NCF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCF2_HUMAN
• UniProt AC: P19878
• Protein Name: Neutrophil cytosol factor 2
• Gene Name: NCF2
• Organism: Homo sapiens (Human).
• Sequence Length: 526
• Subcellular Localization: Cytoplasm.
• Protein Description: NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)..
• Protein Sequence: MSLVEAISLWNEGVLAADKKDWKGALDAFSAVQDPHSRICFNIGCMYTILKNMTEAEKAFTRSINRDKHLAVAYFQRGMLYYQTEKYDLAIKDLKEALIQLRGNQLIDYKILGLQFKLFACEVLYNIAFMYAKKEEWKKAEEQLALATSMKSEPRHSKIDKAMECVWKQKLYEPVVIPVGKLFRPNERQVAQLAKKDYLGKATVVASVVDQDSFSGFAPLQPQAAEPPPRPKTPEIFRALEGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQKQKEEPKEVKLSVPMPYTLKVHYKYTVVMKTQPGLPYSQVRDMVSKKLELRLEHTKLSYRPRDSNELVPLSEDSMKDAWGQVKNYCLTLWCENTVGDQGFPDEPKESEKADANNQTTEPQLKKGSQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGECKGKVGIFPKVFVEDCATTDLESTRREV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLVEAISL ------CCHHHHHHH	40.91	28857561
48	Phosphorylation	FNIGCMYTILKNMTE HHHHHHHHHHHCCHH	7.92	29759185
81	Phosphorylation	YFQRGMLYYQTEKYD HHHCCCHHHHHHCHH	5.66	26074081
82	Phosphorylation	FQRGMLYYQTEKYDL HHCCCHHHHHHCHHH	12.66	26074081
84	Phosphorylation	RGMLYYQTEKYDLAI CCCHHHHHHCHHHHH	20.51	26074081
87	Phosphorylation	LYYQTEKYDLAIKDL HHHHHHCHHHHHHHH	15.23	26074081
125	Phosphorylation	LFACEVLYNIAFMYA HHHHHHHHHHHHHHH	15.08	-
157	Phosphorylation	MKSEPRHSKIDKAME CCCCCCCHHHHHHHH	32.36	24719451
207	Phosphorylation	GKATVVASVVDQDSF CCEEEEEEEECCCCC	15.86	27080861
213	Phosphorylation	ASVVDQDSFSGFAPL EEEECCCCCCCCCCC	18.71	27080861
215	Phosphorylation	VVDQDSFSGFAPLQP EECCCCCCCCCCCCC	36.63	27080861
233	Phosphorylation	EPPPRPKTPEIFRAL CCCCCCCCHHHHHHH	28.92	23927012
279	Phosphorylation	KGNDNWATVMFNGQK ECCCCEEEEEECCCC	12.24	26074081
293	Phosphorylation	KGLVPCNYLEPVELR CCEEECCCEEEEEEE	21.11	26074081
311	Phosphorylation	QQQPQEESSPQSDIP CCCCCCCCCCCCCCC	46.71	28450419
312	Phosphorylation	QQPQEESSPQSDIPA CCCCCCCCCCCCCCC	30.18	26657352
315	Phosphorylation	QEESSPQSDIPAPPS CCCCCCCCCCCCCCC	40.67	28450419
332	Phosphorylation	APGRPQLSPGQKQKE CCCCCCCCCCCCCCC	23.03	25159151
347	Phosphorylation	EPKEVKLSVPMPYTL CCCCCEEECCCCEEE	20.61	28387310
352	Phosphorylation	KLSVPMPYTLKVHYK EEECCCCEEEEEEEE	20.60	28387310
353	Phosphorylation	LSVPMPYTLKVHYKY EECCCCEEEEEEEEE	17.77	26552605
358	Phosphorylation	PYTLKVHYKYTVVMK CEEEEEEEEEEEEEE	14.53	26552605
360	Phosphorylation	TLKVHYKYTVVMKTQ EEEEEEEEEEEEECC	9.52	26552605
361	Phosphorylation	LKVHYKYTVVMKTQP EEEEEEEEEEEECCC	11.50	26552605
372	Phosphorylation	KTQPGLPYSQVRDMV ECCCCCCHHHHHHHH	19.44	30631047
373	Phosphorylation	TQPGLPYSQVRDMVS CCCCCCHHHHHHHHH	21.91	20363803
393	Phosphorylation	RLEHTKLSYRPRDSN HHHCCCCCCCCCCCC	22.20	30108239
394	Phosphorylation	LEHTKLSYRPRDSNE HHCCCCCCCCCCCCC	34.76	30108239
399	Phosphorylation	LSYRPRDSNELVPLS CCCCCCCCCCCEECC	33.22	27732954
406	Phosphorylation	SNELVPLSEDSMKDA CCCCEECCCCHHHHH	33.03	23911959
409	Phosphorylation	LVPLSEDSMKDAWGQ CEECCCCHHHHHHHH	24.55	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
233	T	Phosphorylation	Kinase	MAPK1	P28482	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCF4_HUMAN	NCF4	physical	11893732
NCF1_HUMAN	NCF1	physical	11796733
NCF4_HUMAN	NCF4	physical	11796733
RAC1_HUMAN	RAC1	physical	9624165
RAC2_HUMAN	RAC2	physical	9624165
PRDX6_HUMAN	PRDX6	physical	12121978
RAC2_HUMAN	RAC2	physical	9642115
RAC1_HUMAN	RAC1	physical	9642115
CDC42_HUMAN	CDC42	physical	9642115
CY24A_HUMAN	CYBA	physical	11917128
CY24A_HUMAN	CYBA	physical	11733522
NCF1_HUMAN	NCF1	physical	12169629
RAC1_HUMAN	RAC1	physical	11090627
NCF4_HUMAN	NCF4	physical	11483497
TRAF4_HUMAN	TRAF4	physical	16052631
NCF4_HUMAN	NCF4	physical	12813044
GNAI1_HUMAN	GNAI1	physical	16782902
GNAI2_HUMAN	GNAI2	physical	16782902
GNAI3_HUMAN	GNAI3	physical	16782902
GBB1_HUMAN	GNB1	physical	16782902
NCF4_HUMAN	NCF4	physical	16782902
NCF1_HUMAN	NCF1	physical	16782902
RAC1_HUMAN	RAC1	physical	25301945
KIFA3_HUMAN	KIFAP3	physical	25416956
PA24A_HUMAN	PLA2G4A	physical	18765662
CAMP3_HUMAN	CAMSAP3	physical	28514442
PMGE_HUMAN	BPGM	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
TBCD4_HUMAN	TBC1D4	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 233710: Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00514: Dextromethorphan