KIFA3_HUMAN - dbPTM
KIFA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KIFA3_HUMAN
UniProt AC Q92845
Protein Name Kinesin-associated protein 3
Gene Name KIFAP3
Organism Homo sapiens (Human).
Sequence Length 792
Subcellular Localization
Protein Description Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity)..
Protein Sequence MQGEDARYLKRKVKGGNIDVHPSEKALIVHYEVEATILGEMGDPMLGERKECQKIIRLKSLNANTDITSLARKVVEECKLIHPSKLNEVEQLLYYLQNRRDSLSGKEKKEKSSKPKDPPPFEGMEIDEVANINDMDEYIELLYEDIPDKVRGSALILQLARNPDNLEELLLNETALGALARVLREDWKQSVELATNIIYIFFCFSSFSQFHGLITHYKIGALCMNIIDHELKRHELWQEELSKKKKAVDEDPENQTLRKDYEKTFKKYQGLVVKQEQLLRVALYLLLNLAEDTRTELKMRNKNIVHMLVKALDRDNFELLILVVSFLKKLSIFMENKNDMVEMDIVEKLVKMIPCEHEDLLNITLRLLLNLSFDTGLRNKMVQVGLLPKLTALLGNDNYKQIAMCVLYHISMDDRFKSMFAYTDCIPQLMKMLFECSDERIDLELISFCINLAANKRNVQLICEGNGLKMLMKRALKFKDPLLMKMIRNISQHDGPTKNLFIDYVGDLAAQISNDEEEEFVIECLGTLANLTIPDLDWELVLKEYKLVPYLKDKLKPGAAEDDLVLEVVIMIGTVSMDDSCAALLAKSGIIPALIELLNAQQEDDEFVCQIIYVFYQMVFHQATRDVIIKETQAPAYLIDLMHDKNNEIRKVCDNTLDIIAEYDEEWAKKIQSEKFRWHNSQWLEMVESRQMDESEQYLYGDDRIEPYIHEGDILERPDLFYNSDGLIASEGAISPDFFNDYHLQNGDVVGQHSFPGSLGMDGFGQPVGILGRPATAYGFRPDEPYYYGYGS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMQGEDARYLKRKVKG
CCCHHHHHHHHHCCC		20.4926074081
14UbiquitinationRYLKRKVKGGNIDVH
HHHHHHCCCCCCCCC		65.2223000965
15UbiquitinationYLKRKVKGGNIDVHP
HHHHHCCCCCCCCCC		37.0521890473
16 (in isoform 2)Phosphorylation-23.3925849741
19UbiquitinationKVKGGNIDVHPSEKA
HCCCCCCCCCCCCCE		36.3521890473
19UbiquitinationKVKGGNIDVHPSEKA
HCCCCCCCCCCCCCE		36.3523000965
20PhosphorylationVKGGNIDVHPSEKAL
CCCCCCCCCCCCCEE		6.7432645325
23PhosphorylationGNIDVHPSEKALIVH
CCCCCCCCCCEEEEE		36.5326074081
31PhosphorylationEKALIVHYEVEATIL
CCEEEEEEEEEEHHH		15.6926074081
35UbiquitinationIVHYEVEATILGEMG
EEEEEEEEHHHCCCC		12.7129967540
39UbiquitinationEVEATILGEMGDPML
EEEEHHHCCCCCCCC		20.9929967540
54UbiquitinationGERKECQKIIRLKSL
CCHHHHHHHHHHHHC		52.3223000965
59UbiquitinationCQKIIRLKSLNANTD
HHHHHHHHHCCCCCC		42.9423000965
60PhosphorylationQKIIRLKSLNANTDI
HHHHHHHHCCCCCCH		31.2929255136
65PhosphorylationLKSLNANTDITSLAR
HHHCCCCCCHHHHHH		26.7724114839
68PhosphorylationLNANTDITSLARKVV
CCCCCCHHHHHHHHH		22.0928102081
79UbiquitinationRKVVEECKLIHPSKL
HHHHHHCCCCCHHHC		54.4729967540
84PhosphorylationECKLIHPSKLNEVEQ
HCCCCCHHHCCHHHH		35.3030576142
85UbiquitinationCKLIHPSKLNEVEQL
CCCCCHHHCCHHHHH		60.84-
94PhosphorylationNEVEQLLYYLQNRRD
CHHHHHHHHHHHCHH		15.6623090842
95PhosphorylationEVEQLLYYLQNRRDS
HHHHHHHHHHHCHHH		11.2023090842
102PhosphorylationYLQNRRDSLSGKEKK
HHHHCHHHCCHHHHH		23.7122199227
104PhosphorylationQNRRDSLSGKEKKEK
HHCHHHCCHHHHHCC		52.3422199227
165UbiquitinationQLARNPDNLEELLLN
HHHHCCCCHHHHHHC		51.0829967540
181UbiquitinationTALGALARVLREDWK
HHHHHHHHHHHHHHH		28.9329967540
