PNM8A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PNM8A_HUMAN
• UniProt AC: Q86V59
• Protein Name: Paraneoplastic antigen-like protein 8A {ECO:0000312|HGNC:HGNC:25578}
• Gene Name: PNMA8A {ECO:0000312|HGNC:HGNC:25578}
• Organism: Homo sapiens (Human).
• Sequence Length: 439
• Protein Sequence: MSKTMAMNLLEDWCRGMEVDIHRSLLVTGIPEDCGQAEIEETLNGVLSPLGPYRVLNKIFVREENVKAALIEVGEGVNLSTIPREFPGRGGVWRVVCRDPTQDAEFLKNLNEFLDAEGRTWEDVVRLLQLNHPTLSQNQHQPPENWAEALGVLLGAVVQIIFCMDAEIRSREEARAQEAAEFEEMAAWALAAGRKVKKEPGLAAEVGSALKAETPNNWNATEDQHEPTKPLVRRAGAKSRSRRKKQKKNSRQEAVPWKKPKGINSNSTANLEDPEVGDAESMAISEPIKGSRKPCVNKEELALKKPMAKCAWKGPREPPQDARAEAESPGGASESDQDGGHESPPKKKAVAWVSAKNPAPMRKKKKVSLGPVSYVLVDSEDGRKKPVMPKKGPGSRREASDQKAPRGQQPAEATASTSRGPKAKPEGSPRRATNESRKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKTMAMNL ------CCHHHHHHH		30622161
4	Phosphorylation	----MSKTMAMNLLE ----CCHHHHHHHHH		30622161
58	Ubiquitination	GPYRVLNKIFVREEN CHHHHHHHEEECHHH		22053931
58 (in isoform 2)	Ubiquitination	-		21890473
58 (in isoform 1)	Ubiquitination	-		21890473
67	Ubiquitination	FVREENVKAALIEVG EECHHHHEEEEEECC		-
101	Phosphorylation	RVVCRDPTQDAEFLK EEEECCCCCCHHHHH		22210691
108	Ubiquitination	TQDAEFLKNLNEFLD CCCHHHHHHHHHHHC		22053931
108 (in isoform 2)	Ubiquitination	-		21890473
108 (in isoform 1)	Ubiquitination	-		21890473
198	Ubiquitination	AAGRKVKKEPGLAAE HHCCCCCCCCCHHHH		29967540
229	Ubiquitination	EDQHEPTKPLVRRAG CCCCCCCHHHHHHHC		22817900
229 (in isoform 1)	Ubiquitination	-		21890473
229 (in isoform 2)	Ubiquitination	-		21890473
250	Phosphorylation	RKKQKKNSRQEAVPW HHHHHHCCCCCCCCC		29978859
265	Phosphorylation	KKPKGINSNSTANLE CCCCCCCCCCCCCCC		-
289	Ubiquitination	MAISEPIKGSRKPCV HCCCCCCCCCCCCCC		-
328	Phosphorylation	DARAEAESPGGASES CHHHHHCCCCCCCCC		23927012
333	Phosphorylation	AESPGGASESDQDGG HCCCCCCCCCCCCCC		20363803
335	Phosphorylation	SPGGASESDQDGGHE CCCCCCCCCCCCCCC		23927012
343	Phosphorylation	DQDGGHESPPKKKAV CCCCCCCCCCCCCEE		20363803
356	Ubiquitination	AVAWVSAKNPAPMRK EEEEHHCCCCCCCCC		32015554
368	Phosphorylation	MRKKKKVSLGPVSYV CCCCCCEEECCEEEE		28122231
373	Phosphorylation	KVSLGPVSYVLVDSE CEEECCEEEEEEECC		30377224
374	Phosphorylation	VSLGPVSYVLVDSED EEECCEEEEEEECCC		30377224
379	Phosphorylation	VSYVLVDSEDGRKKP EEEEEEECCCCCCCC		30377224
395	Phosphorylation	MPKKGPGSRREASDQ CCCCCCCCCCCCCCC		-
428	Phosphorylation	PKAKPEGSPRRATNE CCCCCCCCCCCCCCC		26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PNM8A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PNM8A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PNM8A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.