CRBG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRBG1_HUMAN
• UniProt AC: Q9Y4K1
• Protein Name: Beta/gamma crystallin domain-containing protein 1 {ECO:0000312|HGNC:HGNC:356}
• Gene Name: CRYBG1 {ECO:0000312|HGNC:HGNC:356}
• Organism: Homo sapiens (Human).
• Sequence Length: 1723
• Protein Description: May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton..
• Protein Sequence: MEKRSSGRRSGRRRGSQKSTDSPGADAELPESAARDDAVFDDEVAPNAASDNASAEKKVKSPRAALDGGVASAASPESKPSPGTKGQLRGESDRSKQPPPASSPTKRKGRSRALEAVPAPPASGPRAPAKESPPKRVPDPSPVTKGTAAESGEEAARAIPRELPVKSSSLLPEIKPEHKRGPLPNHFNGRAEGGRSRELGRAAGAPGASDADGLKPRNHFGVGRSTVTTKVTLPAKPKHVELNLKTPKNLDSLGNEHNPFSQPVHKGNTATKISLFENKRTNSSPRHTDIRGQRNTPASSKTFVGRAKLNLAKKAKEMEQPEKKVMPNSPQNGVLVKETAIETKVTVSEEEILPATRGMNGDSSENQALGPQPNQDDKADVQTDAGCLSEPVASALIPVKDHKLLEKEDSEAADSKSLVLENVTDTAQDIPTTVDTKDLPPTAMPKPQHTFSDSQSPAESSPGPSLSLSAPAPGDVPKDTCVQSPISSFPCTDLKVSENHKGCVLPVSRQNNEKMPLLELGGETTPPLSTERSPEAVGSECPSRVLVQVRSFVLPVESTQDVSSQVIPESSEVREVQLPTCHSNEPEVVSVASCAPPQEEVLGNEHSHCTAELAAKSGPQVIPPASEKTLPIQAQSQGSRTPLMAESSPTNSPSSGNHLATPQRPDQTVTNGQDSPASLLNISAGSDDSVFDSSSDMEKFTEIIKQMDSAVCMPMKRKKARMPNSPAPHFAMPPIHEDHLEKVFDPKVFTFGLGKKKESQPEMSPALHLMQNLDTKSKLRPKRASAEQSVLFKSLHTNTNGNSEPLVMPEINDKENRDVTNGGIKRSRLEKSALFSSLLSSLPQDKIFSPSVTSVNTMTTAFSTSQNGSLSQSSVSQPTTEGAPPCGLNKEQSNLLPDNSLKVFNFNSSSTSHSSLKSPSHMEKYPQKEKTKEDLDSRSNLHLPETKFSELSKLKNDDMEKANHIESVIKSNLPNCANSDTDFMGLFKSSRYDPSISFSGMSLSDTMTLRGSVQNKLNPRPGKVVIYSEPDVSEKCIEVFSDIQDCSSWSLSPVILIKVVRGCWILYEQPNFEGHSIPLEEGELELSGLWGIEDILERHEEAESDKPVVIGSIRHVVQDYRVSHIDLFTEPEGLGILSSYFDDTEEMQGFGVMQKTCSMKVHWGTWLIYEEPGFQGVPFILEPGEYPDLSFWDTEEAYIGSMRPLKMGGRKVEFPTDPKVVVYEKPFFEGKCVELETGMCSFVMEGGETEEATGDDHLPFTSVGSMKVLRGIWVAYEKPGFTGHQYLLEEGEYRDWKAWGGYNGELQSLRPILGDFSNAHMIMYSEKNFGSKGSSIDVLGIVANLKETGYGVKTQSINVLSGVWVAYENPDFTGEQYILDKGFYTSFEDWGGKNCKISSVQPICLDSFTGPRRRNQIHLFSEPQFQGHSQSFEETTSQIDDSFSTKSCRVSGGSWVVYDGENFTGNQYVLEEGHYPCLSAMGCPPGATFKSLRFIDVEFSEPTIILFEREDFKGKKIELNAETVNLRSLGFNTQIRSVQVIGGIWVTYEYGSYRGRQFLLSPAEVPNWYEFSGCRQIGSLRPFVQKRIYFRLRNKATGLFMSTNGNLEDLKLLRIQVMEDVGADDQIWIYQEGCIKCRIAEDCCLTIVGSLVTSGSKLGLALDQNADSQFWSLKSDGRIYSKLKPNLVLDIKGGTQYDQNHIILNTVSKEKFTQVWEAMVLYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	RSGRRRGSQKSTDSP CCCCCCCCCCCCCCC		23401153
19	Phosphorylation	RRRGSQKSTDSPGAD CCCCCCCCCCCCCCC		23401153
20	Phosphorylation	RRGSQKSTDSPGADA CCCCCCCCCCCCCCC		28355574
22	Phosphorylation	GSQKSTDSPGADAEL CCCCCCCCCCCCCCC		28355574
32	Phosphorylation	ADAELPESAARDDAV CCCCCCHHHHCCCCC		30576142
