ARK73_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARK73_HUMAN
• UniProt AC: O95154
• Protein Name: Aflatoxin B1 aldehyde reductase member 3
• Gene Name: AKR7A3
• Organism: Homo sapiens (Human).
• Sequence Length: 331
• Subcellular Localization: Cytoplasm.
• Protein Description: Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen..
• Protein Sequence: MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRQLSRAR ------CCHHHHCCC	28.83	30622161
6	Phosphorylation	--MSRQLSRARPATV --CCHHHHCCCCHHH	18.63	12302123
12	Phosphorylation	LSRARPATVLGAMEM HHCCCCHHHHHHHHH	20.95	20068231
21	Methylation	LGAMEMGRRMDAPTS HHHHHHHCCCCCCHH	29.46	-
27	Phosphorylation	GRRMDAPTSAAVTRA HCCCCCCHHHHHHHH	32.49	20068231
28	Phosphorylation	RRMDAPTSAAVTRAF CCCCCCHHHHHHHHH	17.11	10953739
32	Phosphorylation	APTSAAVTRAFLERG CCHHHHHHHHHHHCC	16.14	20068231
85	Phosphorylation	AIPLFGNSLKPDSLR CCCCCCCCCCCCCHH	37.84	20068231
90	Phosphorylation	GNSLKPDSLRFQLET CCCCCCCCHHHHHHH	29.94	36013081
97	Phosphorylation	SLRFQLETSLKRLQC CHHHHHHHHHHHHCC	48.21	20068231
111	Phosphorylation	CPRVDLFYLHMPDHS CCCEEEEEEECCCCC	11.73	7479427
118	Phosphorylation	YLHMPDHSTPVEETL EEECCCCCCCHHHHH	41.61	113303451
143	Phosphorylation	KFVELGLSNYAAWEV CEEEECCCHHHHHHH	26.46	27251275
159	Phosphorylation	EICTLCKSNGWILPT HHHHHHHHCCCCCCC	39.31	25072903
166	Phosphorylation	SNGWILPTVYQGMYN HCCCCCCCHHHHHHH	28.53	25072903
168	Phosphorylation	GWILPTVYQGMYNAI CCCCCCHHHHHHHHH	11.22	25072903
172	Phosphorylation	PTVYQGMYNAITRQV CCHHHHHHHHHHHHH	14.31	25072903
176	Phosphorylation	QGMYNAITRQVETEL HHHHHHHHHHHHHHH	16.79	25072903
227	Phosphorylation	VGRFFGNTWAEMYRN CHHHHCHHHHHHHHH	26.82	28857561
256	Phosphorylation	EKALQAAYGASAPSM HHHHHHHHCCCCCCC	19.08	28857561
259	Phosphorylation	LQAAYGASAPSMTSA HHHHHCCCCCCCHHH	36.03	28857561
262	Phosphorylation	AYGASAPSMTSATLR HHCCCCCCCHHHHHH	34.12	27251275
264	Phosphorylation	GASAPSMTSATLRWM CCCCCCCHHHHHHHH	21.39	27251275
265	Phosphorylation	ASAPSMTSATLRWMY CCCCCCHHHHHHHHH	15.60	27251275
267	Phosphorylation	APSMTSATLRWMYHH CCCCHHHHHHHHHHH	19.34	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARK73_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARK73_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARK73_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARK73_HUMAN	AKR7A3	physical	16189514
ARK73_HUMAN	AKR7A3	physical	25416956
ARK72_HUMAN	AKR7A2	physical	26186194
COMD9_HUMAN	COMMD9	physical	26186194
GBB2_HUMAN	GNB2	physical	26186194
TRM11_HUMAN	TRMT11	physical	26186194
DDRGK_HUMAN	DDRGK1	physical	26186194
ARK72_HUMAN	AKR7A2	physical	28514442
COMD9_HUMAN	COMMD9	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442
GBB2_HUMAN	GNB2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.