dbPTM

ROBO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ROBO1_HUMAN
UniProt AC	Q9Y6N7
Protein Name	Roundabout homolog 1
Gene Name	ROBO1
Organism	Homo sapiens (Human).
Sequence Length	1651
Subcellular Localization	Cell membrane Single-pass type I membrane protein . Cell projection, axon . Detected at growth cones in thalamus neurons.
Protein Description	Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. [PubMed: 10102268]
Protein Sequence	MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	ERGNDHGTPIPTSDN CCCCCCCCCCCCCCC	18.02	-
75	Phosphorylation	PRIVEHPSDLIVSKG CCCCCCCCCEEEECC	47.13	23403867
80	Phosphorylation	HPSDLIVSKGEPATL CCCCEEEECCCCCEE	28.13	-
81	Ubiquitination	PSDLIVSKGEPATLN CCCEEEECCCCCEEC	57.30	-
81 (in isoform 2)	Ubiquitination	-	57.30	-
160	N-linked_Glycosylation	LGEAVSHNASLEVAI CCHHHHCCCEEEEEE	24.58	UniProtKB CARBOHYD
201	O-linked_Glycosylation	PRGHPEPTISWKKDG CCCCCCCCCEECCCC	26.44	OGP
209	Phosphorylation	ISWKKDGSPLDDKDE CEECCCCCCCCCCCC	32.21	26074081
219	Phosphorylation	DDKDERITIRGGKLM CCCCCCEEEECCEEE	15.73	26074081
228	Phosphorylation	RGGKLMITYTRKSDA ECCEEEEEEECCCCC	12.60	23663014
229	Phosphorylation	GGKLMITYTRKSDAG CCEEEEEEECCCCCC	8.14	23663014
230	Phosphorylation	GKLMITYTRKSDAGK CEEEEEEECCCCCCC	23.99	23663014
233	Phosphorylation	MITYTRKSDAGKYVC EEEEECCCCCCCEEE	29.42	21406692
238	Phosphorylation	RKSDAGKYVCVGTNM CCCCCCCEEEECCCC	9.73	21406692
243	Phosphorylation	GKYVCVGTNMVGERE CCEEEECCCCCCCCH	10.35	21406692
251	Phosphorylation	NMVGERESEVAELTV CCCCCCHHHEEEEEE	43.52	21406692
257	Phosphorylation	ESEVAELTVLERPSF HHHEEEEEEEECCCC	17.98	21406692
305	Phosphorylation	DDGELPKSRYEIRDD CCCCCCCCCEEECCC	37.85	-
307	Phosphorylation	GELPKSRYEIRDDHT CCCCCCCEEECCCCE	23.85	28152594
321	Phosphorylation	TLKIRKVTAGDMGSY EEEEEEEECCCCCCE	28.14	-
463	N-linked_Glycosylation	VIRQGPVNQTVAVDG CCCCCCCCCEEEECC	34.63	UniProtKB CARBOHYD
481	O-linked_Glycosylation	LSCVATGSPVPTILW EEEEECCCCCCEEEE	20.54	29351928
496	Phosphorylation	RKDGVLVSTQDSRIK ECCCEEEECCCHHHH	19.05	27134283
497	Phosphorylation	KDGVLVSTQDSRIKQ CCCEEEECCCHHHHH	28.99	23403867
500	Phosphorylation	VLVSTQDSRIKQLEN EEEECCCHHHHHHHC	26.53	27134283
520	Phosphorylation	RYAKLGDTGRYTCIA EEEECCCCCEEEEEE	23.04	-
555	O-linked_Glycosylation	PVQPPRPTDPNLIPS CCCCCCCCCCCCCCC	66.42	OGP
654	O-linked_Glycosylation	QISDPVKTQDVLPTS HCCCCCCCCCCCCCC	30.18	OGP
660	O-linked_Glycosylation	KTQDVLPTSQGVDHK CCCCCCCCCCCCCHH	29.53	55833261
661	O-linked_Glycosylation	TQDVLPTSQGVDHKQ CCCCCCCCCCCCHHH	24.01	55833267
743	Ubiquitination	VVIPDLRKGVNYEIK EECCCCCCCCCEEEE	74.61	-
750	Ubiquitination	KGVNYEIKARPFFNE CCCCEEEEECCCCHH	26.80	-
