| UniProt ID | PAR6B_HUMAN | |
|---|---|---|
| UniProt AC | Q9BYG5 | |
| Protein Name | Partitioning defective 6 homolog beta | |
| Gene Name | PARD6B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 372 | |
| Subcellular Localization | Cytoplasm. Cell membrane. Cell junction, tight junction. | |
| Protein Description | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.. | |
| Protein Sequence | MNRSHRHGAGSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFYGLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYSAFGTDTLIKKKNVLTNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSGQSTDNSLLGYPQQIEPSFEPEDEDSEEDDIIIEDNGVPQQIPKAVPNTESLESLTQIELSFESGQNGFIPSNEVSLAAIASSSNTEFETHAPDQKLLEEDGTIITL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MNRSHRHGAGS ----CCCCCCCCCCC | 21.62 | 29514088 | |
| 11 | Phosphorylation | SHRHGAGSGCLGTME CCCCCCCCCCCCCHH | 26.29 | 29255136 | |
| 16 | Phosphorylation | AGSGCLGTMEVKSKF CCCCCCCCHHHHHHH | 9.37 | 23927012 | |
| 22 | Ubiquitination | GTMEVKSKFGAEFRR CCHHHHHHHCCEEEE | 41.94 | 27667366 | |
| 31 | Phosphorylation | GAEFRRFSLERSKPG CCEEEEEEEECCCCC | 27.75 | 24425749 | |
| 44 | Phosphorylation | PGKFEEFYGLLQHVH CCCHHHHHHHHHHHH | 15.33 | 27642862 | |
| 62 | Phosphorylation | NVDVLVGYADIHGDL CCCEEEEEEECCCCE | 8.13 | 27642862 | |
| 78 | Phosphorylation | PINNDDNYHKAVSTA ECCCCCCHHHHHHCC | 16.22 | 27642862 | |
| 95 | Ubiquitination | LLRIFIQKKEEADYS HHHHHHCCHHHCCCC | 58.29 | 27667366 | |
| 101 | Phosphorylation | QKKEEADYSAFGTDT CCHHHCCCCCCCCCC | 14.67 | 21945579 | |
| 102 | Phosphorylation | KKEEADYSAFGTDTL CHHHCCCCCCCCCCH | 20.05 | 21945579 | |
| 106 | Phosphorylation | ADYSAFGTDTLIKKK CCCCCCCCCCHHEEC | 21.25 | 21945579 | |
| 108 | Phosphorylation | YSAFGTDTLIKKKNV CCCCCCCCHHEECCC | 30.16 | 25849741 | |
| 143 | Phosphorylation | PQDFRPVSSIIDVDI CCCCCCCCCEEEEEC | 20.64 | - | |
| 144 | Phosphorylation | QDFRPVSSIIDVDIL CCCCCCCCEEEEECC | 24.65 | - | |
| 162 | Acetylation | HRRVRLYKYGTEKPL CCCEEEEECCCCCCC | 41.62 | 25953088 | |
| 162 | Ubiquitination | HRRVRLYKYGTEKPL CCCEEEEECCCCCCC | 41.62 | 27667366 | |
| 163 | Phosphorylation | RRVRLYKYGTEKPLG CCEEEEECCCCCCCE | 18.74 | 21406692 | |
| 165 | Phosphorylation | VRLYKYGTEKPLGFY EEEEECCCCCCCEEE | 37.43 | 21406692 | |
| 167 | Ubiquitination | LYKYGTEKPLGFYIR EEECCCCCCCEEEEE | 45.43 | 27667366 | |
| 172 | Phosphorylation | TEKPLGFYIRDGSSV CCCCCEEEEECCCEE | 8.02 | 21406692 | |
| 177 | Phosphorylation | GFYIRDGSSVRVTPH EEEEECCCEEEECCC | 29.92 | 21406692 | |
| 178 | Phosphorylation | FYIRDGSSVRVTPHG EEEECCCEEEECCCC | 21.33 | 21406692 | |
| 182 | Phosphorylation | DGSSVRVTPHGLEKV CCCEEEECCCCCCCC | 10.06 | 21406692 | |
| 188 | Ubiquitination | VTPHGLEKVPGIFIS ECCCCCCCCCCEEEE | 59.79 | 23000965 | |
| 259 | Phosphorylation | RNNVVRNSRTSGSSG CCCEEECCCCCCCCC | 26.77 | 28102081 | |
| 283 | Phosphorylation | YPQQIEPSFEPEDED CCCCCCCCCCCCCCC | 29.47 | 28348404 | |
| 291 | Phosphorylation | FEPEDEDSEEDDIII CCCCCCCCCCCCEEE | 40.62 | 29496963 | |
| 316 | Phosphorylation | KAVPNTESLESLTQI CCCCCCCCHHHCEEE | 35.08 | 27251275 | |
| 349 | Phosphorylation | LAAIASSSNTEFETH HHHHHCCCCCCEECC | 45.32 | - | |
| 355 | Phosphorylation | SSNTEFETHAPDQKL CCCCCEECCCCCHHH | 28.76 | - | |
| 368 | Phosphorylation | KLLEEDGTIITL--- HHCCCCCCEEEC--- | 22.87 | 28102081 | |
| 371 | Phosphorylation | EEDGTIITL------ CCCCCEEEC------ | 23.67 | 28102081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAR6B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAR6B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAR6B_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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