CK5P3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CK5P3_HUMAN
• UniProt AC: Q96JB5
• Protein Name: CDK5 regulatory subunit-associated protein 3 {ECO:0000312}
• Gene Name: CDK5RAP3 {ECO:0000312|HGNC:HGNC:18673}
• Organism: Homo sapiens (Human).
• Sequence Length: 506
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes and associates with microtubules.
• Protein Description: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. [PubMed: 12054757]
• Protein Sequence: MEDHQHVPIDIQTSKLLDWLVDRRHCSLKWQSLVLTIREKINAAIQDMPESEEIAQLLSGSYIHYFHCLRILDLLKGTEASTKNIFGRYSSQRMKDWQEIIALYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQEYSRKEEECQAGAAEMREQFYHSCKQYGITGENVRGELLALVKDLPSQLAEIGAAAQQSLGEAIDVYQASVGFVCESPTEQVLPMLRFVQKRGNSTVYEWRTGTEPSVVERPHLEELPEQVAEDAIDWGDFGVEAVSEGTDSGISAEAAGIDWGIFPESDSKDPGGDGIDWGDDAVALQITVLEAGTQAPEGVARGPDALTLLEYTETRNQFLDELMELEIFLAQRAVELSEEADVLSVSQFQLAPAILQGQTKEKMVTMVSVLEDLIGKLTSLQLQHLFMILASPRYVDRVTEFLQQKLKQSQLLALKKELMVQKQQEALEEQAALEPKLDLLLEKTKELQKLIEADISKRYSGRPVNLMGTSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Ubiquitination	DRRHCSLKWQSLVLT HCCCCCCCHHHHHHH	27.22	-
48	Ubiquitination	INAAIQDMPESEEIA HHHHHHCCCCHHHHH	1.96	29967540
73	Ubiquitination	FHCLRILDLLKGTEA HHHHHHHHHHCCCCC	47.81	23000965
76	Ubiquitination	LRILDLLKGTEASTK HHHHHHHCCCCCCCC	71.70	33845483
78	Phosphorylation	ILDLLKGTEASTKNI HHHHHCCCCCCCCCC	27.13	30576142
79	Neddylation	LDLLKGTEASTKNIF HHHHCCCCCCCCCCC	49.65	32015554
79	Ubiquitination	LDLLKGTEASTKNIF HHHHCCCCCCCCCCC	49.65	23000965
79 (in isoform 2)	Ubiquitination	-	49.65	21890473
81	Phosphorylation	LLKGTEASTKNIFGR HHCCCCCCCCCCCCC	33.41	24719451
82	Phosphorylation	LKGTEASTKNIFGRY HCCCCCCCCCCCCCC	34.85	24719451
83	Ubiquitination	KGTEASTKNIFGRYS CCCCCCCCCCCCCCC	45.62	27667366
101	Ubiquitination	MKDWQEIIALYEKDN CCCHHHHHHHHHCCC	1.81	33845483
104	Phosphorylation	WQEIIALYEKDNTYL HHHHHHHHHCCCEEE	16.35	-
108	Ubiquitination	IALYEKDNTYLVELS HHHHHCCCEEEEEHH	41.51	-
108	Ubiquitination	IALYEKDNTYLVELS HHHHHCCCEEEEEHH	41.51	33845483
109	Phosphorylation	ALYEKDNTYLVELSS HHHHCCCEEEEEHHH	28.50	20068231
110	Phosphorylation	LYEKDNTYLVELSSL HHHCCCEEEEEHHHH	18.27	20068231
115	Phosphorylation	NTYLVELSSLLVRNV CEEEEEHHHHHHHHC	12.87	20068231
116	Phosphorylation	TYLVELSSLLVRNVN EEEEEHHHHHHHHCC	38.04	20068231
124	Phosphorylation	LLVRNVNYEIPSLKK HHHHHCCCCCCCHHH	15.79	28152594
128	Phosphorylation	NVNYEIPSLKKQIAK HCCCCCCCHHHHHHH	59.49	24719451
130	2-Hydroxyisobutyrylation	NYEIPSLKKQIAKCQ CCCCCCHHHHHHHHH	47.14	-
135	Ubiquitination	SLKKQIAKCQQLQQE CHHHHHHHHHHHHHH	33.92	29967540
