dbPTM

L2GL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	L2GL2_HUMAN
UniProt AC	Q6P1M3
Protein Name	Lethal(2) giant larvae protein homolog 2
Gene Name	LLGL2
Organism	Homo sapiens (Human).
Sequence Length	1020
Subcellular Localization	Cytoplasm . Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epith
Protein Description	Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity..
Protein Sequence	MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQIHLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLENIWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVPYGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYALVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSHHVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTPAPPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVFLTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQKIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVKCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSRKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTIYAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILVLDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDYGEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDSAETKNHRPGNGAGPKKAPSRARNSGTQSDGEEKQPGLVMERALLSDERVLKEIQSTLEGDRGSGNWRSHRAAVGCSLSNGGAE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	RDLFQFNKTVEHGFP HHHHHHCCCCCCCCC	56.06	-
26	Phosphorylation	DLFQFNKTVEHGFPH HHHHHCCCCCCCCCC	32.03	-
36	Phosphorylation	HGFPHQPSALGYSPS CCCCCCCCCCCCCCC	29.56	-
40	Phosphorylation	HQPSALGYSPSLRIL CCCCCCCCCCCEEEE	20.47	-
105	Ubiquitination	HLWSLKVKGGASELQ EEEEEEEECCCCCCC	50.46	21906983
105 (in isoform 3)	Ubiquitination	-	50.46	21906983
105 (in isoform 2)	Ubiquitination	-	50.46	21890473
105 (in isoform 1)	Ubiquitination	-	50.46	21890473
118	Phosphorylation	LQEDESFTLRGPPGA CCCCCCEEECCCCCC	25.48	24719451
253	Phosphorylation	VSCHSDGSYCQWPVS EEEECCCCCCCCCCC	27.94	-
275	Phosphorylation	PLRSLVPYGPFPCKA CHHHCCCCCCCCHHH	29.92	28509920
281	Ubiquitination	PYGPFPCKAITRILW CCCCCCHHHHHHHHH	42.96	-
284	Phosphorylation	PFPCKAITRILWLTT CCCHHHHHHHHHEEC	19.27	28509920
453	Phosphorylation	TVRFWDASGVCLRLL CEEEEEHHHHHHHHH	29.32	27251275
471	Phosphorylation	STVRVFLTDTDPNEN CEEEEEECCCCCCCC	25.95	23663014
473	Phosphorylation	VRVFLTDTDPNENFS EEEEECCCCCCCCCC	48.39	23663014
480	Phosphorylation	TDPNENFSAQGEDEW CCCCCCCCCCCCCCC	31.12	28355574
492	Ubiquitination	DEWPPLRKVGSFDPY CCCCCCCCCCCCCCC	59.64	-
495	Phosphorylation	PPLRKVGSFDPYSDD CCCCCCCCCCCCCCC	29.48	28857561
499	Phosphorylation	KVGSFDPYSDDPRLG CCCCCCCCCCCCCCC	26.95	27273156
500	Phosphorylation	VGSFDPYSDDPRLGI CCCCCCCCCCCCCCC	40.71	28152594
625 (in isoform 1)	Ubiquitination	-	15.27	21890473
625 (in isoform 2)	Ubiquitination	-	15.27	21890473
625	Ubiquitination	QRRQVFVKCTLHPSD HHCEEEEEEEECHHH	15.27	21890473
625	Methylation	QRRQVFVKCTLHPSD HHCEEEEEEEECHHH	15.27	44493853
627	Phosphorylation	RQVFVKCTLHPSDQL CEEEEEEEECHHHHH	23.53	22210691
645	Phosphorylation	GPLSRVKSLKKSLRQ CCHHHHHHHHHHHHH	42.43	24719451
647	Methylation	LSRVKSLKKSLRQSF HHHHHHHHHHHHHHH	47.62	-
649	Phosphorylation	RVKSLKKSLRQSFRR HHHHHHHHHHHHHHH	27.48	22167270
653	Phosphorylation	LKKSLRQSFRRMRRS HHHHHHHHHHHHHHH	17.81	30266825
660	Phosphorylation	SFRRMRRSRVSSRKR HHHHHHHHHHHHCCC	27.03	24719451
663	Phosphorylation	RMRRSRVSSRKRHPA HHHHHHHHHCCCCCC	24.26	24719451
