TAF4_HUMAN - dbPTM
TAF4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF4_HUMAN
UniProt AC O00268
Protein Name Transcription initiation factor TFIID subunit 4
Gene Name TAF4
Organism Homo sapiens (Human).
Sequence Length 1085
Subcellular Localization Nucleus.
Protein Description Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone..
Protein Sequence MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPPVLSLTQPTQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQIQLNPLQPVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDCPGPGSGAEGSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKAFLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAAGSDLLDEVF
---CCCCCHHHHHHH		21.9929759185
15PhosphorylationLDEVFFNSEVDEKVV
HHHHHCCCCCCHHHH		33.5629759185
23PhosphorylationEVDEKVVSDLVGSLE
CCCHHHHHHHHHCHH		28.37-
36PhosphorylationLESQLAASAAHHHHL
HHHHHHHHHHHHHCC		22.0027251275
47PhosphorylationHHHLAPRTPEVRAAA
HHCCCCCCHHHHHHH		23.8128796482
66PhosphorylationGNHVVSGSPAGAAGA
CCCCCCCCCCCCCCC		12.2228555341
109PhosphorylationPQRPGPPSPRRPLVP
CCCCCCCCCCCCCCC		33.8828985074
396PhosphorylationVPPPAPGTPTGLPKG
CCCCCCCCCCCCCCC		19.3328348404
409PhosphorylationKGAAGAVTQSLSRTP
CCHHHHHHHHHCCCC		16.35-
409O-linked_GlycosylationKGAAGAVTQSLSRTP
CCHHHHHHHHHCCCC		16.3520068230
411PhosphorylationAAGAVTQSLSRTPTA
HHHHHHHHHCCCCCC		20.9528555341
413O-linked_GlycosylationGAVTQSLSRTPTATT
HHHHHHHCCCCCCCC		39.0820068230
414MethylationAVTQSLSRTPTATTS
HHHHHHCCCCCCCCC		50.4481471823
415PhosphorylationVTQSLSRTPTATTSG
HHHHHCCCCCCCCCC		22.9328674419
421PhosphorylationRTPTATTSGIRATLT
CCCCCCCCCCCCEEC		28.06-
424MethylationTATTSGIRATLTPTV
CCCCCCCCCEECCCE		25.6624129315
424Asymmetric dimethylarginineTATTSGIRATLTPTV
CCCCCCCCCEECCCE		25.66-
435MethylationTPTVLAPRLPQPPQN
CCCEECCCCCCCCCC		54.0924129315
435Asymmetric dimethylarginineTPTVLAPRLPQPPQN
CCCEECCCCCCCCCC		54.09-
491MethylationPQTTMAPRPATPTSA
CCCCCCCCCCCCCCC		24.7730763275
491DimethylationPQTTMAPRPATPTSA
CCCCCCCCCCCCCCC		24.77-
516MethylationPGTPIIARQVTPTTI
CCCCEEEEECCCHHH		22.5430763281
516DimethylationPGTPIIARQVTPTTI
CCCCEEEEECCCHHH		22.54-
528O-linked_GlycosylationTTIIKQVSQAQTTVQ
HHHHHHHHHCCCCCC		19.8020068230
528PhosphorylationTTIIKQVSQAQTTVQ
HHHHHHHHHCCCCCC		19.80-
528O-linked_GlycosylationTTIIKQVSQAQTTVQ
HHHHHHHHHCCCCCC		19.8030059200
532O-linked_GlycosylationKQVSQAQTTVQPSAT
HHHHHCCCCCCCCCC		31.7620068230
533O-linked_GlycosylationQVSQAQTTVQPSATL
HHHHCCCCCCCCCCH		12.6920068230
537O-linked_GlycosylationAQTTVQPSATLQRSP
CCCCCCCCCCHHCCC		19.4520068230
539O-linked_GlycosylationTTVQPSATLQRSPGV
CCCCCCCCHHCCCCC		27.9720068230
543PhosphorylationPSATLQRSPGVQPQL
CCCCHHCCCCCCCEE		17.0330266825
558PhosphorylationVLGGAAQTASLGTAT
EECCHHCCCCCCCEE		17.3128450419
560PhosphorylationGGAAQTASLGTATAV
CCHHCCCCCCCEEEE		30.6228450419
563PhosphorylationAQTASLGTATAVQTG
HCCCCCCCEEEEECC		26.5727080861
565PhosphorylationTASLGTATAVQTGTP
CCCCCCEEEEECCCC		27.4827080861
571PhosphorylationATAVQTGTPQRTVPG
EEEEECCCCCCCCCC		21.4526055452
582PhosphorylationTVPGATTTSSAATET
CCCCCCCCCCHHHHH		19.1424667141
583PhosphorylationVPGATTTSSAATETM
CCCCCCCCCHHHHHH		18.8524667141
601PhosphorylationKKCKNFLSTLIKLAS
HHHHHHHHHHHHHHH		19.6122210691
602PhosphorylationKCKNFLSTLIKLASS
HHHHHHHHHHHHHHC		34.3522210691
608PhosphorylationSTLIKLASSGKQSTE
HHHHHHHHCCCCCHH		50.4918785766
611UbiquitinationIKLASSGKQSTETAA
HHHHHCCCCCHHHHH		42.9229967540
621UbiquitinationTETAANVKELVQNLL
HHHHHHHHHHHHHHH		45.1729967540
