RMND1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RMND1_HUMAN
• UniProt AC: Q9NWS8
• Protein Name: Required for meiotic nuclear division protein 1 homolog
• Gene Name: RMND1
• Organism: Homo sapiens (Human).
• Sequence Length: 449
• Subcellular Localization: Mitochondrion . May be localized in mitochondrial RNA granules (PubMed:25604853).
• Protein Description: Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome. [PubMed: 23022098]
• Protein Sequence: MPATLLRAVARSHHILSKAHQCRRIGHLMLKPLKEFENTTCSTLTIRQSLDLFLPDKTASGLNKSQILEMNQKKSDTSMLSPLNAARCQDEKAHLPTMKSFGTHRRVTHKPNLLGSKWFIKILKRHFSSVSTETFVPKQDFPQVKRPLKASRTRQPSRTNLPVLSVNEDLMHCTAFATADEYHLGNLSQDLASHGYVEVTSLPRDAANILVMGVENSAKEGDPGTIFFFREGAAVFWNVKDKTMKHVMKVLEKHEIQPYEIALVHWENEELNYIKIEGQSKLHRGEIKLNSELDLDDAILEKFAFSNALCLSVKLAIWEASLDKFIESIQSIPEALKAGKKVKLSHEEVMQKIGELFALRHRINLSSDFLITPDFYWDRENLEGLYDKTCQFLSIGRRVKVMNEKLQHCMELTDLMRNHLNEKRALRLEWMIVILITIEVMFELGRVFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	KSDTSMLSPLNAARC CCCCCCCCHHHHHHC	20.78	25849741
108	O-linked_Glycosylation	FGTHRRVTHKPNLLG HCCCCCCCCCCCCCC	23.52	30379171
151	Phosphorylation	VKRPLKASRTRQPSR CCCCCCCCCCCCCCC	32.37	24719451
243	Phosphorylation	FWNVKDKTMKHVMKV EEECCHHHHHHHHHH	41.40	24719451
249	Acetylation	KTMKHVMKVLEKHEI HHHHHHHHHHHHCCC	42.45	26822725
281	Ubiquitination	IKIEGQSKLHRGEIK EEEECCCCEECCCEE	40.19	-
281	2-Hydroxyisobutyrylation	IKIEGQSKLHRGEIK EEEECCCCEECCCEE	40.19	-
291	Phosphorylation	RGEIKLNSELDLDDA CCCEECCCCCCCCHH	50.39	-
337	Ubiquitination	QSIPEALKAGKKVKL HHHHHHHHCCCCCCC	63.24	-
394	Phosphorylation	DKTCQFLSIGRRVKV CCCCCHHHHHHHHHH	25.04	30257219
405	Ubiquitination	RVKVMNEKLQHCMEL HHHHHHHHHHHHHHH	48.74	-
413	Phosphorylation	LQHCMELTDLMRNHL HHHHHHHHHHHHHHC	17.49	29083192
423	Ubiquitination	MRNHLNEKRALRLEW HHHHCCHHHHHHHHH	41.73	-
423	2-Hydroxyisobutyrylation	MRNHLNEKRALRLEW HHHHCCHHHHHHHHH	41.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RMND1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RMND1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RMND1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FAM9B_HUMAN	FAM9B	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.