143	Phosphorylation	CQQLQQEYSRKEEEC HHHHHHHHHHCHHHH	14.94	20860994
144	Phosphorylation	QQLQQEYSRKEEECQ HHHHHHHHHCHHHHH	35.80	20860994
146	Acetylation	LQQEYSRKEEECQAG HHHHHHHCHHHHHHH	64.63	26051181
146	Ubiquitination	LQQEYSRKEEECQAG HHHHHHHCHHHHHHH	64.63	-
156	Ubiquitination	ECQAGAAEMREQFYH HHHHHHHHHHHHHHH	37.93	-
160	Ubiquitination	GAAEMREQFYHSCKQ HHHHHHHHHHHHHHH	33.56	-
160	Ubiquitination	GAAEMREQFYHSCKQ HHHHHHHHHHHHHHH	33.56	29967540
162	Phosphorylation	AEMREQFYHSCKQYG HHHHHHHHHHHHHHC	7.78	28152594
164	Phosphorylation	MREQFYHSCKQYGIT HHHHHHHHHHHHCCC	16.19	28152594
166	Acetylation	EQFYHSCKQYGITGE HHHHHHHHHHCCCCC	49.96	26051181
166	Malonylation	EQFYHSCKQYGITGE HHHHHHHHHHCCCCC	49.96	32601280
166	Neddylation	EQFYHSCKQYGITGE HHHHHHHHHHCCCCC	49.96	32015554
166	Ubiquitination	EQFYHSCKQYGITGE HHHHHHHHHHCCCCC	49.96	23000965
170	Ubiquitination	HSCKQYGITGENVRG HHHHHHCCCCCCHHH	3.68	33845483
170 (in isoform 3)	Ubiquitination	-	3.68	21906983
171	Ubiquitination	SCKQYGITGENVRGE HHHHHCCCCCCHHHH	33.80	-
172	Ubiquitination	CKQYGITGENVRGEL HHHHCCCCCCHHHHH	23.66	23503661
191	Ubiquitination	KDLPSQLAEIGAAAQ HCHHHHHHHHHHHHH	9.95	21890473
191	Ubiquitination	KDLPSQLAEIGAAAQ HCHHHHHHHHHHHHH	9.95	-
191	Neddylation	KDLPSQLAEIGAAAQ HCHHHHHHHHHHHHH	9.95	32015554
191	Ubiquitination	KDLPSQLAEIGAAAQ HCHHHHHHHHHHHHH	9.95	23000965
191 (in isoform 1)	Ubiquitination	-	9.95	21890473
217	Ubiquitination	ASVGFVCESPTEQVL CCCCEEECCCHHHHH	55.22	33845483
225	Ubiquitination	SPTEQVLPMLRFVQK CCHHHHHHHHHHHHH	22.39	29967540
226	Ubiquitination	PTEQVLPMLRFVQKR CHHHHHHHHHHHHHH	3.52	23503661
232	Ubiquitination	PMLRFVQKRGNSTVY HHHHHHHHHCCCCEE	57.90	23503661
233	Methylation	MLRFVQKRGNSTVYE HHHHHHHHCCCCEEE	32.22	-
239	Phosphorylation	KRGNSTVYEWRTGTE HHCCCCEEEECCCCC	15.17	-
243	Phosphorylation	STVYEWRTGTEPSVV CCEEEECCCCCCCCC	49.91	20068231
245	Phosphorylation	VYEWRTGTEPSVVER EEEECCCCCCCCCCC	44.07	20068231
246	Ubiquitination	YEWRTGTEPSVVERP EEECCCCCCCCCCCC	36.60	29967540
248	Phosphorylation	WRTGTEPSVVERPHL ECCCCCCCCCCCCCH	32.34	20068231
253	Ubiquitination	EPSVVERPHLEELPE CCCCCCCCCHHHCCH	23.94	33845483
253 (in isoform 3)	Ubiquitination	-	23.94	21906983
259	Ubiquitination	RPHLEELPEQVAEDA CCCHHHCCHHHHHHC	33.00	29967540
267	Ubiquitination	EQVAEDAIDWGDFGV HHHHHHCCCCCCCCE	7.66	32015554
302	Ubiquitination	GIFPESDSKDPGGDG CCCCCCCCCCCCCCC	48.51	23503661
304	Ubiquitination	FPESDSKDPGGDGID CCCCCCCCCCCCCCC	51.53	23503661
308	Ubiquitination	DSKDPGGDGIDWGDD CCCCCCCCCCCCCHH	57.71	33845483
308 (in isoform 2)	Ubiquitination	-	57.71	21890473
