SRP14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRP14_HUMAN
• UniProt AC: P37108
• Protein Name: Signal recognition particle 14 kDa protein
• Gene Name: SRP14
• Organism: Homo sapiens (Human).
• Sequence Length: 136
• Subcellular Localization: Cytoplasm.
• Protein Description: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding..
• Protein Sequence: MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAPAAAATAPTTAATTAATAAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVLLESEQFLTEL --CCCCCHHHHHHHH	36.35	20071362
19	Ubiquitination	ELTRLFQKCRTSGSV HHHHHHHHHCCCCCE	20.53	27667366
19	Acetylation	ELTRLFQKCRTSGSV HHHHHHHHHCCCCCE	20.53	26051181
22	Phosphorylation	RLFQKCRTSGSVYIT HHHHHHCCCCCEEEE	47.08	28331001
23	Phosphorylation	LFQKCRTSGSVYITL HHHHHCCCCCEEEEE	15.09	28442448
25	Phosphorylation	QKCRTSGSVYITLKK HHHCCCCCEEEEEEE	16.12	28152594
26	Ubiquitination	KCRTSGSVYITLKKY HHCCCCCEEEEEEEE	4.58	23000965
27	Phosphorylation	CRTSGSVYITLKKYD HCCCCCEEEEEEEEC	7.01	25159151
29	Phosphorylation	TSGSVYITLKKYDGR CCCCEEEEEEEECCC	18.16	28152594
30	Ubiquitination	SGSVYITLKKYDGRT CCCEEEEEEEECCCC	3.06	23000965
31	Ubiquitination	GSVYITLKKYDGRTK CCEEEEEEEECCCCC	40.41	33845483
31	Acetylation	GSVYITLKKYDGRTK CCEEEEEEEECCCCC	40.41	25953088
31	2-Hydroxyisobutyrylation	GSVYITLKKYDGRTK CCEEEEEEEECCCCC	40.41	-
33	Phosphorylation	VYITLKKYDGRTKPI EEEEEEEECCCCCCC	23.26	24719451
37	Phosphorylation	LKKYDGRTKPIPKKG EEEECCCCCCCCCCC	46.86	24719451
38	Ubiquitination	KKYDGRTKPIPKKGT EEECCCCCCCCCCCE	39.32	22817900
42	Ubiquitination	GRTKPIPKKGTVEGF CCCCCCCCCCEECCC	65.63	22817900
43	Acetylation	RTKPIPKKGTVEGFE CCCCCCCCCEECCCC	55.23	26051181
43	Ubiquitination	RTKPIPKKGTVEGFE CCCCCCCCCEECCCC	55.23	21906983
45	Phosphorylation	KPIPKKGTVEGFEPA CCCCCCCEECCCCCC	25.02	28985074
47	Ubiquitination	IPKKGTVEGFEPADN CCCCCEECCCCCCCC	58.99	33845483
54	Ubiquitination	EGFEPADNKCLLRAT CCCCCCCCEEEEEEC	38.76	23503661
55	Acetylation	GFEPADNKCLLRATD CCCCCCCEEEEEECC	27.14	26822725
55	2-Hydroxyisobutyrylation	GFEPADNKCLLRATD CCCCCCCEEEEEECC	27.14	-
55	Malonylation	GFEPADNKCLLRATD CCCCCCCEEEEEECC	27.14	30639696
55	Ubiquitination	GFEPADNKCLLRATD CCCCCCCEEEEEECC	27.14	32015554
56	Glutathionylation	FEPADNKCLLRATDG CCCCCCEEEEEECCC	5.62	22555962
56	Ubiquitination	FEPADNKCLLRATDG CCCCCCEEEEEECCC	5.62	23503661
57	Ubiquitination	EPADNKCLLRATDGK CCCCCEEEEEECCCC	3.76	23503661
59	Ubiquitination	ADNKCLLRATDGKKK CCCEEEEEECCCCCE	23.61	21963094
64	Ubiquitination	LLRATDGKKKISTVV EEEECCCCCEEEEEE	54.42	29967540
65	Ubiquitination	LRATDGKKKISTVVS EEECCCCCEEEEEEC	61.95	29967540
66	Ubiquitination	RATDGKKKISTVVSS EECCCCCEEEEEECH	45.43	33845483
68	Phosphorylation	TDGKKKISTVVSSKE CCCCCEEEEEECHHH	24.83	28674419
74	Malonylation	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	26320211
74	Neddylation	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	32015554
74	2-Hydroxyisobutyrylation	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	-
74	Acetylation	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	26051181
74	Ubiquitination	ISTVVSSKEVNKFQM EEEEECHHHHCHHHH	59.17	23000965
78	Acetylation	VSSKEVNKFQMAYSN ECHHHHCHHHHHHHH	41.99	25953088
78	Ubiquitination	VSSKEVNKFQMAYSN ECHHHHCHHHHHHHH	41.99	23000965
81	Sulfoxidation	KEVNKFQMAYSNLLR HHHCHHHHHHHHHHH	4.21	30846556
83	Phosphorylation	VNKFQMAYSNLLRAN HCHHHHHHHHHHHHC	7.86	29523821
84	Phosphorylation	NKFQMAYSNLLRANM CHHHHHHHHHHHHCH	16.09	29523821
95	Ubiquitination	RANMDGLKKRDKKNK HHCHHHHHHHHHCCC	51.82	33845483
102	Ubiquitination	KKRDKKNKTKKTKAA HHHHHCCCCHHHHHH	71.28	23503661
104	Ubiquitination	RDKKNKTKKTKAAAA HHHCCCCHHHHHHHH	61.12	23503661
105	Ubiquitination	DKKNKTKKTKAAAAA HHCCCCHHHHHHHHH	61.56	23503661
105	Methylation	DKKNKTKKTKAAAAA HHCCCCHHHHHHHHH	61.56	-
106	Phosphorylation	KKNKTKKTKAAAAAA HCCCCHHHHHHHHHH	27.72	22964224
107	Ubiquitination	KNKTKKTKAAAAAAA CCCCHHHHHHHHHHH	44.93	21963094
107	Methylation	KNKTKKTKAAAAAAA CCCCHHHHHHHHHHH	44.93	23644510
122	Phosphorylation	AAPAAAATAPTTAAT HHHHHHHCCCCHHHH	28.57	25332170
125	Phosphorylation	AAAATAPTTAATTAA HHHHCCCCHHHHHHH	26.97	25332170
126	Phosphorylation	AAATAPTTAATTAAT HHHCCCCHHHHHHHH	17.15	25332170
133	O-linked_Glycosylation	TAATTAATAAQ---- HHHHHHHHHHC----	21.77	28510447
133	Phosphorylation	TAATTAATAAQ---- HHHHHHHHHHC----	21.77	24532841

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRP14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRP14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRP14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRRM2_HUMAN	SRRM2	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
AN32A_HUMAN	ANP32A	physical	22863883
IF4A3_HUMAN	EIF4A3	physical	22863883
IPO9_HUMAN	IPO9	physical	22863883
PDLI5_HUMAN	PDLIM5	physical	22863883
SAE1_HUMAN	SAE1	physical	22863883
SAE2_HUMAN	UBA2	physical	22863883
MK67I_HUMAN	NIFK	physical	26344197
NOLC1_HUMAN	NOLC1	physical	26344197
SRP68_HUMAN	SRP68	physical	26344197
SRP72_HUMAN	SRP72	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.