P20D2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P20D2_HUMAN
• UniProt AC: Q8IYS1
• Protein Name: Peptidase M20 domain-containing protein 2
• Gene Name: PM20D2
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Protein Sequence: MRPGGERPVEGGACNGRSELELLKLRSAECIDEAAERLGALSRAIWSQPELAYEEHHAHRVLTHFFEREPPAASWAVQPHYQLPTAFRAEWEPPEARAPSATPRPLHLGFLCEYDALPGIGHACGHNLIAEVGAAAALGVRGALEGLPRPPPPVKVVVLGTPAEEDGGGKIDLIEAGAFTNLDVVFMAHPSQENAAYLPDMAEHDVTVKYYGKASHSASYPWEGLNALDAAVLAYNNLSVFRQQMKPTWRVHGIIKNGGVKPNIIPSYSELIYYFRAPSMKELQVLTKKAEDCFRAAALASGCTVEIKGGAHDYYNVLPNKSLWKAYMENGRKLGIEFISEDTMLNGPSGSTDFGNVSFVVPGIHPYFHIGSNALNHTEQYTEAAGSQEAQFYTLRTAKALAMTALDVIFKPELLEGIREDFKLKLQEEQFVNAVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Ubiquitination	RSELELLKLRSAECI CHHHHHHHHHCHHHH	55.25	27667366
24	Acetylation	RSELELLKLRSAECI CHHHHHHHHHCHHHH	55.25	26822725
30	Glutathionylation	LKLRSAECIDEAAER HHHHCHHHHHHHHHH	4.80	22555962
47	Phosphorylation	ALSRAIWSQPELAYE HHHHHHHHCHHHHHH	29.73	24043423
53	Phosphorylation	WSQPELAYEEHHAHR HHCHHHHHHHHHHHH	34.18	28796482
81	Phosphorylation	SWAVQPHYQLPTAFR CCCCCCCCCCCCCEE	20.59	-
85	Phosphorylation	QPHYQLPTAFRAEWE CCCCCCCCCEECCCC	47.20	-
102	Ubiquitination	EARAPSATPRPLHLG CCCCCCCCCCCCEEE	24.94	24816145
135	Ubiquitination	LIAEVGAAAALGVRG HHHHHHHHHHHCCHH	6.32	21890473
139	Ubiquitination	VGAAAALGVRGALEG HHHHHHHCCHHHHCC	11.44	22817900
237	Ubiquitination	AAVLAYNNLSVFRQQ HHHHHHCCHHHHHHH	22.48	22817900
239	Ubiquitination	VLAYNNLSVFRQQMK HHHHCCHHHHHHHCC	22.72	22817900
261	Ubiquitination	IIKNGGVKPNIIPSY EEECCCCCCCCCCCH	35.30	-
281	Ubiquitination	YFRAPSMKELQVLTK HHCCCCHHHHHHHHH	60.66	-
288	Ubiquitination	KELQVLTKKAEDCFR HHHHHHHHHHHHHHH	45.91	24816145
303	Glutathionylation	AAALASGCTVEIKGG HHHHHCCCEEEEECC	3.40	22555962
308	Ubiquitination	SGCTVEIKGGAHDYY CCCEEEEECCCCCCC	37.47	-
314	Phosphorylation	IKGGAHDYYNVLPNK EECCCCCCCCCCCCH	6.25	28796482
315	Phosphorylation	KGGAHDYYNVLPNKS ECCCCCCCCCCCCHH	12.59	28796482
321	Ubiquitination	YYNVLPNKSLWKAYM CCCCCCCHHHHHHHH	45.01	21906983
325	Ubiquitination	LPNKSLWKAYMENGR CCCHHHHHHHHHHCC	34.63	22817900
394	Phosphorylation	SQEAQFYTLRTAKAL CHHHHHHHHHHHHHH	15.85	24719451
423	Ubiquitination	EGIREDFKLKLQEEQ HHHHHHHHHHHHHHH	57.97	22817900
425	Ubiquitination	IREDFKLKLQEEQFV HHHHHHHHHHHHHHH	49.03	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P20D2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P20D2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P20D2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1671_HUMAN	KIAA1671	physical	28514442
PRI2_HUMAN	PRIM2	physical	28514442
KITH_HUMAN	TK1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.