310	Ubiquitination	KDPGGDGIDWGDDAV CCCCCCCCCCCHHHE	4.85	23503661
342	Phosphorylation	ARGPDALTLLEYTET HCCCCHHHHHHCHHH	30.90	24043423
346	Phosphorylation	DALTLLEYTETRNQF CHHHHHHCHHHHHHH	15.17	24043423
347	Phosphorylation	ALTLLEYTETRNQFL HHHHHHCHHHHHHHH	22.85	24043423
349	Phosphorylation	TLLEYTETRNQFLDE HHHHCHHHHHHHHHH	27.41	24043423
355	Ubiquitination	ETRNQFLDELMELEI HHHHHHHHHHHHHHH	48.55	33845483
358	Ubiquitination	NQFLDELMELEIFLA HHHHHHHHHHHHHHH	5.34	23503661
363	Ubiquitination	ELMELEIFLAQRAVE HHHHHHHHHHHHHHH	3.18	29967540
364	Ubiquitination	LMELEIFLAQRAVEL HHHHHHHHHHHHHHH	4.95	23503661
370	Ubiquitination	FLAQRAVELSEEADV HHHHHHHHHHHHCCE	45.66	23503661
370 (in isoform 2)	Ubiquitination	-	45.66	-
372	Phosphorylation	AQRAVELSEEADVLS HHHHHHHHHHCCEEE	21.64	-
384	Ubiquitination	VLSVSQFQLAPAILQ EEEHHHHHHHHHHHC	29.13	29967540
391	Ubiquitination	QLAPAILQGQTKEKM HHHHHHHCCCCHHHH	35.52	33845483
391 (in isoform 2)	Ubiquitination	-	35.52	21890473
394	Phosphorylation	PAILQGQTKEKMVTM HHHHCCCCHHHHHHH	48.25	-
395	Ubiquitination	AILQGQTKEKMVTMV HHHCCCCHHHHHHHH	47.66	21906983
397	Ubiquitination	LQGQTKEKMVTMVSV HCCCCHHHHHHHHHH	39.98	23503661
400	Phosphorylation	QTKEKMVTMVSVLED CCHHHHHHHHHHHHH	14.35	22210691
403	Phosphorylation	EKMVTMVSVLEDLIG HHHHHHHHHHHHHHH	15.34	30631047
405	Ubiquitination	MVTMVSVLEDLIGKL HHHHHHHHHHHHHHH	3.10	32015554
420	Ubiquitination	TSLQLQHLFMILASP HHHHHHHHHHHHHCH	1.69	-
420	Ubiquitination	TSLQLQHLFMILASP HHHHHHHHHHHHHCH	1.69	33845483
420 (in isoform 1)	Ubiquitination	-	1.69	21890473
422	Ubiquitination	LQLQHLFMILASPRY HHHHHHHHHHHCHHH	2.86	23503661
440	Ubiquitination	VTEFLQQKLKQSQLL HHHHHHHHHHHHHHH	44.70	-
442	Ubiquitination	EFLQQKLKQSQLLAL HHHHHHHHHHHHHHH	55.74	33845483
450	Sumoylation	QSQLLALKKELMVQK HHHHHHHHHHHHHHH	38.30	-
450	Sumoylation	QSQLLALKKELMVQK HHHHHHHHHHHHHHH	38.30	25772364
450	Ubiquitination	QSQLLALKKELMVQK HHHHHHHHHHHHHHH	38.30	29967540
451	Ubiquitination	SQLLALKKELMVQKQ HHHHHHHHHHHHHHH	57.86	23503661
457	Ubiquitination	KKELMVQKQQEALEE HHHHHHHHHHHHHHH	42.40	23503661
465	Ubiquitination	QQEALEEQAALEPKL HHHHHHHHHHHHHHH	23.66	-
467	Ubiquitination	EALEEQAALEPKLDL HHHHHHHHHHHHHHH	16.50	-
467	Ubiquitination	EALEEQAALEPKLDL HHHHHHHHHHHHHHH	16.50	33845483
471	Ubiquitination	EQAALEPKLDLLLEK HHHHHHHHHHHHHHH	45.30	29967540
475	Ubiquitination	LEPKLDLLLEKTKEL HHHHHHHHHHHHHHH	6.07	29967540
476	Ubiquitination	EPKLDLLLEKTKELQ HHHHHHHHHHHHHHH	9.13	-
476	Ubiquitination	EPKLDLLLEKTKELQ HHHHHHHHHHHHHHH	9.13	23503661
478	2-Hydroxyisobutyrylation	KLDLLLEKTKELQKL HHHHHHHHHHHHHHH	65.94	-
