dbPTM

KITH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KITH_HUMAN
UniProt AC	P04183
Protein Name	Thymidine kinase, cytosolic
Gene Name	TK1
Organism	Homo sapiens (Human).
Sequence Length	234
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSCINLPTV ------CCCCCCCCC	24.57	30631047
2	Acetylation	------MSCINLPTV ------CCCCCCCCC	24.57	20068231
8	Phosphorylation	MSCINLPTVLPGSPS CCCCCCCCCCCCCCC	37.53	30631047
13	Phosphorylation	LPTVLPGSPSKTRGQ CCCCCCCCCCCCCCC	24.86	29255136
15	Phosphorylation	TVLPGSPSKTRGQIQ CCCCCCCCCCCCCEE	48.64	29255136
16	Ubiquitination	VLPGSPSKTRGQIQV CCCCCCCCCCCCEEE	45.70	-
17	Phosphorylation	LPGSPSKTRGQIQVI CCCCCCCCCCCEEEE	44.35	28464451
30	Phosphorylation	VILGPMFSGKSTELM EEECCCCCCCCHHHH	38.77	21712546
32	Acetylation	LGPMFSGKSTELMRR ECCCCCCCCHHHHHH	53.67	24846093
48	Phosphorylation	RRFQIAQYKCLVIKY HHHHHHHEEEEEEEE	8.47	-
49	Ubiquitination	RFQIAQYKCLVIKYA HHHHHHEEEEEEEEC	14.71	-
54	Acetylation	QYKCLVIKYAKDTRY HEEEEEEEECCCCCC	31.51	26051181
55	Phosphorylation	YKCLVIKYAKDTRYS EEEEEEEECCCCCCC	14.04	-
61	Phosphorylation	KYAKDTRYSSSFCTH EECCCCCCCCCCCCC	18.26	29496907
62	Phosphorylation	YAKDTRYSSSFCTHD ECCCCCCCCCCCCCC	19.06	25159151
63	Phosphorylation	AKDTRYSSSFCTHDR CCCCCCCCCCCCCCC	20.64	29214152
64	Phosphorylation	KDTRYSSSFCTHDRN CCCCCCCCCCCCCCC	20.57	28555341
70	Methylation	SSFCTHDRNTMEALP CCCCCCCCCHHHHHH	32.68	115918525
131	Ubiquitination	LDGTFQRKPFGAILN CCCCCCCCCCCHHHH	33.64	-
164	Acetylation	FREAAYTKRLGTEKE HHHHHHHHCCCCCCE	32.71	19816723
170	Ubiquitination	TKRLGTEKEVEVIGG HHCCCCCCEEEEECC	67.88	21906983
170	2-Hydroxyisobutyrylation	TKRLGTEKEVEVIGG HHCCCCCCEEEEECC	67.88	-
180	2-Hydroxyisobutyrylation	EVIGGADKYHSVCRL EEECCCCHHCHHHHH	44.31	-
180	Acetylation	EVIGGADKYHSVCRL EEECCCCHHCHHHHH	44.31	25953088
180	Ubiquitination	EVIGGADKYHSVCRL EEECCCCHHCHHHHH	44.31	-
181	Phosphorylation	VIGGADKYHSVCRLC EECCCCHHCHHHHHH	10.40	29978859
183	Phosphorylation	GGADKYHSVCRLCYF CCCCHHCHHHHHHHE	21.59	29978859
192	Ubiquitination	CRLCYFKKASGQPAG HHHHHEEECCCCCCC	37.57	-
203	Acetylation	QPAGPDNKENCPVPG CCCCCCCCCCCCCCC	58.65	26051181
203	Ubiquitination	QPAGPDNKENCPVPG CCCCCCCCCCCCCCC	58.65	-
211	Ubiquitination	ENCPVPGKPGEAVAA CCCCCCCCCCCHHHH	43.72	-
211	Acetylation	ENCPVPGKPGEAVAA CCCCCCCCCCCHHHH	43.72	26051181
220	Acetylation	GEAVAARKLFAPQQI CCHHHHHHHCCCHHH	43.14	26051181
220	Ubiquitination	GEAVAARKLFAPQQI CCHHHHHHHCCCHHH	43.14	21890473
230	Glutathionylation	APQQILQCSPAN--- CCHHHHCCCCCC---	4.76	22555962
231	Phosphorylation	PQQILQCSPAN---- CHHHHCCCCCC----	17.68	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
13	S	Phosphorylation	Kinase	CDK1	P06493	PSP
13	S	Phosphorylation	Kinase	CDK2	P24941	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:14701726

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
13	S	Phosphorylation		9575153
Phosphorylated on Ser-13 in mitosis.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KITH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GDF9_HUMAN	GDF9	physical	16169070
CC90B_HUMAN	CCDC90B	physical	16169070
PTPRK_HUMAN	PTPRK	physical	16169070
APLP1_HUMAN	APLP1	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
