GALC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GALC_HUMAN
• UniProt AC: P54803
• Protein Name: Galactocerebrosidase
• Gene Name: GALC
• Organism: Homo sapiens (Human).
• Sequence Length: 685
• Subcellular Localization: Lysosome.
• Protein Description: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon..
• Protein Sequence: MAEWLLSASWQRRAKAMTAAAGSAGRAAVPLLLCALLAPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNITLIGLPWSFPGWLGKGFDWPYVNLQLTAYYVVTWIVGAKRYHDLDIDYIGIWNERSYNANYIKILRKMLNYQGLQRVKIIASDNLWESISASMLLDAELFKVVDVIGAHYPGTHSAKDAKLTGKKLWSSEDFSTLNSDMGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPVWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHSKCIRPFLPYFNVSQQFATFVLKGSFSEIPELQVWYTKLGKTSERFLFKQLDSLWLLDSDGSFTLSLHEDELFTLTTLTTGRKGSYPLPPKSQPFPSTYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHHFTLRQVLNQRPITWAADASNTISIIGDYNWTNLTIKCDVYIETPDTGGVFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVEVTAKKWYTLTLTIKGHFTSGMLNDKSLWTDIPVNFPKNGWAAIGTHSFEFAQFDNFLVEATR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11 (in isoform 5)	Phosphorylation	-	23.61	24043423
12 (in isoform 5)	Phosphorylation	-	33.98	24043423
15	Acetylation	ASWQRRAKAMTAAAG HHHHHHHHHHHHHHH	36.56	10723477
18	Phosphorylation	QRRAKAMTAAAGSAG HHHHHHHHHHHHHHH	20.29	22985185
68	Phosphorylation	VSGGGATSRLLVNYP CCCCCHHCEEECCCC	22.01	-
143	N-linked_Glycosylation	EAKKRNPNITLIGLP HHHHHCCCEEEEECC	43.35	UniProtKB CARBOHYD
261	Acetylation	YPGTHSAKDAKLTGK CCCCCCHHHCCCCCC	62.32	7964635
379	N-linked_Glycosylation	ALTDGLGNLTIIIET EEECCCCCEEEEEEE	38.77	UniProtKB CARBOHYD
381	Phosphorylation	TDGLGNLTIIIETMS ECCCCCEEEEEEECC	17.71	-
403	N-linked_Glycosylation	RPFLPYFNVSQQFAT CCCCCCCCHHHHHHE	27.04	UniProtKB CARBOHYD
529	Phosphorylation	DPGEHHFTLRQVLNQ CCCCCCEEHHHHHHC	19.37	24719451
556	N-linked_Glycosylation	ISIIGDYNWTNLTIK EEEEECCCCCCEEEE	43.78	UniProtKB CARBOHYD
559	N-linked_Glycosylation	IGDYNWTNLTIKCDV EECCCCCCEEEEEEE	27.14	UniProtKB CARBOHYD
602	N-linked_Glycosylation	IFFWIFANGSYRVTG EEEEEECCCCEEECH	29.24	UniProtKB CARBOHYD
608	Phosphorylation	ANGSYRVTGDLAGWI CCCCEEECHHHHHHH	18.91	-
625	Phosphorylation	ALGRVEVTAKKWYTL HCCCEEEEECCEEEE	21.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GALC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GALC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GALC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEUL4_HUMAN	NEURL4	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.