666 (in isoform 2)	Ubiquitination	-	57.94	-
666	Ubiquitination	RSRVSSRKRHPAGPP HHHHHHCCCCCCCCC	57.94	-
680	Phosphorylation	PGEAQEGSAKAERPG CCCCCCCCCCCCCCC	26.33	25159151
682	Ubiquitination	EAQEGSAKAERPGLQ CCCCCCCCCCCCCCC	53.10	-
704	Phosphorylation	QRKIEARSAEDSFTG HHHHHHHHHCHHHHH	42.95	25849741
708	Phosphorylation	EARSAEDSFTGFVRT HHHHHCHHHHHHHHH	19.06	28857561
724 (in isoform 2)	Ubiquitination	-	45.19	21890473
724 (in isoform 1)	Ubiquitination	-	45.19	21890473
724	Ubiquitination	YFADTYLKDSSRHCP HCCCCCCCCCCCCCC	45.19	21890473
726	Phosphorylation	ADTYLKDSSRHCPSL CCCCCCCCCCCCCEE	27.90	24719451
732	Phosphorylation	DSSRHCPSLWAGTNG CCCCCCCEEEEECCC	41.77	24719451
737	Phosphorylation	CPSLWAGTNGGTIYA CCEEEEECCCCEEEE	23.96	21712546
741	Phosphorylation	WAGTNGGTIYAFSLR EEECCCCEEEEEEEE	16.53	21712546
802	Phosphorylation	VAHDLSKSPDMQGSH HHCCCCCCCCCCCCC	23.82	25159151
823	Phosphorylation	EEQFKVFTLPKVSAK HHHEEEEECCCCCCE	45.17	24719451
826	Ubiquitination	FKVFTLPKVSAKLKL EEEEECCCCCCEEEE	52.51	-
847	Phosphorylation	GSRVRRVSVAHFGSR CCEEEEEEEEECCCC	16.27	25849741
853	Phosphorylation	VSVAHFGSRRAEDYG EEEEECCCCCHHHCC	20.04	28348404
916	Phosphorylation	GFYLISPSEFERFSL EEEEECHHHHCCCEE	48.39	-
926 (in isoform 2)	Ubiquitination	-	34.84	-
961	Phosphorylation	APSRARNSGTQSDGE CCCCCCCCCCCCCCC	37.35	30266825
963	Phosphorylation	SRARNSGTQSDGEEK CCCCCCCCCCCCCCC	25.40	30266825
965	Phosphorylation	ARNSGTQSDGEEKQP CCCCCCCCCCCCCCC	47.63	23401153
965 (in isoform 2)	Phosphorylation	-	47.63	-
970	Ubiquitination	TQSDGEEKQPGLVME CCCCCCCCCCCHHHH	58.45	2190698
970 (in isoform 1)	Ubiquitination	-	58.45	21890473
970 (in isoform 2)	Ubiquitination	-	58.45	21890473
982	Phosphorylation	VMERALLSDERVLKE HHHHHHHCCHHHHHH	37.97	24719451
988	Ubiquitination	LSDERVLKEIQSTLE HCCHHHHHHHHHHHC	50.33	-
992	Phosphorylation	RVLKEIQSTLEGDRG HHHHHHHHHHCCCCC	40.39	29978859
993	Phosphorylation	VLKEIQSTLEGDRGS HHHHHHHHHCCCCCC	16.68	29978859
1000	Phosphorylation	TLEGDRGSGNWRSHR HHCCCCCCCCCCCCC	29.82	25159151
1013	Phosphorylation	HRAAVGCSLSNGGAE CCEECCCCCCCCCCC	28.98	25159151
1015	Phosphorylation	AAVGCSLSNGGAE-- EECCCCCCCCCCC--	19.69	30278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
653	S	Phosphorylation	Kinase	PRKCI	Q62074	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
653	S	Phosphorylation		12725730
Phosphorylated at Ser-653 by PRKCI.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of L2GL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAR6A_HUMAN	PARD6A	physical	20360068
KPCI_HUMAN	PRKCI	physical	20360068
PAR6B_HUMAN	PARD6B	physical	20360068
L2GL2_HUMAN	LLGL2	physical	20360068
BAG5_HUMAN	BAG5	physical	24366813
CHIP_HUMAN	STUB1	physical	24366813
DNJA1_HUMAN	DNAJA1	physical	24366813
DNJA2_HUMAN	DNAJA2	physical	24366813
DNJB1_HUMAN	DNAJB1	physical	24366813
KBTB7_HUMAN	KBTBD7	physical	24366813
KPCI_HUMAN	PRKCI	physical	24366813
KPCZ_HUMAN	PRKCZ	physical	24366813
L2GL2_HUMAN	LLGL2	physical	24366813
NUDC_HUMAN	NUDC	physical	24366813
PAR6B_HUMAN	PARD6B	physical	24366813
PAR6G_HUMAN	PARD6G	physical	24366813
RAD18_HUMAN	RAD18	physical	24366813
SQSTM_HUMAN	SQSTM1	physical	24366813
SGT1_HUMAN	SUGT1	physical	24366813
TIM13_HUMAN	TIMM13	physical	24366813
PAR6A_HUMAN	PARD6A	physical	26344197
CCNB1_HUMAN	CCNB1	physical	26496610
LYST_HUMAN	LYST	physical	26496610
ATF2_HUMAN	ATF2	physical	26496610
BPTF_HUMAN	BPTF	physical	26496610
