PLD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLD2_HUMAN
• UniProt AC: O14939
• Protein Name: Phospholipase D2
• Gene Name: PLD2
• Organism: Homo sapiens (Human).
• Sequence Length: 933
• Subcellular Localization: Membrane; Peripheral membrane protein.
• Protein Description: May have a role in signal-induced cytoskeletal regulation and/or endocytosis..
• Protein Sequence: MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTATPESLF ------CCCCHHHHC	38.96	30576142
29	Phosphorylation	MESDEVDTLKEGEDP CCCCCCCHHHCCCCH	44.92	30576142
72	Phosphorylation	VTAQVVGTERYTSGS EEEEEECCEEECCCC	12.99	22817900
75	Phosphorylation	QVVGTERYTSGSKVG EEECCEEECCCCEEE	10.06	23312004
76	Phosphorylation	VVGTERYTSGSKVGT EECCEEECCCCEEEE	32.60	30108239
77	Phosphorylation	VGTERYTSGSKVGTC ECCEEECCCCEEEEE	31.94	28152594
79	Phosphorylation	TERYTSGSKVGTCTL CEEECCCCEEEEEEE	24.76	28152594
80	Ubiquitination	ERYTSGSKVGTCTLY EEECCCCEEEEEEEE	48.48	23000965
83	Phosphorylation	TSGSKVGTCTLYSVR CCCCEEEEEEEEEEE	12.81	30108239
85	Phosphorylation	GSKVGTCTLYSVRLT CCEEEEEEEEEEEEC	28.68	23312004
99	Phosphorylation	THGDFSWTTKKKYRH CCCCCCCCCHHHHHH	27.78	22817900
100	Phosphorylation	HGDFSWTTKKKYRHF CCCCCCCCHHHHHHH	34.31	22817900
118	Ubiquitination	HRDLLRHKVLMSLLP HHHHHHHHHHHHHHH	30.54	23000965
133	Phosphorylation	LARFAVAYSPARDAG HHHHHHHHCCCCCCC	14.48	24117733
134	Phosphorylation	ARFAVAYSPARDAGN HHHHHHHCCCCCCCC	11.44	21712546
146	Phosphorylation	AGNREMPSLPRAGPE CCCCCCCCCCCCCCC	50.09	30266825
155	Phosphorylation	PRAGPEGSTRHAASK CCCCCCCHHHHHHHH	22.17	26699800
156	Phosphorylation	RAGPEGSTRHAASKQ CCCCCCHHHHHHHHH	37.01	26699800
161	Phosphorylation	GSTRHAASKQKYLEN CHHHHHHHHHHHHHH	36.08	-
169	Phosphorylation	KQKYLENYLNRLLTM HHHHHHHHHHHHHHH	8.93	22817900
175	Phosphorylation	NYLNRLLTMSFYRNY HHHHHHHHHHHHCCH	18.50	18006275
179	Phosphorylation	RLLTMSFYRNYHAMT HHHHHHHHCCHHHHH	7.22	18006275
213	Phosphorylation	EGMIRKRSGGHRVPG HHHCCCCCCCCCCCC	52.76	-
223	S-palmitoylation	HRVPGLTCCGRDQVC CCCCCEEECCCCCEE	2.52	29575903
224	S-palmitoylation	RVPGLTCCGRDQVCY CCCCEEECCCCCEEH	4.17	29575903
243	Phosphorylation	RWLVVKDSFLLYMCL CEEEECCHHHHHHHH	16.45	22817900
252	Phosphorylation	LLYMCLETGAISFVQ HHHHHHHHCCEEEEE	20.97	22817900
271	Ubiquitination	GFEVQVGKRSTEARH CCEEEECCCCCCHHC	44.30	23000965
274	Phosphorylation	VQVGKRSTEARHGVR EEECCCCCCHHCCCE	37.38	22210691
292	Ubiquitination	SHRSLILKCSSYRQA CCCEEEECCHHHHHH	25.69	-
292	Methylation	SHRSLILKCSSYRQA CCCEEEECCHHHHHH	25.69	115975121
292	Ubiquitination	SHRSLILKCSSYRQA CCCEEEECCHHHHHH	25.69	21963094
296	Phosphorylation	LILKCSSYRQARWWA EEECCHHHHHHHHHH	7.17	20176813
388	Methylation	WRLDIMLKRKAEEGV CCHHHHHHHHHHCCC	34.18	42363113
388	Ubiquitination	WRLDIMLKRKAEEGV CCHHHHHHHHHHCCC	34.18	22817900
388	Ubiquitination	WRLDIMLKRKAEEGV CCHHHHHHHHHHCCC	34.18	21906983
388 (in isoform 1)	Ubiquitination	-	34.18	21906983
390	Ubiquitination	LDIMLKRKAEEGVRV HHHHHHHHHHCCCEE	59.57	22817900
415	Phosphorylation	ALGINSGYSKRALML HHCCCCCCCHHHHHH	15.73	20176813
416	Phosphorylation	LGINSGYSKRALMLL HCCCCCCCHHHHHHH	21.13	-
473	Phosphorylation	DDLHYRLTDLGDSSE CHHHEEECCCCCCCC	21.85	23312004