790	N-linked_Glycosylation	TVSKNDGNGTAILVS EEEEECCCCEEEEEE	47.72	UniProtKB CARBOHYD
820	N-linked_Glycosylation	YKVWCLGNETRYHIN EEEEECCCCEEEEEE	34.22	UniProtKB CARBOHYD
827	N-linked_Glycosylation	NETRYHINKTVDGST CCEEEEEEECCCCCE	22.19	UniProtKB CARBOHYD
848	Phosphorylation	FLVPGIRYSVEVAAS ECCCCCCEEEEEHHH	18.36	23403867
855	Phosphorylation	YSVEVAASTGAGSGV EEEEEHHHCCCCCCC	20.03	23403867
856	Phosphorylation	SVEVAASTGAGSGVK EEEEHHHCCCCCCCC	26.73	23403867
893 (in isoform 4)	Phosphorylation	-	4.65	-
901 (in isoform 4)	Phosphorylation	-	9.33	-
903 (in isoform 4)	Phosphorylation	-	2.22	-
903 (in isoform 5)	Phosphorylation	-	2.22	24719451
904 (in isoform 5)	Phosphorylation	-	13.25	24719451
905 (in isoform 4)	Phosphorylation	-	9.49	-
929	Phosphorylation	RKKRNGLTSTYAGIR HHHHCCCCCCCCCCC	22.03	26356563
930	Phosphorylation	KKRNGLTSTYAGIRK HHHCCCCCCCCCCCC	25.18	28355574
931	Phosphorylation	KRNGLTSTYAGIRKV HHCCCCCCCCCCCCC	16.50	26356563
932	Phosphorylation	RNGLTSTYAGIRKVP HCCCCCCCCCCCCCC	11.55	25159151
936 (in isoform 2)	Phosphorylation	-	32.76	27642862
937	Ubiquitination	STYAGIRKVPSFTFT CCCCCCCCCCEEEEC	57.48	-
940	Phosphorylation	AGIRKVPSFTFTPTV CCCCCCCEEEECCEE	39.65	22167270
942	Phosphorylation	IRKVPSFTFTPTVTY CCCCCEEEECCEEEE	30.82	30266825
944	Phosphorylation	KVPSFTFTPTVTYQR CCCEEEECCEEEEEE	18.26	30266825
944 (in isoform 2)	Phosphorylation	-	18.26	27642862
946	Phosphorylation	PSFTFTPTVTYQRGG CEEEECCEEEEEECC	23.56	23927012
946 (in isoform 2)	Phosphorylation	-	23.56	21406692
948	Phosphorylation	FTFTPTVTYQRGGEA EEECCEEEEEECCEE	19.20	23927012
949	Phosphorylation	TFTPTVTYQRGGEAV EECCEEEEEECCEEE	7.59	23403867
953 (in isoform 2)	Phosphorylation	-	23.14	27642862
957	Phosphorylation	QRGGEAVSSGGRPGL EECCEEECCCCCCCC	30.25	22210691
1006	Ubiquitination	NGNSDSNLTTYSRPA CCCCCCCCCCCCCCH	4.36	21890473
1006	Ubiquitination	NGNSDSNLTTYSRPA CCCCCCCCCCCCCCH	4.36	21890473
1015 (in isoform 3)	Ubiquitination	-	3.25	21890473
1016 (in isoform 4)	Phosphorylation	-	2.61	-
1019	Phosphorylation	PADCIANYNNQLDNK CHHHHHCCCCCCCCC	13.38	25884760
1023 (in isoform 2)	Phosphorylation	-	9.47	27642862
1026	Ubiquitination	YNNQLDNKQTNLMLP CCCCCCCCCCCCCCC	59.16	-
1038	Phosphorylation	MLPESTVYGDVDLSN CCCCCCEECCCCCHH	14.01	25884760
1042 (in isoform 2)	Phosphorylation	-	49.47	27642862
1044	Phosphorylation	VYGDVDLSNKINEMK EECCCCCHHHHHCCC	31.45	29978859
1046	Ubiquitination	GDVDLSNKINEMKTF CCCCCHHHHHCCCCC	43.46	-
1051	Ubiquitination	SNKINEMKTFNSPNL HHHHHCCCCCCCCCC	43.73	2189047
1051 (in isoform 1)	Ubiquitination	-	43.73	21890473
1052	Phosphorylation	NKINEMKTFNSPNLK HHHHCCCCCCCCCCC	27.09	30266825