50	Phosphorylation	EVAPNAASDNASAEK CCCCCCCCCCCCHHH		23090842
54	Phosphorylation	NAASDNASAEKKVKS CCCCCCCCHHHHCCC		72242705
61	Phosphorylation	SAEKKVKSPRAALDG CHHHHCCCHHHHHCC		26074081
72	Phosphorylation	ALDGGVASAASPESK HHCCCCCCCCCCCCC		29255136
75	Phosphorylation	GGVASAASPESKPSP CCCCCCCCCCCCCCC		29255136
78	Phosphorylation	ASAASPESKPSPGTK CCCCCCCCCCCCCCC		29255136
81	Phosphorylation	ASPESKPSPGTKGQL CCCCCCCCCCCCCCC		28355574
84	Phosphorylation	ESKPSPGTKGQLRGE CCCCCCCCCCCCCCC		30278072
95	Phosphorylation	LRGESDRSKQPPPAS CCCCCCCCCCCCCCC		23403867
102	Phosphorylation	SKQPPPASSPTKRKG CCCCCCCCCCCCCCC		23927012
103	Phosphorylation	KQPPPASSPTKRKGR CCCCCCCCCCCCCCC		23927012
105	Phosphorylation	PPPASSPTKRKGRSR CCCCCCCCCCCCCCC		23403867
111	Phosphorylation	PTKRKGRSRALEAVP CCCCCCCCCCCCCCC		10392763
123	Phosphorylation	AVPAPPASGPRAPAK CCCCCCCCCCCCCCC		10392771
132	Phosphorylation	PRAPAKESPPKRVPD CCCCCCCCCCCCCCC		28176443
141	Phosphorylation	PKRVPDPSPVTKGTA CCCCCCCCCCCCCCC		29255136
144	Phosphorylation	VPDPSPVTKGTAAES CCCCCCCCCCCCCHH		23403867
147	Phosphorylation	PSPVTKGTAAESGEE CCCCCCCCCCHHHHH		26074081
151	Ubiquitination	TKGTAAESGEEAARA CCCCCCHHHHHHHHH		-
151	Phosphorylation	TKGTAAESGEEAARA CCCCCCHHHHHHHHH		25056879
165	Ubiquitination	AIPRELPVKSSSLLP HCCCCCCCCCHHCCC		-
166	Methylation	IPRELPVKSSSLLPE CCCCCCCCCHHCCCC		-
167	Phosphorylation	PRELPVKSSSLLPEI CCCCCCCCHHCCCCC		27251275
168	Phosphorylation	RELPVKSSSLLPEIK CCCCCCCHHCCCCCC		27251275
169	Phosphorylation	ELPVKSSSLLPEIKP CCCCCCHHCCCCCCC		27251275
215	Ubiquitination	ASDADGLKPRNHFGV CCCCCCCCCCCCCCC		-
246	Phosphorylation	HVELNLKTPKNLDSL EEEEECCCCCCHHHC		27251275
266	Methylation	PFSQPVHKGNTATKI CCCCCCCCCCCCCEE		-
329	Phosphorylation	EKKVMPNSPQNGVLV CCCCCCCCCCCCEEE		25159151
335	Ubiquitination	NSPQNGVLVKETAIE CCCCCCEEEEECEEE		-
346	Phosphorylation	TAIETKVTVSEEEIL CEEEEECEECHHHHC		23927012
348	Phosphorylation	IETKVTVSEEEILPA EEEECEECHHHHCCC		28355574
356	Phosphorylation	EEEILPATRGMNGDS HHHHCCCCCCCCCCC		20068231
389	Phosphorylation	QTDAGCLSEPVASAL CCCCCCCCCCHHHHC		27251275
394	Phosphorylation	CLSEPVASALIPVKD CCCCCHHHHCCCCCC		27251275
410	Phosphorylation	KLLEKEDSEAADSKS CCCCCCCCCHHCCCE		22617229
415	Phosphorylation	EDSEAADSKSLVLEN CCCCHHCCCEEEEEE		26552605
417	Phosphorylation	SEAADSKSLVLENVT CCHHCCCEEEEEECC		28355574
424	Phosphorylation	SLVLENVTDTAQDIP EEEEEECCCCHHHCC		28102081
426	Phosphorylation	VLENVTDTAQDIPTT EEEECCCCHHHCCCC		25841592
