dbPTM

MSD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSD4_HUMAN
UniProt AC	Q8NCY6
Protein Name	Myb/SANT-like DNA-binding domain-containing protein 4
Gene Name	MSANTD4
Organism	Homo sapiens (Human).
Sequence Length	345
Subcellular Localization
Protein Description
Protein Sequence	MKQLKRKRKSNFSVQETQTLLKEITKRKEVIFSKQLNTTINVMKRMAWEEIAQCVNAVGEGEQRTGTEVKRRYLDWRALMKRKRMKANIKLVGSGFPLPSSDLDDSLTEEIDEKIGFRNDANFDWQNVADFRDAGGSLTEVKVEEEERDPQSPEFEIEEEEEMLSSVIPDSRRENELPDFPHIDEFFTLNSTPSRSAYDEPHLLVNIEKQKLELEKRRLDIEAERLQVEKERLQIEKERLRHLDMEHERLQLEKERLQIEREKLRLQIVNSEKPSLENELGQGEKSMLQPQDIETEKLKLERERLQLEKDRLQFLKFESEKLQIEKERLQVEKDRLRIQKEGHLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Ubiquitination	KQLKRKRKSNFSVQE HHHHHHHHCCCCHHH	53.43	-
9	Sumoylation	KQLKRKRKSNFSVQE HHHHHHHHCCCCHHH	53.43	28112733
10	Phosphorylation	QLKRKRKSNFSVQET HHHHHHHCCCCHHHH	47.33	25159151
22	Ubiquitination	QETQTLLKEITKRKE HHHHHHHHHHHHCCC	50.62	-
28	Ubiquitination	LKEITKRKEVIFSKQ HHHHHHCCCEEEECH	58.87	-
33	Phosphorylation	KRKEVIFSKQLNTTI HCCCEEEECHHHHHH	14.36	24719451
44	Ubiquitination	NTTINVMKRMAWEEI HHHHHHHHHHHHHHH	34.44	29967540
65	Phosphorylation	VGEGEQRTGTEVKRR HCCCCCCCCHHHHHH	48.42	-
73	Phosphorylation	GTEVKRRYLDWRALM CHHHHHHHHCHHHHH	17.04	22817900
90	Methylation	KRMKANIKLVGSGFP HHHHCCEEECCCCCC	36.61	23644510
94	Phosphorylation	ANIKLVGSGFPLPSS CCEEECCCCCCCCCC	29.76	30108239
100	Phosphorylation	GSGFPLPSSDLDDSL CCCCCCCCCCCCCHH	44.14	28176443
101	Phosphorylation	SGFPLPSSDLDDSLT CCCCCCCCCCCCHHH	40.01	30278072
106	Phosphorylation	PSSDLDDSLTEEIDE CCCCCCCHHHHHHHH	36.54	30278072
108	Phosphorylation	SDLDDSLTEEIDEKI CCCCCHHHHHHHHHH	35.21	28176443
114	Methylation	LTEEIDEKIGFRNDA HHHHHHHHHCCCCCC	44.36	23644510
114	Ubiquitination	LTEEIDEKIGFRNDA HHHHHHHHHCCCCCC	44.36	29967540
114	Sumoylation	LTEEIDEKIGFRNDA HHHHHHHHHCCCCCC	44.36	28112733
137	Phosphorylation	DFRDAGGSLTEVKVE HHHHCCCCEEEEEEC	31.06	23663014
139	Phosphorylation	RDAGGSLTEVKVEEE HHCCCCEEEEEECHH	40.19	23663014
142	Sumoylation	GGSLTEVKVEEEERD CCCEEEEEECHHHCC	37.38	28112733
152	Phosphorylation	EEERDPQSPEFEIEE HHHCCCCCCCCCHHH	31.61	28192239
165	Phosphorylation	EEEEEMLSSVIPDSR HHHHHHHHHHCCCCC	22.65	22210691
166	Phosphorylation	EEEEMLSSVIPDSRR HHHHHHHHHCCCCCC	21.80	22210691
188	Phosphorylation	PHIDEFFTLNSTPSR CCCCCCEECCCCCCC	30.28	28112733
191	Phosphorylation	DEFFTLNSTPSRSAY CCCEECCCCCCCCCC	44.82	26074081
192	Phosphorylation	EFFTLNSTPSRSAYD CCEECCCCCCCCCCC	24.98	25159151
194	Phosphorylation	FTLNSTPSRSAYDEP EECCCCCCCCCCCCC	38.67	26074081
198	Phosphorylation	STPSRSAYDEPHLLV CCCCCCCCCCCCEEE	23.29	27642862
209	Ubiquitination	HLLVNIEKQKLELEK CEEEEHHHHHHHHHH	49.27	29967540
237	Sumoylation	KERLQIEKERLRHLD HHHHHHHHHHHHHCH	50.17	28112733
254	Sumoylation	HERLQLEKERLQIER HHHHHHHHHHHHHHH	57.64	28112733
273	Sumoylation	LQIVNSEKPSLENEL HHHHHCCCCHHHHCC	39.46	28112733
273	Ubiquitination	LQIVNSEKPSLENEL HHHHHCCCCHHHHCC	39.46	29967540
285	Ubiquitination	NELGQGEKSMLQPQD HCCCCCCCCCCCCCC	48.25	29967540
286	Phosphorylation	ELGQGEKSMLQPQDI CCCCCCCCCCCCCCH	22.03	25159151
297	Methylation	PQDIETEKLKLERER CCCHHHHHHHHHHHH	59.34	23644510
319	Phosphorylation	LQFLKFESEKLQIEK HHHHHHHHHCHHHHH	43.07	22817900
340	Ubiquitination	KDRLRIQKEGHLQ-- HHHHHHHHCCCCC--	64.39	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSD4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MSD4_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSD4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-188, AND MASSSPECTROMETRY.	18220336 [Abstract]