185UbiquitinationALARVLREDWKQSVE
HHHHHHHHHHHHHHH		65.1529967540
199UbiquitinationELATNIIYIFFCFSS
HHHHHHHHHHHHHCC		6.4629967540
203UbiquitinationNIIYIFFCFSSFSQF
HHHHHHHHHCCHHHH		1.9429967540
215UbiquitinationSQFHGLITHYKIGAL
HHHCCHHHHHHHHHH		24.9729967540
219UbiquitinationGLITHYKIGALCMNI
CHHHHHHHHHHHHHH		2.8429967540
223UbiquitinationHYKIGALCMNIIDHE
HHHHHHHHHHHHCHH		1.6229967540
243UbiquitinationLWQEELSKKKKAVDE
HHHHHHHHHHHCCCC		79.7329967540
246UbiquitinationEELSKKKKAVDEDPE
HHHHHHHHCCCCCCC		63.62-
259UbiquitinationPENQTLRKDYEKTFK
CCCCHHHHHHHHHHH		68.7129967540
263UbiquitinationTLRKDYEKTFKKYQG
HHHHHHHHHHHHHCC		53.7029967540
268PhosphorylationYEKTFKKYQGLVVKQ
HHHHHHHHCCCCCCH		14.3830622161
284PhosphorylationQLLRVALYLLLNLAE
HHHHHHHHHHHHHHC		5.88-
298AcetylationEDTRTELKMRNKNIV
CCHHHHHHHCCCCHH		29.5819667057
325PhosphorylationELLILVVSFLKKLSI
HHHHHHHHHHHHHHH		19.8524719451
337UbiquitinationLSIFMENKNDMVEMD
HHHHHCCCCCCCHHH		40.81-
364PhosphorylationHEDLLNITLRLLLNL
CHHHHHHHHHHHHHC		12.5424719451
395UbiquitinationPKLTALLGNDNYKQI
HHHHHHHCCCCHHHH		40.0523000965
399UbiquitinationALLGNDNYKQIAMCV
HHHCCCCHHHHHHHH		13.7223000965
401UbiquitinationLGNDNYKQIAMCVLY
HCCCCHHHHHHHHHH		20.5023000965
429UbiquitinationYTDCIPQLMKMLFEC
HHHHHHHHHHHHHHC		2.7523000965
433UbiquitinationIPQLMKMLFECSDER
HHHHHHHHHHCCCCC		2.4623000965
435UbiquitinationQLMKMLFECSDERID
HHHHHHHHCCCCCCC		29.2023000965
437UbiquitinationMKMLFECSDERIDLE
HHHHHHCCCCCCCHH		35.0023000965
439UbiquitinationMLFECSDERIDLELI
HHHHCCCCCCCHHHH		34.9323000965
468UbiquitinationLICEGNGLKMLMKRA
EEECCHHHHHHHHHH		3.2329967540
469UbiquitinationICEGNGLKMLMKRAL
EECCHHHHHHHHHHH		31.24-
473UbiquitinationNGLKMLMKRALKFKD
HHHHHHHHHHHCCCC		30.4723000965
477UbiquitinationMLMKRALKFKDPLLM
HHHHHHHCCCCHHHH		49.7523000965
479UbiquitinationMKRALKFKDPLLMKM
HHHHHCCCCHHHHHH		57.7723000965
479AcetylationMKRALKFKDPLLMKM
HHHHHCCCCHHHHHH		57.777962755
485UbiquitinationFKDPLLMKMIRNISQ
CCCHHHHHHHHHHHC		31.01-
485AcetylationFKDPLLMKMIRNISQ
CCCHHHHHHHHHHHC		31.017962767
502UbiquitinationGPTKNLFIDYVGDLA
CCCCCCEEHHHHHHH		4.1529967540
506UbiquitinationNLFIDYVGDLAAQIS
CCEEHHHHHHHHHCC		20.2729967540
546UbiquitinationELVLKEYKLVPYLKD
HHHHHHHCCHHHHHH		44.0629967540
567UbiquitinationAEDDLVLEVVIMIGT
CCCCCCEEEEEEEEC		27.5329967540
601UbiquitinationLIELLNAQQEDDEFV
HHHHHHCCCCCCHHH		46.2329967540
605UbiquitinationLNAQQEDDEFVCQII
HHCCCCCCHHHHHHH		50.9429967540
645UbiquitinationLIDLMHDKNNEIRKV
HHHHHHCCCCHHHHH		47.1729967540
651UbiquitinationDKNNEIRKVCDNTLD
CCCCHHHHHHHCHHH		53.53-
669UbiquitinationEYDEEWAKKIQSEKF
HCCHHHHHHHHHHHH		52.02-
670UbiquitinationYDEEWAKKIQSEKFR
CCHHHHHHHHHHHHC		37.93-
675UbiquitinationAKKIQSEKFRWHNSQ
HHHHHHHHHCCCCHH		45.54-
695PhosphorylationESRQMDESEQYLYGD
HHHCCCHHHHHHCCC		26.24-
786PhosphorylationGFRPDEPYYYGYGS-
