dbPTM

GILT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GILT_HUMAN
UniProt AC	P13284
Protein Name	Gamma-interferon-inducible lysosomal thiol reductase
Gene Name	IFI30
Organism	Homo sapiens (Human).
Sequence Length	250
Subcellular Localization	Secreted . Lysosome .
Protein Description	Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity)..
Protein Sequence	MTLSPLLLFLPPLLLLLDVPTAAVQASPLQALDFFGNGPPVNYKTGNLYLRGPLKKSNAPLVNVTLYYEALCGGCRAFLIRELFPTWLLVMEILNVTLVPYGNAQEQNVSGRWEFKCQHGEEECKFNKVEACVLDELDMELAFLTIVCMEEFEDMERSLPLCLQLYAPGLSPDTIMECAMGDRGMQLMHANAQRTDALQPPHEYVPWVTVNGKPLEDQTQLLTLVCQLYQGKKPDVCPSSTSSLRSVCFK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	GPPVNYKTGNLYLRG CCCCCCCCCCEEEEC	22.42	18187866
63	N-linked_Glycosylation	KSNAPLVNVTLYYEA CCCCCCEEEEHHHHH	28.83	UniProtKB CARBOHYD
95	N-linked_Glycosylation	LLVMEILNVTLVPYG HHHHHHHCCEEEECC	30.32	UniProtKB CARBOHYD
108	N-linked_Glycosylation	YGNAQEQNVSGRWEF CCCCCCCCCCCCEEE	29.21	UniProtKB CARBOHYD
116	Acetylation	VSGRWEFKCQHGEEE CCCCEEEEECCCCCC	22.82	27178108

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GILT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GILT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GILT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
ZO1_HUMAN	TJP1	physical	26186194
F120A_HUMAN	FAM120A	physical	26186194
L2GL2_HUMAN	LLGL2	physical	26186194
DAPK1_HUMAN	DAPK1	physical	26186194
TTC31_HUMAN	TTC31	physical	26186194
MKLN1_HUMAN	MKLN1	physical	26186194
ELP3_HUMAN	ELP3	physical	26186194
DEP1B_HUMAN	DEPDC1B	physical	26186194
UBE3B_HUMAN	UBE3B	physical	26186194
RT07_HUMAN	MRPS7	physical	26186194
ZO2_HUMAN	TJP2	physical	26186194
EOGT_HUMAN	EOGT	physical	26186194
TIMP3_HUMAN	TIMP3	physical	26186194
PRC1_HUMAN	PRC1	physical	26186194
TRI68_HUMAN	TRIM68	physical	26186194
B9D1_HUMAN	B9D1	physical	26186194
PDIA5_HUMAN	PDIA5	physical	26186194
FBLN1_HUMAN	FBLN1	physical	26186194
EGFL7_HUMAN	EGFL7	physical	26186194
GTPB2_HUMAN	GTPBP2	physical	26186194
F122B_HUMAN	FAM122B	physical	26186194
BRCA1_HUMAN	BRCA1	physical	26186194
SLX4I_HUMAN	SLX4IP	physical	26186194
B4GT1_HUMAN	B4GALT1	physical	26186194
UBP46_HUMAN	USP46	physical	26186194
G3BP1_HUMAN	G3BP1	physical	26344197
G3BP2_HUMAN	G3BP2	physical	26344197
SNX12_HUMAN	SNX12	physical	26344197
DAPK1_HUMAN	DAPK1	physical	28514442
TTC31_HUMAN	TTC31	physical	28514442
DEP1B_HUMAN	DEPDC1B	physical	28514442
UBE3B_HUMAN	UBE3B	physical	28514442
ZO1_HUMAN	TJP1	physical	28514442
GTPB2_HUMAN	GTPBP2	physical	28514442
ZO2_HUMAN	TJP2	physical	28514442
BRCA1_HUMAN	BRCA1	physical	28514442
F122B_HUMAN	FAM122B	physical	28514442
F120A_HUMAN	FAM120A	physical	28514442
L2GL2_HUMAN	LLGL2	physical	28514442
PRC1_HUMAN	PRC1	physical	28514442
SLX4I_HUMAN	SLX4IP	physical	28514442
EOGT_HUMAN	EOGT	physical	28514442
TRI68_HUMAN	TRIM68	physical	28514442
UBP46_HUMAN	USP46	physical	28514442
TIMP3_HUMAN	TIMP3	physical	28514442
RT07_HUMAN	MRPS7	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GILT_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-45, AND MASSSPECTROMETRY.	18187866 [Abstract]