1055	Phosphorylation	NEMKTFNSPNLKDGR HCCCCCCCCCCCCCC	15.80	19664994
1055 (in isoform 2)	Ubiquitination	-	15.80	21890473
1059	Ubiquitination	TFNSPNLKDGRFVNP CCCCCCCCCCCEECC	65.85	-
1063 (in isoform 2)	Ubiquitination	-	8.34	-
1071	Phosphorylation	VNPSGQPTPYATTQL ECCCCCCCCCHHHHH	22.50	26356563
1073	Phosphorylation	PSGQPTPYATTQLIQ CCCCCCCCHHHHHHH	21.04	25884760
1075	Phosphorylation	GQPTPYATTQLIQSN CCCCCCHHHHHHHHH	14.83	25884760
1075 (in isoform 4)	Phosphorylation	-	14.83	-
1076	Phosphorylation	QPTPYATTQLIQSNL CCCCCHHHHHHHHHC	17.13	26356563
1081	Phosphorylation	ATTQLIQSNLSNNMN HHHHHHHHHCCCCCC	32.51	26356563
1084	Phosphorylation	QLIQSNLSNNMNNGS HHHHHHCCCCCCCCC	30.34	26356563
1087 (in isoform 4)	Phosphorylation	-	4.88	-
1091	Phosphorylation	SNNMNNGSGDSGEKH CCCCCCCCCCCCCCC	41.36	26356563
1094	Phosphorylation	MNNGSGDSGEKHWKP CCCCCCCCCCCCCCC	52.99	26356563
1100	Ubiquitination	DSGEKHWKPLGQQKQ CCCCCCCCCCCHHCC	30.04	-
1106	Ubiquitination	WKPLGQQKQEVAPVQ CCCCCHHCCCCCCCE	40.30	-
1110 (in isoform 2)	Ubiquitination	-	9.59	-
1114	Phosphorylation	QEVAPVQYNIVEQNK CCCCCCEEEEHHHCC	13.69	21945579
1118 (in isoform 2)	Phosphorylation	-	44.64	27642862
1121	Ubiquitination	YNIVEQNKLNKDYRA EEEHHHCCCCCCCCC	53.80	-
1126	Phosphorylation	QNKLNKDYRANDTVP HCCCCCCCCCCCCCC	17.15	20068231
1131	Phosphorylation	KDYRANDTVPPTIPY CCCCCCCCCCCCCCC	34.42	22210691
1141	Phosphorylation	PTIPYNQSYDQNTGG CCCCCCCCCCCCCCC	27.34	21955146
1142	Phosphorylation	TIPYNQSYDQNTGGS CCCCCCCCCCCCCCC	16.28	21955146
1146	Phosphorylation	NQSYDQNTGGSYNSS CCCCCCCCCCCCCCC	36.97	21955146
1149	Phosphorylation	YDQNTGGSYNSSDRG CCCCCCCCCCCCCCC	23.61	21955146
1150	Phosphorylation	DQNTGGSYNSSDRGS CCCCCCCCCCCCCCC	23.49	21955146
1152	Phosphorylation	NTGGSYNSSDRGSST CCCCCCCCCCCCCCC	25.94	29116813
1153	Phosphorylation	TGGSYNSSDRGSSTS CCCCCCCCCCCCCCC	27.91	21955146
1159	Phosphorylation	SSDRGSSTSGSQGHK CCCCCCCCCCCCCCC	38.51	22210691
1162	Phosphorylation	RGSSTSGSQGHKKGA CCCCCCCCCCCCCCC	32.53	22210691
1171	Phosphorylation	GHKKGARTPKVPKQG CCCCCCCCCCCCCCC	27.25	23898821
1201 (in isoform 4)	Phosphorylation	-	43.64	-
1224	Phosphorylation	PVPPARMYLQQDELE CCCCHHEEECHHHHH	8.87	29978859
1228 (in isoform 2)	Phosphorylation	-	49.87	27642862
1237	Methylation	LEEEEDERGPTPPVR HHHHHHHCCCCCCCC	69.57	115491483
1240	Phosphorylation	EEDERGPTPPVRGAA HHHHCCCCCCCCCCC	42.94	30266825
1244 (in isoform 2)	Phosphorylation	-	34.50	27642862
1258 (in isoform 4)	Phosphorylation	-	36.21	-
1259	Phosphorylation	AVSYSHQSTATLTPS EECCCCCCCCCCCCC	18.00	24275569
1260	Phosphorylation	VSYSHQSTATLTPSP ECCCCCCCCCCCCCC	19.66	24275569
1262	Phosphorylation	YSHQSTATLTPSPQE CCCCCCCCCCCCCHH	31.11	24275569