CCCCCCCCCCCCCC-		13.7922817900
787PhosphorylationFRPDEPYYYGYGS--
CCCCCCCCCCCCC--		10.9224043423
788PhosphorylationRPDEPYYYGYGS---
CCCCCCCCCCCC---		9.6824043423
790PhosphorylationDEPYYYGYGS-----
CCCCCCCCCC-----		9.7024043423
792PhosphorylationPYYYGYGS-------
CCCCCCCC-------		28.6824043423
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KIFA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KIFA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KIFA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
APC_HUMANAPCphysical
11912492
SMC3_HUMANSMC3physical
9506951
PEX19_HUMANPEX19physical
21988832
KIF3A_HUMANKIF3Aphysical
26344197
NCF2_HUMANNCF2physical
21516116
CRBG1_HUMANAIM1physical
26496610
CO4A1_HUMANCOL4A1physical
26496610
DHX15_HUMANDHX15physical
26496610
GLGB_HUMANGBE1physical
26496610
IMA1_HUMANKPNA2physical
26496610
PSMD5_HUMANPSMD5physical
26496610
SON_HUMANSONphysical
26496610
TAF1_HUMANTAF1physical
26496610
TAF4_HUMANTAF4physical
26496610
TAF5_HUMANTAF5physical
26496610
TAF7_HUMANTAF7physical
26496610
SNUT1_HUMANSART1physical
26496610
PRP4_HUMANPRPF4physical
26496610
PRPF3_HUMANPRPF3physical
26496610
KIF3B_HUMANKIF3Bphysical
26496610
DDX23_HUMANDDX23physical
26496610
GCC2_HUMANGCC2physical
26496610
RUSC2_HUMANRUSC2physical
26496610
CE350_HUMANCEP350physical
26496610
MED24_HUMANMED24physical
26496610
HMGX4_HUMANHMGXB4physical
26496610
GILT_HUMANIFI30physical
26496610
KIF3A_HUMANKIF3Aphysical
26496610
EFR3A_HUMANEFR3Aphysical
26496610
ORC3_HUMANORC3physical
26496610
RBM22_HUMANRBM22physical
26496610
MUC13_HUMANMUC13physical
26496610
SYF1_HUMANXAB2physical
26496610
RBM26_HUMANRBM26physical
26496610
F192A_HUMANFAM192Aphysical
26496610
BUD13_HUMANBUD13physical
26496610
OSBL1_HUMANOSBPL1Aphysical
26496610
KIF3A_HUMANKIF3Aphysical
28514442
KIF3B_HUMANKIF3Bphysical
28514442
KIF3C_HUMANKIF3Cphysical
28514442
RAP1A_HUMANRAP1Aphysical
28514442
CCNY_HUMANCCNYphysical
28514442
ERIC5_HUMANERICH5physical
28514442
SRC_HUMANSRCphysical
28514442
GT2D1_HUMANGTF2IRD1physical
28514442
PAK2_HUMANPAK2physical
28514442
VAMP3_HUMANVAMP3physical
28514442
S10AD_HUMANS100A13physical
28514442
GNAQ_HUMANGNAQphysical
28514442
NEUM_HUMANGAP43physical
28514442
VPS25_HUMANVPS25physical
28514442
GNAO_HUMANGNAO1physical
28514442
RAP2A_HUMANRAP2Aphysical
28514442
YES_HUMANYES1physical
28514442
KIF3A_HUMANKIF3Aphysical
27173435
KIF3B_HUMANKIF3Bphysical
27173435
IQGA3_HUMANIQGAP3physical
27173435
RT25_HUMANMRPS25physical
27173435
CE170_HUMANCEP170physical
27173435
NHRF2_HUMANSLC9A3R2physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KIFA3_HUMAN

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Related Literatures of Post-Translational Modification

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