478	Phosphorylation	RLTDLGDSSESAASQ EECCCCCCCCCHHCC	33.92	23312004
479	Phosphorylation	LTDLGDSSESAASQP ECCCCCCCCCHHCCC	40.07	23312004
481	Phosphorylation	DLGDSSESAASQPPT CCCCCCCCHHCCCCC	30.96	23312004
484	Phosphorylation	DSSESAASQPPTPRP CCCCCHHCCCCCCCC	42.83	23312004
488	Phosphorylation	SAASQPPTPRPDSPA CHHCCCCCCCCCCCC	38.32	26657352
493	Phosphorylation	PPTPRPDSPATPDLS CCCCCCCCCCCCCCC	21.08	27050516
496	Phosphorylation	PRPDSPATPDLSHNQ CCCCCCCCCCCCCCC	22.25	23312004
500	Phosphorylation	SPATPDLSHNQFFWL CCCCCCCCCCCEEEC	27.98	23312004
511	Phosphorylation	FFWLGKDYSNLITKD EEECCCCHHHCCCCC	11.71	20176813
517	Ubiquitination	DYSNLITKDWVQLDR CHHHCCCCCCCCCCC	42.47	-
566	Phosphorylation	FIQRWNFTKTTKAKY HHHHCCCCCCCCCCC	25.03	20733000
573	Phosphorylation	TKTTKAKYKTPTYPY CCCCCCCCCCCCCCE	25.59	26657352
575	Phosphorylation	TTKAKYKTPTYPYLL CCCCCCCCCCCCEEC	20.13	26657352
577	Phosphorylation	KAKYKTPTYPYLLPK CCCCCCCCCCEECCC	42.22	28152594
578	Phosphorylation	AKYKTPTYPYLLPKS CCCCCCCCCEECCCC	7.35	26657352
580	Phosphorylation	YKTPTYPYLLPKSTS CCCCCCCEECCCCCC	15.51	-
609	Phosphorylation	TTVQVLRSVDRWSAG EEEEEEECCCCCCCC	24.98	24719451
656	Ubiquitination	DGRTVLNKVGDEIVD CCCCHHHHHHHHHHH	43.35	23000965
656	Ubiquitination	DGRTVLNKVGDEIVD CCCCHHHHHHHHHHH	43.35	21906983
656 (in isoform 1)	Ubiquitination	-	43.35	21906983
766	Phosphorylation	VLIADDRTVIIGSAN EEECCCCEEEEEECC	24.05	22210691
771	Phosphorylation	DRTVIIGSANINDRS CCEEEEEECCCCCHH	14.03	22210691
814	Phosphorylation	QAGRFALSLRKHCFG HHHHHHHHHHHHHHE	23.77	24719451
886	Phosphorylation	VAVEPLATVSPPLAR HHCCCCCCCCCCCHH	29.24	28348404
888	Phosphorylation	VEPLATVSPPLARSE CCCCCCCCCCCHHHH	19.22	21815630
922	Phosphorylation	SLLPPLGSKEGMIPL CCCCCCCCCCCCEEE	34.91	24945436

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
134	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
175	T	Phosphorylation	Kinase	AKT1	P31749	PSP
179	Y	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
243	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
252	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
296	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
415	Y	Phosphorylation	Kinase	JAK3	P52333	PSP
511	Y	Phosphorylation	Kinase	SRC	P12931	PSP
566	T	Phosphorylation	Kinase	PRKCD	Q05655	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAV1_HUMAN	CAV1	physical	14675200
AQP3_HUMAN	AQP3	physical	14675200
G3P_HUMAN	GAPDH	physical	12753082
SRC_HUMAN	SRC	physical	12697812
PLCG1_HUMAN	PLCG1	physical	12646582
ARF1_HUMAN	ARF1	physical	11373276
ACTB_RAT	Actb	physical	11373276
ARF1_HUMAN	ARF1	physical	10801846
KPCA_HUMAN	PRKCA	physical	11042115
AMPH_HUMAN	AMPH	genetic	10764771
BIN1_HUMAN	BIN1	genetic	10764771
AMPH_HUMAN	AMPH	physical	10764771
PEA15_HUMAN	PEA15	physical	10926929
CAV1_HUMAN	CAV1	physical	10675563
CAV2_HUMAN	CAV2	physical	10675563
ALDOA_HUMAN	ALDOA	physical	11876650
KPCD_HUMAN	PRKCD	physical	11744693
HIF1A_HUMAN	HIF1A	physical	26611735
EGLN1_HUMAN	EGLN1	physical	26611735
VHL_HUMAN	VHL	physical	26611735

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00122: Choline