ARK72_HUMAN - dbPTM
ARK72_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARK72_HUMAN
UniProt AC O43488
Protein Name Aflatoxin B1 aldehyde reductase member 2
Gene Name AKR7A2
Organism Homo sapiens (Human).
Sequence Length 359
Subcellular Localization Golgi apparatus. Cytoplasm .
Protein Description Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen..
Protein Sequence MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationSAASRVVSRAAVHCA
CHHHHHHHHHHHHHH		17.22-
20PhosphorylationAVHCALRSPPPEARA
HHHHHHCCCCHHHHH		42.4826657352
31PhosphorylationEARALAMSRPPPPRV
HHHHHHHCCCCCHHH		35.7126657352
40PhosphorylationPPPPRVASVLGTMEM
CCCHHHHHHHCCHHH		18.2819060867
51SulfoxidationTMEMGRRMDAPASAA
CHHHHHCCCCHHHHH		5.0621406390
56PhosphorylationRRMDAPASAAAVRAF
HCCCCHHHHHHHHHH		19.8521406692
61MethylationPASAAAVRAFLERGH
HHHHHHHHHHHHCCC		18.20-
78PhosphorylationLDTAFMYSDGQSETI
CEEEEECCCCCCCEE		24.3950564499
105UbiquitinationCRVKIATKANPWDGK
EEEEEEECCCCCCCC		36.82-
105AcetylationCRVKIATKANPWDGK
EEEEEEECCCCCCCC		36.8225953088
112UbiquitinationKANPWDGKSLKPDSV
CCCCCCCCCCCHHHH		50.58-
113PhosphorylationANPWDGKSLKPDSVR
CCCCCCCCCCHHHHH		47.3426437602
115UbiquitinationPWDGKSLKPDSVRSQ
CCCCCCCCHHHHHHH		54.60-
118PhosphorylationGKSLKPDSVRSQLET
CCCCCHHHHHHHHHH		28.1423312004
121PhosphorylationLKPDSVRSQLETSLK
CCHHHHHHHHHHHHH		36.6426437602
128UbiquitinationSQLETSLKRLQCPQV
HHHHHHHHHHCCCCE		51.322190698
128AcetylationSQLETSLKRLQCPQV
HHHHHHHHHHCCCCE		51.3225953088
223PhosphorylationRHFGLRFYAYNPLAG
HHHCCEEEEECCCCC		11.1820090780
225PhosphorylationFGLRFYAYNPLAGGL
HCCEEEEECCCCCCC		13.1120090780
236UbiquitinationAGGLLTGKYKYEDKD
CCCCCCEEEEEECCC		33.0821890473
236SuccinylationAGGLLTGKYKYEDKD
CCCCCCEEEEEECCC		33.08-
236AcetylationAGGLLTGKYKYEDKD
CCCCCCEEEEEECCC		33.0825953088
236SuccinylationAGGLLTGKYKYEDKD
CCCCCCEEEEEECCC		33.0821890473
238AcetylationGLLTGKYKYEDKDGK
CCCCEEEEEECCCCC		45.7226051181
239PhosphorylationLLTGKYKYEDKDGKQ
CCCEEEEEECCCCCC		26.6926657352
250MethylationDGKQPVGRFFGNSWA
CCCCCCHHHCCCCHH		24.77-
255PhosphorylationVGRFFGNSWAETYRN
CHHHCCCCHHHHHHH		28.2122617229
259PhosphorylationFGNSWAETYRNRFWK
CCCCHHHHHHHHHHH		21.7520068231
260PhosphorylationGNSWAETYRNRFWKE
CCCHHHHHHHHHHHH		9.4424117733
284PhosphorylationEKALQAAYGASAPSV
HHHHHHHHCCCCCHH		19.0825867546
287PhosphorylationLQAAYGASAPSVTSA
HHHHHCCCCCHHHHH		36.0320068231
290PhosphorylationAYGASAPSVTSAALR
HHCCCCCHHHHHHHH		37.4325867546
292PhosphorylationGASAPSVTSAALRWM
CCCCCHHHHHHHHHH		19.5825867546
293PhosphorylationASAPSVTSAALRWMY
CCCCHHHHHHHHHHH		14.9125867546
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARK72_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARK72_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARK72_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARK73_HUMANAKR7A3physical
16189514
ARK72_HUMANAKR7A2physical
25416956
DUS12_HUMANDUSP12physical
26344197
PRS4_HUMANPSMC1physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARK72_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND MASSSPECTROMETRY.

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