NC2A_HUMAN	DRAP1	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
TBB2A_HUMAN	TUBB2A	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
G3P_HUMAN	GAPDH	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
P53_HUMAN	TP53	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
CDN1A_HUMAN	CDKN1A	physical	11389691
MOFA1_HUMAN	MRFAP1	physical	21900206
ADDA_HUMAN	ADD1	physical	21900206
TSC2_HUMAN	TSC2	physical	21900206
KIF5A_HUMAN	KIF5A	physical	21900206
HMGX3_HUMAN	HMGXB3	physical	21900206
RXRA_HUMAN	RXRA	physical	21900206
CSAD_HUMAN	CSAD	physical	21900206
PSME1_HUMAN	PSME1	physical	21900206
ABHD4_HUMAN	ABHD4	physical	21900206
ECHB_HUMAN	HADHB	physical	21900206
WIZ_HUMAN	WIZ	physical	21900206
MAST2_HUMAN	MAST2	physical	21900206
PLXA3_HUMAN	PLXNA3	physical	21900206
SNX1_HUMAN	SNX1	physical	21900206
ITSN1_HUMAN	ITSN1	physical	21900206
PTPRK_HUMAN	PTPRK	physical	21900206
GDF9_HUMAN	GDF9	physical	21900206
RM37_HUMAN	MRPL37	physical	21900206
DEAF1_HUMAN	DEAF1	physical	21900206
SMC5_HUMAN	SMC5	physical	21900206
ZBT16_HUMAN	ZBTB16	physical	21900206
ZXDC_HUMAN	ZXDC	physical	21900206
KLH23_HUMAN	KLHL23	physical	21900206
CDK4_HUMAN	CDK4	physical	21900206
GPCP1_HUMAN	GPCPD1	physical	21900206
KI67_HUMAN	MKI67	physical	21900206
SUMO3_HUMAN	SUMO3	physical	21900206
DCOR_HUMAN	ODC1	physical	21900206
TYB4_HUMAN	TMSB4X	physical	21900206
DDAH2_HUMAN	DDAH2	physical	21900206
CHSP1_HUMAN	CARHSP1	physical	21900206
ATS10_HUMAN	ADAMTS10	physical	21900206
HBAP1_HUMAN	HSPBAP1	physical	21900206
HEM1_HUMAN	ALAS1	physical	21900206
CS060_HUMAN	C19orf60	physical	21900206
ACTB_HUMAN	ACTB	physical	21900206
CSN6_HUMAN	COPS6	physical	21900206
DPYL1_HUMAN	CRMP1	physical	21900206
TRI46_HUMAN	TRIM46	physical	21900206
ACTY_HUMAN	ACTR1B	physical	21900206
UBP4_HUMAN	USP4	physical	21900206
DALD3_HUMAN	DALRD3	physical	21900206
TAF1C_HUMAN	TAF1C	physical	21900206
A2MG_HUMAN	A2M	physical	21900206
SP110_HUMAN	SP110	physical	21900206
MED31_HUMAN	MED31	physical	21900206
CENPB_HUMAN	CENPB	physical	21900206
CC90B_HUMAN	CCDC90B	physical	21900206
DC1I1_HUMAN	DYNC1I1	physical	21900206
FBN3_HUMAN	FBN3	physical	21900206
RL13_HUMAN	RPL13	physical	21900206
INP5K_HUMAN	INPP5K	physical	21900206
APLP1_HUMAN	APLP1	physical	21900206
A16L2_HUMAN	ATG16L2	physical	21900206
KLHL5_HUMAN	KLHL5	physical	21900206
FA20C_HUMAN	FAM20C	physical	21900206
MPPD1_HUMAN	MPPED1	physical	21900206
MSH2_HUMAN	MSH2	physical	21900206
AAMP_HUMAN	AAMP	physical	21900206
WDR60_HUMAN	WDR60	physical	21900206
NDF2_HUMAN	NEUROD2	physical	21900206
LRIF1_HUMAN	LRIF1	physical	21900206
INT11_HUMAN	CPSF3L	physical	21900206
IR3IP_HUMAN	IER3IP1	physical	21900206
ZN431_HUMAN	ZNF431	physical	21900206
ACL6B_HUMAN	ACTL6B	physical	21900206
IF4A2_HUMAN	EIF4A2	physical	21900206
JHD2C_HUMAN	JMJD1C	physical	21900206
PP4C_HUMAN	PPP4C	physical	21900206
KPYM_HUMAN	PKM	physical	21900206
AGAP1_HUMAN	AGAP1	physical	21900206
TNR16_HUMAN	NGFR	physical	21900206
PAAF1_HUMAN	PAAF1	physical	21900206
ST1A3_HUMAN	SULT1A3	physical	21900206
ST1A4_HUMAN	SULT1A3	physical	21900206
NMT2_HUMAN	NMT2	physical	21900206
TTC38_HUMAN	TTC38	physical	21900206
SYQ_HUMAN	QARS	physical	21900206
RBBP4_HUMAN	RBBP4	physical	21900206
