PTN21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTN21_HUMAN
• UniProt AC: Q16825
• Protein Name: Tyrosine-protein phosphatase non-receptor type 21
• Gene Name: PTPN21
• Organism: Homo sapiens (Human).
• Sequence Length: 1174
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDNLFVPNQNGYYCHSQTSLDRAQIDLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSITGSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSSYAYSRPAALVYSQPEIREHAQLPSPAAAHCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPELTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLSRHLYISSSNPDLITRRVHHSVQTFQEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLSHGLEGLRLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPEEAEGLRYGHKKSLSDATMLIHSSEEEEDEDFEEESGARAPPARAREPRPGLAQDPPGCPRVLLAGPLHILEPKAHVPDAEKRMMDSSPVRTTAEAQRPWRDGLLMPSMSESDLTTSGRYRARRDSLKKRPVSDLLSGKKNIVEGLPPLGGMKKTRVDAKKIGPLKLAALNGLSLSRVPLPDEGKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
284	Phosphorylation	EETIQFQTEDMETAK CCEEEEECCCHHHHH	34.93	-
292	Phosphorylation	EDMETAKYIWRLCVA CCHHHHHHHHHHHHH	11.85	28152594
483	Phosphorylation	NIGSSYAYSRPAALV CCCCCCCCCCCEEEE	9.29	27642862
491	Phosphorylation	SRPAALVYSQPEIRE CCCEEEEECCHHHHH	11.48	27732954
492	Phosphorylation	RPAALVYSQPEIREH CCEEEEECCHHHHHH	31.60	29255136
504	Phosphorylation	REHAQLPSPAAAHCP HHHCCCCCCHHHCCC	35.44	27422710
513	Phosphorylation	AAAHCPFSLSYSFHS HHHCCCCEEEEEECC	11.10	28348404
515	Phosphorylation	AHCPFSLSYSFHSPS HCCCCEEEEEECCCC	19.96	28348404
516	Phosphorylation	HCPFSLSYSFHSPSP CCCCEEEEEECCCCC	22.20	28348404
517	Phosphorylation	CPFSLSYSFHSPSPY CCCEEEEEECCCCCC	17.07	28348404
538	Phosphorylation	RPVVGAVSVPELTNA CCCEEEEEHHHHCCH	31.27	26657352
543	Phosphorylation	AVSVPELTNAQLQAQ EEEHHHHCCHHHHCC	27.18	22199227
552	Phosphorylation	AQLQAQDYPSPNIMR HHHHCCCCCCCCCCC	8.11	22199227
554	Phosphorylation	LQAQDYPSPNIMRTQ HHCCCCCCCCCCCCE	25.09	27251275
560	Phosphorylation	PSPNIMRTQVYRPPP CCCCCCCCEEECCCC	12.66	23312004
563	Phosphorylation	NIMRTQVYRPPPPYP CCCCCEEECCCCCCC	13.95	23312004
569	Phosphorylation	VYRPPPPYPPPRPAN EECCCCCCCCCCCCC	33.86	22817900
577	Phosphorylation	PPPRPANSTPDLSRH CCCCCCCCCCCHHHC	43.34	29255136
578	Phosphorylation	PPRPANSTPDLSRHL CCCCCCCCCCHHHCE	22.19	29255136
582	Phosphorylation	ANSTPDLSRHLYISS CCCCCCHHHCEEECC	25.65	29523821
586	Phosphorylation	PDLSRHLYISSSNPD CCHHHCEEECCCCHH	7.82	23403867
588	Phosphorylation	LSRHLYISSSNPDLI HHHCEEECCCCHHHH	17.73	30266825
589	Phosphorylation	SRHLYISSSNPDLIT HHCEEECCCCHHHHH	25.28	30266825
590	Phosphorylation	RHLYISSSNPDLITR HCEEECCCCHHHHHH	45.66	30266825
596	Phosphorylation	SSNPDLITRRVHHSV CCCHHHHHHHHHHHC	21.51	23403867
602	Phosphorylation	ITRRVHHSVQTFQED HHHHHHHHCHHCCCC	10.88	27732954
605	Phosphorylation	RVHHSVQTFQEDSLP HHHHHCHHCCCCCCC	25.73	27732954
610	Phosphorylation	VQTFQEDSLPVAHSL CHHCCCCCCCCCCCH	33.54	27732954
616	Phosphorylation	DSLPVAHSLQEVSEP CCCCCCCCHHHCCCH	23.24	29255136
621	Phosphorylation	AHSLQEVSEPLTAAR CCCHHHCCCHHHHHH	32.51	27732954
625	Phosphorylation	QEVSEPLTAARHAQL HHCCCHHHHHHHHHH	29.05	27732954
637	Phosphorylation	AQLHKRNSIEVAGLS HHHHHCCCEECCCCC	24.94	30266825
644	Phosphorylation	SIEVAGLSHGLEGLR CEECCCCCCCCHHHH	18.00	23403867
656	Phosphorylation	GLRLKERTLSASAAE HHHCCCCCCCCHHHH	26.59	26657352
658	Phosphorylation	RLKERTLSASAAEVA HCCCCCCCCHHHHHH	21.40	30266825
660	Phosphorylation	KERTLSASAAEVAPR CCCCCCCHHHHHHCC	25.33	30266825
