DDRGK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDRGK_HUMAN
• UniProt AC: Q96HY6
• Protein Name: DDRGK domain-containing protein 1 {ECO:0000305}
• Gene Name: DDRGK1 {ECO:0000312|HGNC:HGNC:16110}
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Endoplasmic reticulum .
• Protein Description: Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. [PubMed: 25219498 May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B]
• Protein Sequence: MVAPVWYLVAAALLVGFILFLTRSRGRAASAGQEPLHNEELAGAGRVAQPGPLEPEEPRAGGRPRRRRDLGSRLQAQRRAQRVAWAEADENEEEAVILAQEEEGVEKPAETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTITGVIDDRGKFIYITPEELAAVANFIRQRGRVSIAELAQASNSLIAWGRESPAQAPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	VGFILFLTRSRGRAA HHHHHHHHHCCCCHH	21.18	-
30	Phosphorylation	RSRGRAASAGQEPLH HCCCCHHHCCCCCCC	31.76	29255136
72	Phosphorylation	RRRRDLGSRLQAQRR CCHHHHHHHHHHHHH	36.80	24670416
114	Phosphorylation	KPAETHLSGKIGAKK CCCHHHCCCCCCHHH	30.36	25849741
116	Malonylation	AETHLSGKIGAKKLR CHHHCCCCCCHHHHH	34.29	26320211
116	Ubiquitination	AETHLSGKIGAKKLR CHHHCCCCCCHHHHH	34.29	33845483
150	Phosphorylation	EERKRLESQREAEWK HHHHHHHHHHHHHHH	38.85	25159151
189	Phosphorylation	AQREHEEYLKLKEAF HHHHHHHHHHHHHHE	13.22	26552605
191	2-Hydroxyisobutyrylation	REHEEYLKLKEAFVV HHHHHHHHHHHHEEE	57.52	-
191	Ubiquitination	REHEEYLKLKEAFVV HHHHHHHHHHHHEEE	57.52	29967540
226	Phosphorylation	FINYIKQSKVVLLED HHHHHHHCCEEHHHH	23.55	21406692
227 (in isoform 2)	Ubiquitination	-	33.59	21890473
227	Ubiquitination	INYIKQSKVVLLEDL HHHHHHCCEEHHHHH	33.59	21890473
227 (in isoform 1)	Ubiquitination	-	33.59	21890473
227	Ubiquitination	INYIKQSKVVLLEDL HHHHHHCCEEHHHHH	33.59	29967540
236	Phosphorylation	VLLEDLASQVGLRTQ EHHHHHHHHHCCCCH	32.47	21406692
242	Phosphorylation	ASQVGLRTQDTINRI HHHHCCCCHHHHHHH	35.52	21406692
245	Phosphorylation	VGLRTQDTINRIQDL HCCCCHHHHHHHHHH	15.44	21406692
267	Ubiquitination	GVIDDRGKFIYITPE EEECCCCCEEEECHH	29.49	-
290	Phosphorylation	IRQRGRVSIAELAQA HHHCCCCCHHHHHHH	18.08	24719451
300	Phosphorylation	ELAQASNSLIAWGRE HHHHHCCCHHHCCCC	20.75	22199227
308	Phosphorylation	LIAWGRESPAQAPA- HHHCCCCCCCCCCC-	24.95	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDRGK_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
267	K	ubiquitylation	Ufmylated; conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1.	20018847

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDRGK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MSMO1_HUMAN	MSMO1	physical	22939629
IMPA3_HUMAN	IMPAD1	physical	22939629
MTEF3_HUMAN	MTERF3	physical	22939629
SYYM_HUMAN	YARS2	physical	22939629
SRPRA_HUMAN	SRPR	physical	26186194
MY18A_HUMAN	MYO18A	physical	26186194
PLSI_HUMAN	PLS1	physical	26186194
TRI26_HUMAN	TRIM26	physical	26186194
UFL1_HUMAN	UFL1	physical	26186194
CK5P3_HUMAN	CDK5RAP3	physical	26186194
RMND1_HUMAN	RMND1	physical	26186194
UFC1_HUMAN	UFC1	physical	26186194
D19L3_HUMAN	DPY19L3	physical	26186194
CK5P3_HUMAN	CDK5RAP3	physical	28514442
UFL1_HUMAN	UFL1	physical	28514442
TRI26_HUMAN	TRIM26	physical	28514442
D19L3_HUMAN	DPY19L3	physical	28514442
MY18A_HUMAN	MYO18A	physical	28514442
SRPRA_HUMAN	SRPR	physical	28514442
UFC1_HUMAN	UFC1	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.