1264	Phosphorylation	HQSTATLTPSPQEEL CCCCCCCCCCCHHHH	19.84	24275569
1266	Phosphorylation	STATLTPSPQEELQP CCCCCCCCCHHHHHH	33.70	24275569
1267 (in isoform 4)	Phosphorylation	-	46.97	-
1272 (in isoform 4)	Phosphorylation	-	25.33	-
1297	Phosphorylation	DRRRQPVSPPPPPRP CCCCCCCCCCCCCCC	38.07	30576142
1301 (in isoform 2)	Phosphorylation	-	43.22	21406692
1306	Phosphorylation	PPPPRPISPPHTYGY CCCCCCCCCCCCCCC	34.75	30576142
1310	Phosphorylation	RPISPPHTYGYISGP CCCCCCCCCCCCCCC	25.15	21406692
1310 (in isoform 2)	Phosphorylation	-	25.15	21406692
1311	Phosphorylation	PISPPHTYGYISGPL CCCCCCCCCCCCCCC	12.61	30576142
1313	Phosphorylation	SPPHTYGYISGPLVS CCCCCCCCCCCCCCC	4.98	21406692
1314 (in isoform 2)	Phosphorylation	-	3.13	21406692
1315	Phosphorylation	PHTYGYISGPLVSDM CCCCCCCCCCCCCCC	26.35	21406692
1320	Phosphorylation	YISGPLVSDMDTDAP CCCCCCCCCCCCCCC	34.59	21406692
1324	Phosphorylation	PLVSDMDTDAPEEEE CCCCCCCCCCCHHHH	27.68	21406692
1388	Phosphorylation	DNISSGRSSVSSSDG CCCCCCCCCCCCCCC	38.32	30177828
1389	Phosphorylation	NISSGRSSVSSSDGS CCCCCCCCCCCCCCC	25.34	30177828
1391	Phosphorylation	SSGRSSVSSSDGSFF CCCCCCCCCCCCCCC	26.52	30177828
1392	Phosphorylation	SGRSSVSSSDGSFFT CCCCCCCCCCCCCCC	30.23	30177828
1393	Phosphorylation	GRSSVSSSDGSFFTD CCCCCCCCCCCCCCC	38.18	30177828
1396	Phosphorylation	SVSSSDGSFFTDADF CCCCCCCCCCCCHHH	23.37	20068231
1396 (in isoform 4)	Phosphorylation	-	23.37	-
1399	Phosphorylation	SSDGSFFTDADFAQA CCCCCCCCCHHHHHH	28.41	30177828
1413	Phosphorylation	AVAAAAEYAGLKVAR HHHHHHHHHCHHHHH	10.97	25884760
1435	Phosphorylation	GRRHFHASQCPRPTS HCCCCCHHHCCCCCC	24.60	23927012
1441	Phosphorylation	ASQCPRPTSPVSTDS HHHCCCCCCCCCCCC	47.12	29255136
1442	Phosphorylation	SQCPRPTSPVSTDSN HHCCCCCCCCCCCCC	26.45	29255136
1445	Phosphorylation	PRPTSPVSTDSNMSA CCCCCCCCCCCCHHH	29.85	30576142
1446	Phosphorylation	RPTSPVSTDSNMSAA CCCCCCCCCCCHHHH	43.62	30576142
1448	Phosphorylation	TSPVSTDSNMSAAVM CCCCCCCCCHHHHHH	34.22	30576142
1451	Phosphorylation	VSTDSNMSAAVMQKT CCCCCCHHHHHHHCC	19.82	30576142
1453 (in isoform 4)	Phosphorylation	-	7.04	-
1455 (in isoform 4)	Phosphorylation	-	2.65	-
1465	Ubiquitination	TRPAKKLKHQPGHLR CCCCHHHCCCCCCCC	49.42	-
1475	Phosphorylation	PGHLRRETYTDDLPP CCCCCCCCCCCCCCC	29.88	23403867
1476	Phosphorylation	GHLRRETYTDDLPPP CCCCCCCCCCCCCCC	11.92	25884760
1477	Phosphorylation	HLRRETYTDDLPPPP CCCCCCCCCCCCCCC	30.38	23403867
1480 (in isoform 2)	Phosphorylation	-	8.36	27642862
1492	Phosphorylation	VPPPAIKSPTAQSKT CCCCCCCCCCCCCCC	22.75	25159151
1494	Phosphorylation	PPAIKSPTAQSKTQL CCCCCCCCCCCCCEE	44.41	21712546
1497	Phosphorylation	IKSPTAQSKTQLEVR CCCCCCCCCCEEEEE	34.90	22617229