670	Phosphorylation	EVAPRAVSVGSQPSV HHHCCEEECCCCCCC	21.56	30266825
673	Phosphorylation	PRAVSVGSQPSVFTE CCEEECCCCCCCCCC	36.44	30266825
676	Phosphorylation	VSVGSQPSVFTERTQ EECCCCCCCCCCCCC	23.40	30266825
679	Phosphorylation	GSQPSVFTERTQREG CCCCCCCCCCCCCCC	23.54	24719451
700	Phosphorylation	LRYGHKKSLSDATML CCCCCCCCCCCCEEE	37.60	27732954
702	Phosphorylation	YGHKKSLSDATMLIH CCCCCCCCCCEEECC	32.08	27732954
705	Phosphorylation	KKSLSDATMLIHSSE CCCCCCCEEECCCCC	19.94	22617229
710	Phosphorylation	DATMLIHSSEEEEDE CCEEECCCCCCHHCC	32.24	22777824
711	Phosphorylation	ATMLIHSSEEEEDED CEEECCCCCCHHCCC	34.56	22777824
723	Phosphorylation	DEDFEEESGARAPPA CCCCHHHCCCCCCCC	40.82	27732954
774	Phosphorylation	AEKRMMDSSPVRTTA HHHHCCCCCCCCCCH	20.74	23090842
775	Phosphorylation	EKRMMDSSPVRTTAE HHHCCCCCCCCCCHH	24.13	28985074
795	Phosphorylation	RDGLLMPSMSESDLT CCCCCCCCCCHHHCC	22.45	30266825
797	Phosphorylation	GLLMPSMSESDLTTS CCCCCCCCHHHCCCC	37.98	30266825
799	Phosphorylation	LMPSMSESDLTTSGR CCCCCCHHHCCCCCC	30.52	30266825
802	Phosphorylation	SMSESDLTTSGRYRA CCCHHHCCCCCCHHH	24.73	30266825
803	Phosphorylation	MSESDLTTSGRYRAR CCHHHCCCCCCHHHC	36.16	30266825
804	Phosphorylation	SESDLTTSGRYRARR CHHHCCCCCCHHHCH	18.94	30266825
820	Phosphorylation	SLKKRPVSDLLSGKK HHHCCCHHHHHCCCC	25.81	29978859
861	Phosphorylation	LAALNGLSLSRVPLP HHHHCCCCCCCCCCC	26.20	29514088
863	Phosphorylation	ALNGLSLSRVPLPDE HHCCCCCCCCCCCCC	28.05	27050516
915	Phosphorylation	LVDGECSTARLPENA CCCCCCCCCCCCCHH	27.70	-
1020	Phosphorylation	RLGSRHNTVTYGRFK CCCCCCCEEEECEEE	14.22	30278072
1157	Phosphorylation	LVQTLCQYTFVYRVL HHHHHHHHHHHHHHH	10.93	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTN21_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTN21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTN21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMX_HUMAN	BMX	physical	11013262
KIF1C_HUMAN	KIF1C	physical	9685376
AJUBA_HUMAN	AJUBA	physical	27880917
LPP_HUMAN	LPP	physical	27880917
PFD4_HUMAN	PFDN4	physical	27880917
PFD6_HUMAN	PFDN6	physical	27880917
TRIP6_HUMAN	TRIP6	physical	27880917
USP9X_HUMAN	USP9X	physical	27880917
PFD3_HUMAN	VBP1	physical	27880917
WWC2_HUMAN	WWC2	physical	27880917
KIBRA_HUMAN	WWC1	physical	27432908
PTN21_HUMAN	PTPN21	physical	27432908
NEK7_HUMAN	NEK7	physical	27432908
P20D2_HUMAN	PM20D2	physical	27432908
TRIP6_HUMAN	TRIP6	physical	27432908
RMD5A_HUMAN	RMND5A	physical	27432908
IFT52_HUMAN	IFT52	physical	27432908
AMOT_HUMAN	AMOT	physical	27432908
WWC2_HUMAN	WWC2	physical	27432908
WDR5_HUMAN	WDR5	physical	27432908
IFT56_HUMAN	TTC26	physical	27432908
DCAF8_HUMAN	DCAF8	physical	27432908
CSK22_HUMAN	CSNK2A2	physical	27432908
RPA2_HUMAN	POLR1B	physical	27432908
WDR26_HUMAN	WDR26	physical	27432908
SAHH3_HUMAN	AHCYL2	physical	27432908
BPIB1_HUMAN	BPIFB1	physical	27432908
NAF1_HUMAN	NAF1	physical	27432908
CSK21_HUMAN	CSNK2A1	physical	27432908
ARK72_HUMAN	AKR7A2	physical	27432908
ARMC8_HUMAN	ARMC8	physical	27432908
DCAF5_HUMAN	DCAF5	physical	27432908
ELP2_HUMAN	ELP2	physical	27432908
STXB4_HUMAN	STXBP4	physical	27432908
ACAD8_HUMAN	ACAD8	physical	27432908
SAHH2_HUMAN	AHCYL1	physical	27432908
RPAC1_HUMAN	POLR1C	physical	27432908
TMX3_HUMAN	TMX3	physical	27432908
CDK4_HUMAN	CDK4	physical	27432908
DJB11_HUMAN	DNAJB11	physical	27432908
NDUA9_HUMAN	NDUFA9	physical	27432908
DUS7_HUMAN	DUSP7	physical	27432908
WWP1_HUMAN	WWP1	physical	27432908

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.