PAR6G_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR6G_HUMAN
• UniProt AC: Q9BYG4
• Protein Name: Partitioning defective 6 homolog gamma
• Gene Name: PARD6G
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Cytoplasm. Cell membrane. Cell junction, tight junction.
• Protein Description: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity)..
• Protein Sequence: MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFEDFYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQRLQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNRSFHKSQTL ----CCCCCCCCCEE	27.05	30266825
8	Phosphorylation	MNRSFHKSQTLRFYD CCCCCCCCCEEEEEE	21.59	30266825
10	Phosphorylation	RSFHKSQTLRFYDCS CCCCCCCEEEEEECC	27.30	27080861
14	Phosphorylation	KSQTLRFYDCSAVEV CCCEEEEEECCEEEE	15.03	27642862
33	Phosphorylation	GAEFRRFSLDRHKPG CCEECCCCCCCCCCC	27.78	24719451
105	Phosphorylation	REEAERGSLGAGSLC HHHHHCCCCCHHHHH	29.83	27251275
110	Phosphorylation	RGSLGAGSLCRRRRA CCCCCHHHHHHHHHH	24.62	30266825
144	Phosphorylation	PRDFRPVSSIIDVDL CCCCCCCCCEEEEEC	20.64	28122231
145	Phosphorylation	RDFRPVSSIIDVDLV CCCCCCCCEEEEECC	24.65	28122231
189	Ubiquitination	VTPHGLEKVPGIFIS ECCCCCCCCCCEEEE	59.79	23000965
295	Phosphorylation	FHPDEAESDEDNDVV CCCCCCCCCCCCCEE	54.04	23898821
306	Phosphorylation	NDVVIEGTLEPARPP CCEEEEEEECCCCCC	18.37	23090842
315	Phosphorylation	EPARPPQTPGAPAGS CCCCCCCCCCCCCCC	29.48	27422710
322	Phosphorylation	TPGAPAGSLSRVNGA CCCCCCCCCHHCCCH	25.85	27080861
324	Phosphorylation	GAPAGSLSRVNGAGL CCCCCCCHHCCCHHH	35.56	27080861
337	Methylation	GLAQRLQRDLALDGG HHHHHHHHHHHHHHH	45.56	115390849
337	Dimethylation	GLAQRLQRDLALDGG HHHHHHHHHHHHHHH	45.56	-
350	Phosphorylation	GGLQRLLSSLRADPR HHHHHHHHHCCCCCC	31.73	17081983
351	Phosphorylation	GLQRLLSSLRADPRH HHHHHHHHCCCCCCC	23.11	25954137
359	Phosphorylation	LRADPRHSLALPPGG CCCCCCCCCCCCCCC	19.33	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR6G_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR6G_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR6G_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPCZ_HUMAN	PRKCZ	physical	11260256
RAC1_HUMAN	RAC1	physical	11260256
CDC42_HUMAN	CDC42	physical	11260256
KPCI_HUMAN	PRKCI	physical	14676191
PARD3_HUMAN	PARD3	physical	14676191
L2GL1_HUMAN	LLGL1	physical	14676191
1433E_HUMAN	YWHAE	physical	14676191
CDC42_HUMAN	CDC42	physical	14676191
PAR6B_HUMAN	PARD6B	physical	14676191
MARK2_HUMAN	MARK2	physical	14676191
L2GL2_HUMAN	LLGL2	physical	14676191
KPCZ_HUMAN	PRKCZ	physical	14676191
BRNP1_HUMAN	BRINP1	physical	14676191
HSP74_HUMAN	HSPA4	physical	14676191
PNMA3_HUMAN	PNMA3	physical	14676191
PNMA2_HUMAN	PNMA2	physical	14676191
PNM8A_HUMAN	PNMAL1	physical	14676191
WDR83_HUMAN	WDR83	physical	23439680

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.