCCCCCCCEEEEC	60.59	-
79	Phosphorylation	ILRKQDEYHMVHLVC HHHHCCCCEEEEEEE	11.96	30108239
87	Phosphorylation	HMVHLVCTSRTPPSS EEEEEEEECCCCCCC	17.48	30108239
88	Phosphorylation	MVHLVCTSRTPPSSP EEEEEEECCCCCCCC	29.09	30108239
90	Phosphorylation	HLVCTSRTPPSSPKS EEEEECCCCCCCCCC	39.04	23927012
93	Phosphorylation	CTSRTPPSSPKSSTN EECCCCCCCCCCCCC	61.55	30576142
94	Phosphorylation	TSRTPPSSPKSSTNR ECCCCCCCCCCCCCH	41.96	30108239
97	Phosphorylation	TPPSSPKSSTNRESH CCCCCCCCCCCHHHH	45.86	26074081
98	Phosphorylation	PPSSPKSSTNRESHE CCCCCCCCCCHHHHH	35.51	26074081
99	Phosphorylation	PSSPKSSTNRESHEA CCCCCCCCCHHHHHH	45.44	26074081
137	Phosphorylation	LSLAVGSSSEGLRQR EEEEEECCCHHHHHC	26.87	24275569

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HERP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HERP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HERP2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HERP2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.