| UniProt ID | TAF5_HUMAN | |
|---|---|---|
| UniProt AC | Q15542 | |
| Protein Name | Transcription initiation factor TFIID subunit 5 | |
| Gene Name | TAF5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 800 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.. | |
| Protein Sequence | MAALAEEQTEVAVKLEPEGPPTLLPPQAGDGAGEGSGGTTNNGPNGGGGNVAASSSTGGDGGTPKPTVAVSAAAPAGAAPVPAAAPDAGAPHDRQTLLAVLQFLRQSKLREAEEALRREAGLLEEAVAGSGAPGEVDSAGAEVTSALLSRVTASAPGPAAPDPPGTGASGATVVSGSASGPAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAYSPQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Sumoylation | EQTEVAVKLEPEGPP CCEEEEEEECCCCCC | 37.08 | - | |
| 14 | Sumoylation | EQTEVAVKLEPEGPP CCEEEEEEECCCCCC | 37.08 | - | |
| 287 | Ubiquitination | RVLSSLTKKEHMKGN HHHHHHCHHHHHCCC | 62.55 | 29967540 | |
| 318 | Acetylation | RDSYQLLKRHLQEKQ HHHHHHHHHHHHHHH | 46.49 | 26051181 | |
| 318 | Ubiquitination | RDSYQLLKRHLQEKQ HHHHHHHHHHHHHHH | 46.49 | - | |
| 358 | Phosphorylation | QIDAMVGSLAGEAKR HHHHHHHHHHHHHHH | 12.02 | - | |
| 399 | Acetylation | EGENEEGKPKKKKPK CCCCCCCCCCCCCCC | 57.87 | 26051181 | |
| 435 | O-linked_Glycosylation | PLPELKDSDKLDKIM CCCCCCCHHHHHHHH | 34.75 | 29351928 | |
| 498 | Phosphorylation | DSTVRVWSVTPKKLR CCEEEEEEECHHHHH | 17.16 | 24719451 | |
| 500 | Phosphorylation | TVRVWSVTPKKLRSV EEEEEEECHHHHHCC | 24.71 | 24719451 | |
| 508 | Ubiquitination | PKKLRSVKQASDLSL HHHHHCCCCHHCCCC | 41.20 | 29967540 | |
| 511 | Phosphorylation | LRSVKQASDLSLIDK HHCCCCHHCCCCCCC | 36.27 | 21406692 | |
| 514 | Phosphorylation | VKQASDLSLIDKESD CCCHHCCCCCCCCCH | 28.41 | 21815630 | |
| 518 | Ubiquitination | SDLSLIDKESDDVLE HCCCCCCCCCHHHHH | 52.72 | 29967540 | |
| 520 | Phosphorylation | LSLIDKESDDVLERI CCCCCCCCHHHHHHH | 44.87 | 24719451 | |
| 531 | Ubiquitination | LERIMDEKTASELKI HHHHHCCCCHHHHHH | 45.16 | 32015554 | |
| 711 | Phosphorylation | VGELKGHTDTVCSLR EEECCCCCCCEEEEE | 41.87 | 22210691 | |
| 713 | Phosphorylation | ELKGHTDTVCSLRFS ECCCCCCCEEEEEEC | 25.27 | - | |
| 716 | Phosphorylation | GHTDTVCSLRFSRDG CCCCCEEEEEECCCC | 20.45 | - | |
| 797 | Phosphorylation | LVLAAGAYSPQ---- EEEEEECCCCC---- | 21.70 | 20068231 | |
| 798 | Phosphorylation | VLAAGAYSPQ----- EEEEECCCCC----- | 19.11 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TAF5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAF5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAF5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TAF1_HUMAN | TAF1 | physical | 9045704 | |
| TAF6_HUMAN | TAF6 | physical | 9045704 | |
| TAF7_HUMAN | TAF7 | physical | 9045704 | |
| TBP_HUMAN | TBP | physical | 9045704 | |
| TAF9_HUMAN | TAF9 | physical | 9045704 | |
| TAF11_HUMAN | TAF11 | physical | 9045704 | |
| TAF12_HUMAN | TAF12 | physical | 9045704 | |
| CPSF1_HUMAN | CPSF1 | physical | 9311784 | |
| TAF6_HUMAN | TAF6 | physical | 22939629 | |
| TAF7_HUMAN | TAF7 | physical | 22939629 | |
| TAF9_HUMAN | TAF9 | physical | 22939629 | |
| APC10_HUMAN | ANAPC10 | physical | 26344197 | |
| CDC16_HUMAN | CDC16 | physical | 26344197 | |
| TAF2_HUMAN | TAF2 | physical | 26344197 | |
| TAF6_HUMAN | TAF6 | physical | 26344197 | |
| TBP_HUMAN | TBP | physical | 26344197 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
