CADH4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CADH4_HUMAN
• UniProt AC: P55283
• Protein Name: Cadherin-4
• Gene Name: CDH4
• Organism: Homo sapiens (Human).
• Sequence Length: 916
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development..
• Protein Sequence: MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTAGAGVLL ------CCCHHHHHH	33.52	24043423
13	Phosphorylation	GVLLLLLSLSGALRA HHHHHHHHHHHHHHH	22.06	22817900
15	Phosphorylation	LLLLLSLSGALRAHN HHHHHHHHHHHHHCC	20.74	22817900
60	Phosphorylation	KLLQVKFSSCVGTKG CEEEEEEHHCCCCCC	19.67	-
65	Phosphorylation	KFSSCVGTKGTQYET EEHHCCCCCCCEEEE	13.10	-
66	Ubiquitination	FSSCVGTKGTQYETN EHHCCCCCCCEEEEC	54.77	-
84	O-linked_Glycosylation	FKVGADGTVFATREL EEECCCCCEEEEEEE	17.01	55828177
88	O-linked_Glycosylation	ADGTVFATRELQVPS CCCCEEEEEEEECCC	17.14	55828183
132	Ubiquitination	SSPHSGHKPQKGKKV CCCCCCCCCCCCCEE	53.31	-
145	Phosphorylation	KVVALDPSPPPKDTL EEEECCCCCCCCCCC	50.10	24719451
149	Ubiquitination	LDPSPPPKDTLLPWP CCCCCCCCCCCCCCC	69.94	-
205	Phosphorylation	DNDIPIRYSITGVGA CCCCCEEEEEECCCC	12.73	-
230	Phosphorylation	DSMSGRMYVTRPMDR ECCCCCEEEECCCCH	9.41	-
264	Phosphorylation	VENPIDLYIYVIDMN CCCCCEEEEEEEECC	6.10	22817900
266	Phosphorylation	NPIDLYIYVIDMNDN CCCEEEEEEEECCCC	4.27	22817900
283	N-linked_Glycosylation	EFINQVYNGSVDEGS HHHHHHHCCCCCCCC	37.09	UniProtKB CARBOHYD
320	Phosphorylation	MVRYRIVTQTPQSPS EEEEEEEECCCCCCC	25.10	24275569
325	Phosphorylation	IVTQTPQSPSQNMFT EEECCCCCCCCCCEE	27.94	24275569
327	Phosphorylation	TQTPQSPSQNMFTIN ECCCCCCCCCCEEEE	39.16	24275569
332	Phosphorylation	SPSQNMFTINSETGD CCCCCCEEEECCCCC	14.42	24275569
335	Phosphorylation	QNMFTINSETGDIVT CCCEEEECCCCCEEE	32.46	24275569
337	Phosphorylation	MFTINSETGDIVTVA CEEEECCCCCEEEEE	39.72	24275569
342	Phosphorylation	SETGDIVTVAAGLDR CCCCCEEEEEECCCH	12.54	24275569
405	Methylation	AGEVPENRVETVVAN CCCCCCCCEEEEEEE	26.45	-
412	N-linked_Glycosylation	RVETVVANLTVMDRD CEEEEEEEEEEECCC	25.32	UniProtKB CARBOHYD
475	Phosphorylation	FMLTVMVSNQAPLAS EEEEEEECCCCCCCC	12.72	22210691
490	Phosphorylation	GIQMSFQSTAGVTIS CCEEEEECCCCEEEE	20.43	22210691
495	O-linked_Glycosylation	FQSTAGVTISIMDIN EECCCCEEEEEEECC	14.21	OGP
497	O-linked_Glycosylation	STAGVTISIMDINEA CCCCEEEEEEECCCC	11.51	OGP
546	Ubiquitination	QQAVRYSKLSDPASW HHHHHHHHCCCCCCE	42.97	-
557	N-linked_Glycosylation	PASWLHINATNGQIT CCCEEEEECCCCCEE	29.93	UniProtKB CARBOHYD
632	N-linked_Glycosylation	KPNLNAINITAADAD CCCCCEEEEEEECCC	24.13	UniProtKB CARBOHYD
660	Ubiquitination	FVPAAVRKNWTITRL CCCHHHHCCCEEEEE	50.68	-
661	N-linked_Glycosylation	VPAAVRKNWTITRLN CCHHHHCCCEEEEEC	30.47	UniProtKB CARBOHYD
675	Phosphorylation	NGDYAQLSLRILYLE CCCHHHEEHHHHHHH	11.97	24719451
702	N-linked_Glycosylation	SGNPPLSNTSIIKVK CCCCCCCCCEEEEEE	45.59	UniProtKB CARBOHYD
704	Phosphorylation	NPPLSNTSIIKVKVC CCCCCCCEEEEEEEE	26.94	24719451
708	Ubiquitination	SNTSIIKVKVCPCDD CCCEEEEEEEEECCC	3.86	23503661
745	Ubiquitination	ILICILILLTMVLLF HHHHHHHHHHHHHHH	2.67	23503661
782	Ubiquitination	DVRDNILKYDEEGGG HHHHHCCCCCCCCCC	47.02	23503661
783	Phosphorylation	VRDNILKYDEEGGGE HHHHCCCCCCCCCCC	25.74	28796482
795	Phosphorylation	GGEEDQDYDLSQLQQ CCCCCCCCCHHHHCC	17.10	28796482
798	Phosphorylation	EDQDYDLSQLQQPEA CCCCCCHHHHCCCHH	26.41	28796482
811	Phosphorylation	EAMGHVPSKAPGVRR HHHCCCCCCCCCCEE	40.12	-
862	Phosphorylation	NDPTAPPYDSLLVFD CCCCCCCCCEEEEEE	19.66	16371504
870	Phosphorylation	DSLLVFDYEGSGSTA CEEEEEEECCCCCCC	15.66	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CADH4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CADH4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CADH4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CADH2_HUMAN	CDH2	physical	10662782

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.