MTOR_HUMAN	MTOR	physical	26496610
M3K1_HUMAN	MAP3K1	physical	26496610
KPCI_HUMAN	PRKCI	physical	26496610
P5CS_HUMAN	ALDH18A1	physical	26496610
RBBP6_HUMAN	RBBP6	physical	26496610
ST5_HUMAN	ST5	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TAF9_HUMAN	TAF9	physical	26496610
SF01_HUMAN	SF1	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
MKNK1_HUMAN	MKNK1	physical	26496610
EXO1_HUMAN	EXO1	physical	26496610
NOLC1_HUMAN	NOLC1	physical	26496610
ZNHI3_HUMAN	ZNHIT3	physical	26496610
DCAF1_HUMAN	VPRBP	physical	26496610
HMGX4_HUMAN	HMGXB4	physical	26496610
DNM1L_HUMAN	DNM1L	physical	26496610
ABCA7_HUMAN	ABCA7	physical	26496610
CASC3_HUMAN	CASC3	physical	26496610
PALLD_HUMAN	PALLD	physical	26496610
ZC3H3_HUMAN	ZC3H3	physical	26496610
K0556_HUMAN	KIAA0556	physical	26496610
DAPK2_HUMAN	DAPK2	physical	26496610
ATP5S_HUMAN	ATP5S	physical	26496610
PAR6A_HUMAN	PARD6A	physical	26496610
ECSIT_HUMAN	ECSIT	physical	26496610
PF21A_HUMAN	PHF21A	physical	26496610
E41LB_HUMAN	EPB41L4B	physical	26496610
CK057_HUMAN	C11orf57	physical	26496610
IMP3_HUMAN	IMP3	physical	26496610
IMPCT_HUMAN	IMPACT	physical	26496610
IWS1_HUMAN	IWS1	physical	26496610
BRE1A_HUMAN	RNF20	physical	26496610
BIRC6_HUMAN	BIRC6	physical	26496610
PKHG1_HUMAN	PLEKHG1	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610
PHAR4_HUMAN	PHACTR4	physical	26496610
BHE41_HUMAN	BHLHE41	physical	26496610
GCC1_HUMAN	GCC1	physical	26496610
ZN668_HUMAN	ZNF668	physical	26496610
LNP_HUMAN	KIAA1715	physical	26496610
FIP1_HUMAN	FIP1L1	physical	26496610
C99L2_HUMAN	CD99L2	physical	26496610
PAR6B_HUMAN	PARD6B	physical	26496610
ZN707_HUMAN	ZNF707	physical	26496610
FMN1_HUMAN	FMN1	physical	26496610
RAD18_HUMAN	RAD18	physical	28514442
PAR6G_HUMAN	PARD6G	physical	28514442
BRWD3_HUMAN	BRWD3	physical	28514442
PKCB1_HUMAN	ZMYND8	physical	28514442
GSE1_HUMAN	GSE1	physical	28514442
KPCI_HUMAN	PRKCI	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
ZN592_HUMAN	ZNF592	physical	28514442
TOPRS_HUMAN	TOPORS	physical	28514442
CATIN_HUMAN	CACTIN	physical	28514442
ZN687_HUMAN	ZNF687	physical	28514442
LIPA1_HUMAN	PPFIA1	physical	28514442
DDA1_HUMAN	DDA1	physical	28514442
TRI26_HUMAN	TRIM26	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
HM20A_HUMAN	HMG20A	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
NKTR_HUMAN	NKTR	physical	28514442
HM20B_HUMAN	HMG20B	physical	28514442
NKAP_HUMAN	NKAP	physical	28514442
RCOR3_HUMAN	RCOR3	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442
KBTB6_HUMAN	KBTBD6	physical	28514442
UBE2A_HUMAN	UBE2A	physical	28514442
NEK7_HUMAN	NEK7	physical	28514442
RCOR1_HUMAN	RCOR1	physical	28514442
NOG1_HUMAN	GTPBP4	physical	28514442
TR150_HUMAN	THRAP3	physical	28514442
DIEXF_HUMAN	DIEXF	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of L2GL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1015, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Mammalian Lgl forms a protein complex with PAR-6 and aPKCindependently of PAR-3 to regulate epithelial cell polarity."; Yamanaka T., Horikoshi Y., Sugiyama Y., Ishiyama C., Suzuki A.,Hirose T., Iwamatsu A., Shinohara A., Ohno S.; Curr. Biol. 13:734-743(2003). Cited for: INTERACTION WITH PARD6B/PAR-6 AND PRKCI/APKC, PHOSPHORYLATION ATSER-653, AND MUTAGENESIS OF SER-641; SER-645; SER-649; SER-653;SER-660 AND SER-663.	12725730 [Abstract]

show