dbPTM

TRM11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRM11_HUMAN
UniProt AC	Q7Z4G4
Protein Name	tRNA (guanine(10)-N2)-methyltransferase homolog
Gene Name	TRMT11
Organism	Homo sapiens (Human).
Sequence Length	463
Subcellular Localization
Protein Description	Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs..
Protein Sequence	MALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIARNLMKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLEDYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKWEKCPESHVPVSLSYHLSDMFLDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFENRDQYSHLLSDHFLPYQGHNSFREKYFSGVTKRIAKEEKSTQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALSCTLNR ------CCHHHHHHH	14.26	22223895
5	Carbamidation	---MALSCTLNRYLL ---CCHHHHHHHHHH	5.36	17322306
10	Phosphorylation	LSCTLNRYLLLMAQE HHHHHHHHHHHHHHH	10.71	17322306
39	Phosphorylation	LFGGQFASSQETYGK HHCCCCCCCCCCCCC	33.57	22210691
44	Phosphorylation	FASSQETYGKSPFWI CCCCCCCCCCCCEEE	23.08	22817900
109	Malonylation	LHSDSTYKIKIHTFN CCCCCEEEEEEEECC	37.30	26320211
109	Ubiquitination	LHSDSTYKIKIHTFN CCCCCEEEEEEEECC	37.30	29967540
111	Ubiquitination	SDSTYKIKIHTFNKT CCCEEEEEEEECCCC	25.04	29967540
117	Ubiquitination	IKIHTFNKTLTQEEK EEEEECCCCCCHHHH	40.49	29967540
118	Phosphorylation	KIHTFNKTLTQEEKI EEEECCCCCCHHHHH	35.82	30622161
120	Phosphorylation	HTFNKTLTQEEKIKR EECCCCCCHHHHHHC	38.88	30622161
124	Ubiquitination	KTLTQEEKIKRIDAL CCCCHHHHHHCCCEE	53.42	29967540
139 (in isoform 2)	Ubiquitination	-	22.28	-
139	Ubiquitination	EFLPFEGKVNLKKPQ HHCCCCCCCCCCCCH	22.28	23503661
143	Ubiquitination	FEGKVNLKKPQHVFS CCCCCCCCCCHHHHH	58.15	23503661
144	Ubiquitination	EGKVNLKKPQHVFSV CCCCCCCCCHHHHHH	53.74	23503661
186	Phosphorylation	QRELIESYSVKKRHF CHHHHHHHCCCCCEE	12.51	-
189	Ubiquitination	LIESYSVKKRHFIGN HHHHHCCCCCEECCC	37.84	29967540
261	Ubiquitination	GKATRKNQKWRGPDE CHHCCCCCCCCCCCH	50.12	24816145
295	Phosphorylation	VSDASKPSWRKGTYF ECCCCCCCCCCCCEE	43.16	26091039
311	Phosphorylation	AIITDPPYGIRESTR EEECCCCCCCCHHHC	30.49	-
316	Phosphorylation	PPYGIRESTRRTGSQ CCCCCCHHHCCCCCC	19.84	24719451
317	Phosphorylation	PYGIRESTRRTGSQK CCCCCHHHCCCCCCC	21.29	24719451
322	Phosphorylation	ESTRRTGSQKEIPKG HHHCCCCCCCCCCCC	37.15	24719451
324	Ubiquitination	TRRTGSQKEIPKGIE HCCCCCCCCCCCCHH	60.35	29967540
332	Ubiquitination	EIPKGIEKWEKCPES CCCCCHHHHHHCCCC	59.75	29967540
430	Phosphorylation	DQYSHLLSDHFLPYQ HHHHHHHHHCCCCCC	35.09	28555341
436	Phosphorylation	LSDHFLPYQGHNSFR HHHCCCCCCCCCHHH	29.31	26425664
441	Phosphorylation	LPYQGHNSFREKYFS CCCCCCCHHHHHHHH	21.72	20873877
445	Ubiquitination	GHNSFREKYFSGVTK CCCHHHHHHHHHHHH	47.54	29967540
446	Phosphorylation	HNSFREKYFSGVTKR CCHHHHHHHHHHHHH	9.75	-
448	Phosphorylation	SFREKYFSGVTKRIA HHHHHHHHHHHHHHH	29.30	-
452	Ubiquitination	KYFSGVTKRIAKEEK HHHHHHHHHHHHHHH	39.13	29967540
452	Acetylation	KYFSGVTKRIAKEEK HHHHHHHHHHHHHHH	39.13	25953088
459	Ubiquitination	KRIAKEEKSTQE--- HHHHHHHHHCCC---	60.95	24816145
461	Phosphorylation	IAKEEKSTQE----- HHHHHHHCCC-----	48.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRM11_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRM11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRM11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GALC_HUMAN	GALC	physical	28514442
TR112_HUMAN	TRMT112	physical	28514442
SYNC_HUMAN	NARS	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRM11_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-44, AND MASSSPECTROMETRY.	15592455 [Abstract]