478	Ubiquitination	KLDLLLEKTKELQKL HHHHHHHHHHHHHHH	65.94	33845483
482	Ubiquitination	LLEKTKELQKLIEAD HHHHHHHHHHHHHHH	6.08	-
482	Ubiquitination	LLEKTKELQKLIEAD HHHHHHHHHHHHHHH	6.08	23503661
484	Ubiquitination	EKTKELQKLIEADIS HHHHHHHHHHHHHHH	65.15	29967540
492	2-Hydroxyisobutyrylation	LIEADISKRYSGRPV HHHHHHHHHCCCCCC	56.54	-
492	Ubiquitination	LIEADISKRYSGRPV HHHHHHHHHCCCCCC	56.54	32015554
494	Phosphorylation	EADISKRYSGRPVNL HHHHHHHCCCCCCCC	21.15	22461510
496	Ubiquitination	DISKRYSGRPVNLMG HHHHHCCCCCCCCCC	29.04	-
496	Ubiquitination	DISKRYSGRPVNLMG HHHHHCCCCCCCCCC	29.04	29967540
503	Ubiquitination	GRPVNLMGTSL---- CCCCCCCCCCC----	18.47	-
503	Ubiquitination	GRPVNLMGTSL---- CCCCCCCCCCC----	18.47	33845483
504	Phosphorylation	RPVNLMGTSL----- CCCCCCCCCC-----	16.94	26471730
505	Phosphorylation	PVNLMGTSL------ CCCCCCCCC------	26.76	25850435
509	Ubiquitination	MGTSL---------- CCCCC----------		29967540
517	Ubiquitination	------------------ ------------------		-
517	Ubiquitination	------------------ ------------------		32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CK5P3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CK5P3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CK5P3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UFM1_HUMAN	UFM1	physical	17353931
UFC1_HUMAN	UFC1	physical	17353931
DDRGK_HUMAN	DDRGK1	physical	17353931
UFL1_HUMAN	UFL1	physical	17353931
ARL1_HUMAN	ARL1	physical	17353931
DPYL1_HUMAN	CRMP1	physical	16169070
CD5R1_HUMAN	CDK5R1	physical	10915792
UFL1_HUMAN	UFL1	physical	20164180
LPD6B_HUMAN	LYPD6B	physical	20164180
HSP74_HUMAN	HSPA4	physical	20164180
UBC_HUMAN	UBC	physical	20164180
UFC1_HUMAN	UFC1	physical	20164180
HSP7C_HUMAN	HSPA8	physical	20164180
HUWE1_HUMAN	HUWE1	physical	20164180
RL10A_HUMAN	RPL10A	physical	20164180
PP4P2_HUMAN	TMEM55A	physical	20164180
NPM_HUMAN	NPM1	physical	20164180
RS3_HUMAN	RPS3	physical	20164180
CADH4_HUMAN	CDH4	physical	20228063
DDRGK_HUMAN	DDRGK1	physical	20228063
HSP74_HUMAN	HSPA4	physical	20228063
CDN2A_HUMAN	CDKN2A	physical	16173922
ARF_HUMAN	CDKN2A	physical	16173922
MDM2_HUMAN	MDM2	physical	16173922
CDN2A_HUMAN	CDKN2A	physical	23028987
ARF_HUMAN	CDKN2A	physical	23028987
TBG1_HUMAN	TUBG1	physical	21465471
TAB1_HUMAN	TAB1	physical	21988832
IMA1_HUMAN	KPNA2	physical	21988832
DGC14_HUMAN	DGCR14	physical	21988832
UFL1_HUMAN	UFL1	physical	28514442
TMED4_HUMAN	TMED4	physical	28514442
PLD2_HUMAN	PLD2	physical	28514442
TMED1_HUMAN	TMED1	physical	28514442
TMED9_HUMAN	TMED9	physical	28514442
PP4P2_HUMAN	TMEM55A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.