430	Ubiquitination	VTDTAQDIPTTVDTK CCCCHHHCCCCCCCC		-
450	Phosphorylation	AMPKPQHTFSDSQSP CCCCCCCCCCCCCCC		25159151
452	Phosphorylation	PKPQHTFSDSQSPAE CCCCCCCCCCCCCCC		30576142
454	Phosphorylation	PQHTFSDSQSPAESS CCCCCCCCCCCCCCC		27251275
456	Phosphorylation	HTFSDSQSPAESSPG CCCCCCCCCCCCCCC		29743597
460	Phosphorylation	DSQSPAESSPGPSLS CCCCCCCCCCCCCCC		30576142
461	Phosphorylation	SQSPAESSPGPSLSL CCCCCCCCCCCCCCC		29743597
465	Phosphorylation	AESSPGPSLSLSAPA CCCCCCCCCCCCCCC		23090842
467	Phosphorylation	SSPGPSLSLSAPAPG CCCCCCCCCCCCCCC		23090842
469	Phosphorylation	PGPSLSLSAPAPGDV CCCCCCCCCCCCCCC		26074081
480	Phosphorylation	PGDVPKDTCVQSPIS CCCCCCCCCCCCCCC		29496963
484	Phosphorylation	PKDTCVQSPISSFPC CCCCCCCCCCCCCCC		28355574
487	Phosphorylation	TCVQSPISSFPCTDL CCCCCCCCCCCCCCC		30108239
488	Phosphorylation	CVQSPISSFPCTDLK CCCCCCCCCCCCCCC		30108239
492	Phosphorylation	PISSFPCTDLKVSEN CCCCCCCCCCCCCCC		26074081
524	Phosphorylation	LLELGGETTPPLSTE EEECCCCCCCCCCCC		29255136
525	Phosphorylation	LELGGETTPPLSTER EECCCCCCCCCCCCC		29255136
528	Ubiquitination	GGETTPPLSTERSPE CCCCCCCCCCCCCHH		-
529	Phosphorylation	GETTPPLSTERSPEA CCCCCCCCCCCCHHH		23401153
530	O-linked_Glycosylation	ETTPPLSTERSPEAV CCCCCCCCCCCHHHC		30379171
530	Phosphorylation	ETTPPLSTERSPEAV CCCCCCCCCCCHHHC		29255136
533	Phosphorylation	PPLSTERSPEAVGSE CCCCCCCCHHHCCCC		29255136
539	Phosphorylation	RSPEAVGSECPSRVL CCHHHCCCCCCCCEE		30278072
543	Phosphorylation	AVGSECPSRVLVQVR HCCCCCCCCEEEEEE		30278072
551	Phosphorylation	RVLVQVRSFVLPVES CEEEEEEEEEEECCC		28857561
558	Phosphorylation	SFVLPVESTQDVSSQ EEEEECCCCCCCHHC		28122231
559	Phosphorylation	FVLPVESTQDVSSQV EEEECCCCCCCHHCC		28857561
563	Phosphorylation	VESTQDVSSQVIPES CCCCCCCHHCCCCCC		28122231
564	Phosphorylation	ESTQDVSSQVIPESS CCCCCCHHCCCCCCC		27251275
617	Phosphorylation	TAELAAKSGPQVIPP HHHHHHHHCCCCCCC		46161003
636	Phosphorylation	TLPIQAQSQGSRTPL CCCEEEECCCCCCCC		113334169
639	O-linked_Glycosylation	IQAQSQGSRTPLMAE EEEECCCCCCCCEEE		30379171
709	Phosphorylation	EIIKQMDSAVCMPMK HHHHHHHHHCCCCCC		46161007
725	Phosphorylation	KKARMPNSPAPHFAM HHCCCCCCCCCCCCC		25159151
747	Acetylation	LEKVFDPKVFTFGLG HHHHCCCCEEEECCC		87879
755	Acetylation	VFTFGLGKKKESQPE EEEECCCCCCCCCCC		25953088
755	Ubiquitination	VFTFGLGKKKESQPE EEEECCCCCCCCCCC		-
759	Phosphorylation	GLGKKKESQPEMSPA CCCCCCCCCCCCCHH		30576142
764	Phosphorylation	KESQPEMSPALHLMQ CCCCCCCCHHHHHHH		25159151
785	Phosphorylation	KLRPKRASAEQSVLF CCCCCCCCHHHHHHH		28555341
