ARL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARL1_HUMAN
• UniProt AC: P40616
• Protein Name: ADP-ribosylation factor-like protein 1
• Gene Name: ARL1
• Organism: Homo sapiens (Human).
• Sequence Length: 181
• Subcellular Localization: Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Membrane ; Lipid-anchor .
• Protein Description: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus..
• Protein Sequence: MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEELRKAILVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVETLKSRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGGFFSSIF ------CCCHHHHHH	41.43	25255805
6	Phosphorylation	--MGGFFSSIFSSLF --CCCHHHHHHHHHH	21.91	24043423
7	Phosphorylation	-MGGFFSSIFSSLFG -CCCHHHHHHHHHHC	23.61	24043423
10	Phosphorylation	GFFSSIFSSLFGTRE CHHHHHHHHHHCCCC	25.18	24043423
11	Phosphorylation	FFSSIFSSLFGTREM HHHHHHHHHHCCCCE	19.57	24043423
15	Phosphorylation	IFSSLFGTREMRILI HHHHHHCCCCEEEEE	19.00	24043423
44	Phosphorylation	LQVGEVVTTIPTIGF EECCCEEEECCCCCE	24.96	-
45	O-linked_Glycosylation	QVGEVVTTIPTIGFN ECCCEEEECCCCCEE	17.22	OGP
45	Ubiquitination	QVGEVVTTIPTIGFN ECCCEEEECCCCCEE	17.22	-
48	O-linked_Glycosylation	EVVTTIPTIGFNVET CEEEECCCCCEEEEE	29.86	OGP
58	Phosphorylation	FNVETVTYKNLKFQV EEEEEEEEECCEEEE	8.11	-
59	Ubiquitination	NVETVTYKNLKFQVW EEEEEEEECCEEEEE	46.57	-
62	Ubiquitination	TVTYKNLKFQVWDLG EEEEECCEEEEEECC	43.05	21890473
62	Ubiquitination	TVTYKNLKFQVWDLG EEEEECCEEEEEECC	43.05	21890473
62	Ubiquitination	TVTYKNLKFQVWDLG EEEEECCEEEEEECC	43.05	21890473
72	Phosphorylation	VWDLGGQTSIRPYWR EEECCCCCCCCCEEE	29.42	27251275
73	Phosphorylation	WDLGGQTSIRPYWRC EECCCCCCCCCEEEE	14.54	27251275
87	Ubiquitination	CYYSNTDAVIYVVDS EEECCCCEEEEEEEC	6.38	-
104	Ubiquitination	RDRIGISKSELVAML CCCCCCCHHHHHHHH	46.13	21890473
110	Sulfoxidation	SKSELVAMLEEEELR CHHHHHHHHCHHHHH	3.64	30846556
135	Ubiquitination	QDMEQAMTSSEMANS HHHHHHHCHHHHHHH	31.92	-
140	Ubiquitination	AMTSSEMANSLGLPA HHCHHHHHHHCCCHH	9.82	-
145	Ubiquitination	EMANSLGLPALKDRK HHHHHCCCHHHCCCC	2.45	-
149	Ubiquitination	SLGLPALKDRKWQIF HCCCHHHCCCCEEEE	58.56	-
152	Ubiquitination	LPALKDRKWQIFKTS CHHHCCCCEEEEECC	54.29	-
157	Ubiquitination	DRKWQIFKTSATKGT CCCEEEEECCCCCCC	43.10	21890473
157	Acetylation	DRKWQIFKTSATKGT CCCEEEEECCCCCCC	43.10	25953088
157	Ubiquitination	DRKWQIFKTSATKGT CCCEEEEECCCCCCC	43.10	21890473
157	Ubiquitination	DRKWQIFKTSATKGT CCCEEEEECCCCCCC	43.10	21890473
162	Ubiquitination	IFKTSATKGTGLDEA EEECCCCCCCCHHHH	54.94	-
178	Ubiquitination	EWLVETLKSRQ---- HHHHHHHHHCC----	51.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GOGA1_HUMAN	GOLGA1	physical	12972563
GCC1_HUMAN	GCC1	physical	12972563
GCC2_HUMAN	GCC2	physical	12972563
ARFP2_HUMAN	ARFIP2	physical	12972563
GOGA4_HUMAN	GOLGA4	physical	12972563
ARFP2_HUMAN	ARFIP2	physical	11792819

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.