TETN_HUMAN	CLEC3B	physical	21900206
NRBP_HUMAN	NRBP1	physical	21900206
SETB1_HUMAN	SETDB1	physical	21900206
DMPK_HUMAN	DMPK	physical	21900206
ATX3_HUMAN	ATXN3	physical	21900206
MIC60_HUMAN	IMMT	physical	21900206
CO4A2_HUMAN	COL4A2	physical	21900206
VATA_HUMAN	ATP6V1A	physical	21900206
P53_HUMAN	TP53	physical	21900206
KI21B_HUMAN	KIF21B	physical	21900206
CPNE6_HUMAN	CPNE6	physical	21900206
EXT2_HUMAN	EXT2	physical	21900206
CAB45_HUMAN	SDF4	physical	21900206
TIAM2_HUMAN	TIAM2	physical	21900206
FAD1_HUMAN	FLAD1	physical	21900206
ERG28_HUMAN	C14orf1	physical	21900206
DACT1_HUMAN	DACT1	physical	21900206
SEM5B_HUMAN	SEMA5B	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
RBM48_HUMAN	RBM48	physical	21900206
G3P_HUMAN	GAPDH	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
SEPT6_HUMAN	SEPT6	physical	21900206
F13A_HUMAN	F13A1	physical	21900206
TYK2_HUMAN	TYK2	physical	21900206
EIF3G_HUMAN	EIF3G	physical	21900206
JADE1_HUMAN	JADE1	physical	21900206
RUVB1_HUMAN	RUVBL1	physical	21900206
WDR73_HUMAN	WDR73	physical	21900206
PROC_HUMAN	PROC	physical	21900206
TRM2A_HUMAN	TRMT2A	physical	21900206
TLE1_HUMAN	TLE1	physical	21900206
FST_HUMAN	FST	physical	21900206
THOC3_HUMAN	THOC3	physical	21900206
DCA13_HUMAN	DCAF13	physical	21900206
RS2_HUMAN	RPS2	physical	21900206
TBB2A_HUMAN	TUBB2A	physical	21900206
A1BG_HUMAN	A1BG	physical	21900206
CO4A5_HUMAN	COL4A5	physical	21900206
ATPB_HUMAN	ATP5B	physical	21900206
EF1A1_HUMAN	EEF1A1	physical	21900206
CC115_HUMAN	CCDC115	physical	21900206
GDIA_HUMAN	GDI1	physical	21900206
EZH2_HUMAN	EZH2	physical	21900206
HERC3_HUMAN	HERC3	physical	21900206
U119A_HUMAN	UNC119	physical	21900206
IF6_HUMAN	EIF6	physical	21900206
DUS2L_HUMAN	DUS2	physical	21900206
KBRS2_HUMAN	NKIRAS2	physical	21900206
TBB3_HUMAN	TUBB3	physical	21900206
SCG1_HUMAN	CHGB	physical	21900206
KDM6B_HUMAN	KDM6B	physical	21900206
MYOME_HUMAN	PDE4DIP	physical	21900206
KITH_HUMAN	TK1	physical	21900206
TC1D2_HUMAN	TCTEX1D2	physical	21900206
COBA2_HUMAN	COL11A2	physical	21900206
EM55_HUMAN	MPP1	physical	21900206
CRIP2_HUMAN	CRIP2	physical	21900206
WDR18_HUMAN	WDR18	physical	21900206
MET23_HUMAN	METTL23	physical	21900206
RFA1_HUMAN	RPA1	physical	21900206
ARFG1_HUMAN	ARFGAP1	physical	21900206
PLD3_HUMAN	PLD3	physical	21900206
DOCK7_HUMAN	DOCK7	physical	21900206
ALBU_HUMAN	ALB	physical	21900206
PTN4_HUMAN	PTPN4	physical	21900206
KMT2B_HUMAN	KMT2B	physical	21900206
ASNA_HUMAN	ASNA1	physical	21900206
BGAL_HUMAN	GLB1	physical	21900206
FIBB_HUMAN	FGB	physical	21900206
FAF1_HUMAN	FAF1	physical	21900206
FZR1_HUMAN	FZR1	physical	14701726
CDC20_HUMAN	CDC20	physical	14701726
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00432	Trifluridine
DB00495	Zidovudine

Regulatory Network of KITH_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 AND SER-15, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.	18691976 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Serine 13 is the site of mitotic phosphorylation of human thymidinekinase."; Chang Z.F., Huang D.Y., Chi L.M.; J. Biol. Chem. 273:12095-12100(1998). Cited for: PHOSPHORYLATION AT SER-13.	9575153 [Abstract]

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