789	Phosphorylation	KRASAEQSVLFKSLH CCCCHHHHHHHHHCC		28122231
793	Methylation	AEQSVLFKSLHTNTN HHHHHHHHHCCCCCC		-
827	Phosphorylation	TNGGIKRSRLEKSAL CCCCCCHHHHHHHHH		20068231
832	Phosphorylation	KRSRLEKSALFSSLL CHHHHHHHHHHHHHH		29116813
836	Phosphorylation	LEKSALFSSLLSSLP HHHHHHHHHHHHCCC		14895061
837	Phosphorylation	EKSALFSSLLSSLPQ HHHHHHHHHHHCCCC		29116813
840	Phosphorylation	ALFSSLLSSLPQDKI HHHHHHHHCCCCCCC		29116813
841	O-linked_Glycosylation	LFSSLLSSLPQDKIF HHHHHHHCCCCCCCC		30379171
841	Phosphorylation	LFSSLLSSLPQDKIF HHHHHHHCCCCCCCC		14895073
879	Phosphorylation	QSSVSQPTTEGAPPC CCCCCCCCCCCCCCC		46161037
880	Phosphorylation	SSVSQPTTEGAPPCG CCCCCCCCCCCCCCC		46161043
900	Phosphorylation	SNLLPDNSLKVFNFN HCCCCCCCEEEEECC		113334173
908	Phosphorylation	LKVFNFNSSSTSHSS EEEEECCCCCCCCCC		30576142
909	Phosphorylation	KVFNFNSSSTSHSSL EEEECCCCCCCCCCC		30576142
910	Phosphorylation	VFNFNSSSTSHSSLK EEECCCCCCCCCCCC		28857561
911	Phosphorylation	FNFNSSSTSHSSLKS EECCCCCCCCCCCCC		28857561
912	Phosphorylation	NFNSSSTSHSSLKSP ECCCCCCCCCCCCCH		28857561
914	Phosphorylation	NSSSTSHSSLKSPSH CCCCCCCCCCCCHHH		28857561
915	Phosphorylation	SSSTSHSSLKSPSHM CCCCCCCCCCCHHHH		28857561
917	Methylation	STSHSSLKSPSHMEK CCCCCCCCCHHHHHH		-
918	Phosphorylation	TSHSSLKSPSHMEKY CCCCCCCCHHHHHHC		29496963
920	Phosphorylation	HSSLKSPSHMEKYPQ CCCCCCHHHHHHCCC		50564265
925	Phosphorylation	SPSHMEKYPQKEKTK CHHHHHHCCCCCCCH		50564271
947	Ubiquitination	NLHLPETKFSELSKL CCCCCCCHHHHHHHH		-
953	Ubiquitination	TKFSELSKLKNDDME CHHHHHHHHCCCCHH		-
961	Ubiquitination	LKNDDMEKANHIESV HCCCCHHHHHHHHHH		-
970	Ubiquitination	NHIESVIKSNLPNCA HHHHHHHHCCCCCCC		-
971	Phosphorylation	HIESVIKSNLPNCAN HHHHHHHCCCCCCCC		18669648
979	Phosphorylation	NLPNCANSDTDFMGL CCCCCCCCCCCCHHH		82900435
981	Phosphorylation	PNCANSDTDFMGLFK CCCCCCCCCCHHHHC		28857561
988	Methylation	TDFMGLFKSSRYDPS CCCHHHHCCCCCCCC		-
988	Ubiquitination	TDFMGLFKSSRYDPS CCCHHHHCCCCCCCC		-
989	Phosphorylation	DFMGLFKSSRYDPSI CCHHHHCCCCCCCCC		18669648
992	Phosphorylation	GLFKSSRYDPSISFS HHHCCCCCCCCCEEE		12633639
995	Phosphorylation	KSSRYDPSISFSGMS CCCCCCCCCEEECCC		27080861
997	Phosphorylation	SRYDPSISFSGMSLS CCCCCCCEEECCCCC		22817900
999	Phosphorylation	YDPSISFSGMSLSDT CCCCCEEECCCCCCC		30576142
1002	Phosphorylation	SISFSGMSLSDTMTL CCEEECCCCCCCEEE		27080861
1004	Phosphorylation	SFSGMSLSDTMTLRG EEECCCCCCCEEECH		27080861
1006	Phosphorylation	SGMSLSDTMTLRGSV ECCCCCCCEEECHHH		46161013