1513	Phosphorylation	VVVPKLPSMDARTDR EECCCCCCCCCCCCC	39.47	27470641
1528	Phosphorylation	SSDRKGSSYKGREVL CCCCCCCCCCCCEEE	39.26	16674116
1545	Phosphorylation	RQVVDMRTNPGDPRE CEEEECCCCCCCHHH	38.84	27470641
1565 (in isoform 4)	Phosphorylation	-	29.45	-
1567 (in isoform 4)	Phosphorylation	-	23.40	-
1587	Phosphorylation	IQEDILPYCRPTFPT HHCCCHHHCCCCCCC	9.54	26356563
1591	Phosphorylation	ILPYCRPTFPTSNNP CHHHCCCCCCCCCCC	23.93	26356563
1591 (in isoform 2)	Phosphorylation	-	23.93	27642862
1594	Phosphorylation	YCRPTFPTSNNPRDP HCCCCCCCCCCCCCC	39.64	26356563
1595	Phosphorylation	CRPTFPTSNNPRDPS CCCCCCCCCCCCCCC	34.54	26356563
1602	Phosphorylation	SNNPRDPSSSSSMSS CCCCCCCCCCCCCCC	47.33	21406692
1603	Phosphorylation	NNPRDPSSSSSMSSR CCCCCCCCCCCCCCC	39.36	20068231
1604	Phosphorylation	NPRDPSSSSSMSSRG CCCCCCCCCCCCCCC	30.67	20068231
1605	Phosphorylation	PRDPSSSSSMSSRGS CCCCCCCCCCCCCCC	31.82	20068231
1606	Phosphorylation	RDPSSSSSMSSRGSG CCCCCCCCCCCCCCC	25.32	20068231
1608	Phosphorylation	PSSSSSMSSRGSGSR CCCCCCCCCCCCCHH	20.87	20068231
1609	Phosphorylation	SSSSSMSSRGSGSRQ CCCCCCCCCCCCHHH	31.83	25159151
1612	Phosphorylation	SSMSSRGSGSRQREQ CCCCCCCCCHHHHHH	32.27	20068231
1614	Phosphorylation	MSSRGSGSRQREQAN CCCCCCCHHHHHHHC	27.26	21406692
1618 (in isoform 2)	Phosphorylation	-	45.78	21406692
1640 (in isoform 2)	Phosphorylation	-	64.88	27642862
1649	Phosphorylation	NNEELEETES----- CHHHHHHHCC-----	31.95	23312004
1651	Phosphorylation	EELEETES------- HHHHHHCC-------	53.60	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1038	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
1038	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
1073	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
1073	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS
1114	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
1114	Y	Phosphorylation	Kinase	ABL-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ROBO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ROBO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP33_HUMAN	USP33	physical	19684588
UBP33_HUMAN	USP33	physical	19706539
ARP19_HUMAN	ARPP19	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ROBO1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940; SER-1055 ANDTHR-1240, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940 AND THR-1240, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Repulsive axon guidance: Abelson and Enabled play opposing rolesdownstream of the roundabout receptor."; Bashaw G.J., Kidd T., Murray D., Pawson T., Goodman C.S.; Cell 101:703-715(2000). Cited for: PHOSPHORYLATION AT TYR-1038; TYR-1073 AND TYR-1114.	10892742 [Abstract]