631UbiquitinationVQNLLDGKIEAEDFT
HHHHHCCCCCHHHHH		36.7229967540
647PhosphorylationRLYRELNSSPQPYLV
HHHHHHHCCCCCCHH		56.8927050516
648PhosphorylationLYRELNSSPQPYLVP
HHHHHHCCCCCCHHH		26.8727050516
652PhosphorylationLNSSPQPYLVPFLKR
HHCCCCCCHHHHHHH		18.3221712546
660PhosphorylationLVPFLKRSLPALRQL
HHHHHHHHHHHHHHH		36.8026307563
712O-linked_GlycosylationTAGKTAATVTSALQP
HCCCCHHHHHHHHCC		23.1220068230
714O-linked_GlycosylationGKTAATVTSALQPPV
CCCHHHHHHHHCCCE		12.1520068230
723O-linked_GlycosylationALQPPVLSLTQPTQV
HHCCCEEECCCCCEE		29.6020068230
728O-linked_GlycosylationVLSLTQPTQVGVGKQ
EEECCCCCEECCCCC		26.5220068230
754DimethylationPKPGALIRPPQVTLT
CCCCCCCCCCEEEEE		37.38-
754MethylationPKPGALIRPPQVTLT
CCCCCCCCCCEEEEE		37.3854561839
769MethylationQTPMVALRQPHNRIM
CCCCEEECCCCCCEE		37.9454561845
769DimethylationQTPMVALRQPHNRIM
CCCCEEECCCCCCEE		37.94-
795AcetylationLQPVPVVKPAVLPGT
CCCCCCCCCCCCCCC		27.7423954790
802PhosphorylationKPAVLPGTKALSAVS
CCCCCCCCHHHHHHH		15.9422210691
817AcetylationAQAAAAQKNKLKEPG
HHHHHHHHCCCCCCC		51.8525953088
827PhosphorylationLKEPGGGSFRDDDDI
CCCCCCCCCCCCCCH		22.0022115753
855PhosphorylationESARILATNSELVGT
HHHHHHHCCHHHHHH		35.5120068231
857PhosphorylationARILATNSELVGTLT
HHHHHCCHHHHHHHH		28.1420068231
862PhosphorylationTNSELVGTLTRSCKD
CCHHHHHHHHHHCCC		19.9220068231
864PhosphorylationSELVGTLTRSCKDET
HHHHHHHHHHCCCCE		22.0020068231
866PhosphorylationLVGTLTRSCKDETFL
HHHHHHHHCCCCEEE		21.9329083192
929AcetylationQQKNFSYKDDDRYEQ
HHHCCCCCCCCHHHH		54.1826051181
934PhosphorylationSYKDDDRYEQASDVR
CCCCCCHHHHHHHHH		21.2727642862
945UbiquitinationSDVRAQLKFFEQLDQ
HHHHHHHHHHHHHHH		35.6129967540
987UbiquitinationEQLRLKQKAKEMQQQ
HHHHHHHHHHHHHHH		60.8924816145
1027PhosphorylationVDCPGPGSGAEGSGP
CCCCCCCCCCCCCCC		37.6524732914
1032PhosphorylationPGSGAEGSGPGSVVP
CCCCCCCCCCCCCCC		33.0624732914
1036PhosphorylationAEGSGPGSVVPGSSG
CCCCCCCCCCCCCCC		24.0724732914
1041PhosphorylationPGSVVPGSSGVGTPR
CCCCCCCCCCCCCCC		20.1824732914
1042PhosphorylationGSVVPGSSGVGTPRQ
CCCCCCCCCCCCCCC		43.3324732914
1046PhosphorylationPGSSGVGTPRQFTRQ
CCCCCCCCCCCHHHH		16.9421815630
1056PhosphorylationQFTRQRITRVNLRDL
CHHHHHCEEEEHHHH		30.65-
1073PhosphorylationCLENERETSHSLLLY
HHCCCCHHHHHHHHH		37.6524719451
1076PhosphorylationNERETSHSLLLYKAF
CCCHHHHHHHHHHHH		22.0824719451
1080PhosphorylationTSHSLLLYKAFLK--
HHHHHHHHHHHHC--		10.5524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBX5_HUMANCBX5physical
11959914
TAF4_HUMANTAF4physical
11564872
TAF12_HUMANTAF12physical
11564872
TAF8_HUMANTAF8physical
11564872
TAF5_HUMANTAF5physical
11406595
KAT2A_HUMANKAT2Aphysical
11406595
SUPT3_HUMANSUPT3Hphysical
11406595
TAF10_HUMANTAF10physical
11406595
TAF12_HUMANTAF12physical
12237304
CREB1_HUMANCREB1physical
15703171
TAF12_HUMANTAF12physical
15601843
TAF6_HUMANTAF6physical
22939629
TBP_HUMANTBPphysical
22939629
TAF7_HUMANTAF7physical
22939629
TAF9_HUMANTAF9physical
22939629
TRRAP_HUMANTRRAPphysical
22939629
TAF9B_HUMANTAF9Bphysical
22939629
SP1_HUMANSP1physical
11988536
APC1_HUMANANAPC1physical
26344197
APC7_HUMANANAPC7physical
26344197
CDC16_HUMANCDC16physical
26344197
NP1L4_HUMANNAP1L4physical
26344197
TAF1_HUMANTAF1physical
26344197
TAF10_HUMANTAF10physical
26344197
TAF5_HUMANTAF5physical
26344197
TAF6_HUMANTAF6physical
26344197
TAF7_HUMANTAF7physical
26344197
SF3B3_HUMANSF3B3physical
11406595
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF4_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory