AQP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AQP3_HUMAN
• UniProt AC: Q92482
• Protein Name: Aquaporin-3
• Gene Name: AQP3
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Subcellular Localization: Basolateral cell membrane; Multi-pass membrane protein. In collecting ducts of kidney.
• Protein Description: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity)..
• Protein Sequence: MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MGRQKELVSRCG ---CCHHHHHHHHHH	52.21	-
9	Phosphorylation	GRQKELVSRCGEMLH CHHHHHHHHHHHHHH	34.18	22673903
100	Sumoylation	LAREPWIKLPIYTLA HHCCCCCCCCHHHHH	44.32	-
141	N-linked_Glycosylation	QLFVSGPNGTAGIFA CEEEECCCCCCEEEE	65.06	UniProtKB CARBOHYD
287	Ubiquitination	NVKLAHVKHKEQI-- CCEEEECCCHHCC--	38.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AQP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AQP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AQP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLD2_HUMAN	PLD2	physical	14675200
CAV1_HUMAN	CAV1	physical	14675200

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.