1008	Phosphorylation	MSLSDTMTLRGSVQN CCCCCCEEECHHHCC		30576142
1012	Phosphorylation	DTMTLRGSVQNKLNP CCEEECHHHCCCCCC		21406692
1016	Ubiquitination	LRGSVQNKLNPRPGK ECHHHCCCCCCCCCE		-
1023	Ubiquitination	KLNPRPGKVVIYSEP CCCCCCCEEEEECCC		-
1027	Phosphorylation	RPGKVVIYSEPDVSE CCCEEEEECCCCCCH		83571
1028	Phosphorylation	PGKVVIYSEPDVSEK CCEEEEECCCCCCHH		110761057
1033	Phosphorylation	IYSEPDVSEKCIEVF EECCCCCCHHHHHHH		113334161
1104	Phosphorylation	ERHEEAESDKPVVIG HHHHHHHCCCCEEEE		23312004
1112	Phosphorylation	DKPVVIGSIRHVVQD CCCEEEEEHHHHHHH		24719451
1211	Ubiquitination	PLKMGGRKVEFPTDP EECCCCEECCCCCCC		-
1219	Ubiquitination	VEFPTDPKVVVYEKP CCCCCCCCEEEEECC		-
1223	Phosphorylation	TDPKVVVYEKPFFEG CCCCEEEEECCCCCC		28064214
1225	Ubiquitination	PKVVVYEKPFFEGKC CCEEEEECCCCCCEE		-
1332	Ubiquitination	SEKNFGSKGSSIDVL ECCCCCCCCCCCEEE		-
1346	Ubiquitination	LGIVANLKETGYGVK EEEEEEHHHCCCCCE		-
1385	Phosphorylation	ILDKGFYTSFEDWGG EECCCCEEEHHHCCC		27251275
1386	Phosphorylation	LDKGFYTSFEDWGGK ECCCCEEEHHHCCCC		27251275
1393	Acetylation	SFEDWGGKNCKISSV EHHHCCCCCCEECCC		19807577
1393	Ubiquitination	SFEDWGGKNCKISSV EHHHCCCCCCEECCC		-
1396	Acetylation	DWGGKNCKISSVQPI HCCCCCCEECCCCCE		25953088
1396	Ubiquitination	DWGGKNCKISSVQPI HCCCCCCEECCCCCE		-
1409	Phosphorylation	PICLDSFTGPRRRNQ CEEECCCCCCCCCCE		24719451
1429	Phosphorylation	EPQFQGHSQSFEETT CCCCCCCCCCHHHHH		28348404
1431	Phosphorylation	QFQGHSQSFEETTSQ CCCCCCCCHHHHHHH		28348404
1435	Phosphorylation	HSQSFEETTSQIDDS CCCCHHHHHHHCCCC		28348404
1436	Phosphorylation	SQSFEETTSQIDDSF CCCHHHHHHHCCCCC		28348404
1437	Phosphorylation	QSFEETTSQIDDSFS CCHHHHHHHCCCCCC		28348404
1491	Phosphorylation	PPGATFKSLRFIDVE CCCCEEEEEEEEEEE		24719451
1516	Ubiquitination	REDFKGKKIELNAET CCCCCCCEEEECCEE		-
1569	Phosphorylation	PAEVPNWYEFSGCRQ CCCCCCCEECCCCCC		83575
1579	Phosphorylation	SGCRQIGSLRPFVQK CCCCCCCCCHHHHHH		24719451
1586	Acetylation	SLRPFVQKRIYFRLR CCHHHHHHHHEEEEC		11688661
1611	Ubiquitination	NGNLEDLKLLRIQVM CCCHHHHEEEEEEEE		-
1674	Ubiquitination	DSQFWSLKSDGRIYS CCCCEEECCCCCEEC		-
1682	Ubiquitination	SDGRIYSKLKPNLVL CCCCEECCCCCCEEE		-
1684	Ubiquitination	GRIYSKLKPNLVLDI CCEECCCCCCEEEEE		-
1709	Ubiquitination	IILNTVSKEKFTQVW EEEEECCHHHHHHHE		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRBG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRBG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRBG1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CRBG1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.