PP4P2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PP4P2_HUMAN
• UniProt AC: Q8N4L2
• Protein Name: Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
• Gene Name: PIP4P2 {ECO:0000312|HGNC:HGNC:25452}
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate..
• Protein Sequence: MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHSFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ADGVDERSPLLSASH CCCCCCCCCCCCCCC		30631047
14	Phosphorylation	DERSPLLSASHSGNV CCCCCCCCCCCCCCC		30631047
16	Phosphorylation	RSPLLSASHSGNVTP CCCCCCCCCCCCCCC		30631047
18	Phosphorylation	PLLSASHSGNVTPTA CCCCCCCCCCCCCCC		22617229
22	Phosphorylation	ASHSGNVTPTAPPYL CCCCCCCCCCCCCCC		25159151
24	Phosphorylation	HSGNVTPTAPPYLQE CCCCCCCCCCCCCCC		22115753
28	Phosphorylation	VTPTAPPYLQESSPR CCCCCCCCCCCCCCC		28122231
32	Phosphorylation	APPYLQESSPRAELP CCCCCCCCCCCCCCC		25159151
33	Phosphorylation	PPYLQESSPRAELPP CCCCCCCCCCCCCCC		25159151
42	Phosphorylation	RAELPPPYTAIASPD CCCCCCCCCEEECCC		25884760
43	Phosphorylation	AELPPPYTAIASPDA CCCCCCCCEEECCCC		27732954
47	Phosphorylation	PPYTAIASPDASGIP CCCCEEECCCCCCCC		28450419
51	Phosphorylation	AIASPDASGIPVINC EEECCCCCCCCEEEC		27732954
70	Ubiquitination	SLINLDGKLHQHVVK HHHCCCCCEEEEEEE		33845483
77	Ubiquitination	KLHQHVVKCTVCNEA CEEEEEEEEEECCCC		32015554
85	Phosphorylation	CTVCNEATPIKNPPT EEECCCCCCCCCCCC		25159151
88	Ubiquitination	CNEATPIKNPPTGKK CCCCCCCCCCCCCCC		22505724
94	Ubiquitination	IKNPPTGKKYVRCPC CCCCCCCCCEEECCC		32142685
134	Phosphorylation	LGPVMLISEEQPAQP ECCEEEECCCCCCCC		27732954
170	Phosphorylation	WMELRFNTLAKCPHC EEEEEHHHHHCCCCC		28060719
185	Phosphorylation	KKISSVGSALPRRRC CCCCCCCCCCCHHHH		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PP4P2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PP4P2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PP4P2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PP4P2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.