SEM5B_HUMAN - dbPTM
SEM5B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SEM5B_HUMAN
UniProt AC Q9P283
Protein Name Semaphorin-5B
Gene Name SEMA5B
Organism Homo sapiens (Human).
Sequence Length 1151
Subcellular Localization Membrane
Single-pass type III membrane protein.
Protein Description May act as positive axonal guidance cues..
Protein Sequence MPCGFSPSPVAHHLVPGPPDTPAQQLRCGWTVGGWLLSLVRGLLPCLPPGARTAEGPIMVLAGPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIVAGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNVTRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLDCLGPAIHIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACENGNSCLGCGVEFKTCNPEGCPEVRRNTPWTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCPYSEIPVILPASSMEEATDCAGFNLIHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKGGGTPKNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKHSFRPEASPGQRCFPNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38PhosphorylationTVGGWLLSLVRGLLP
CHHHHHHHHHHHHHC		23.7324719451
127PhosphorylationYPGARDFSQLALDPS
CCCCCCHHHEEECCC		28.6825850435
153N-linked_GlycosylationLFRLSLANVSLLQAT
HHHHHHHCHHHHHHH		29.24UniProtKB CARBOHYD
201PhosphorylationRKVFMCGTNAFSPMC
CEEEEECCCCCCCHH		20.60-
219PhosphorylationQVGNLSRTIEKINGV
CCCCHHHHHHHHCCE		30.06-
236N-linked_GlycosylationCPYDPRHNSTAVISS
CCCCCCCCCEEEEEC		42.19UniProtKB CARBOHYD
248PhosphorylationISSQGELYAATVIDF
EECCCEEEEEEEEEC		7.01-
263PhosphorylationSGRDPAIYRSLGSGP
CCCCHHHHHHCCCCC		9.03-
274PhosphorylationGSGPPLRTAQYNSKW
CCCCCCCCHHCCCCC		26.2922461510
277PhosphorylationPPLRTAQYNSKWLNE
CCCCCHHCCCCCCCC		20.9522461510
337PhosphorylationFLLEDTWTTFMKARL
EEEECHHHHHHHHHH		16.55-
345N-linked_GlycosylationTFMKARLNCSRPGEV
HHHHHHHCCCCCCCC		19.03UniProtKB CARBOHYD
436N-linked_GlycosylationPETGPNENLTERSLQ
CCCCCCCCCCHHHHH		59.92UniProtKB CARBOHYD
441PhosphorylationNENLTERSLQDAQRL
CCCCCHHHHHHHHHH		24.9328258704
465PhosphorylationVTPEPCVTQDSVRFS
CCCCCCCCCCCCCHH		33.1228258704
468PhosphorylationEPCVTQDSVRFSHLV
CCCCCCCCCCHHHHH		12.8428258704
561PhosphorylationERCAAYRSQGACLGA
HHHHHHHHCCCCCCC		21.9325159151
690PhosphorylationGFQVRQRSCSNPAPR
CCEEEECCCCCCCCC		17.3526699800
692PhosphorylationQVRQRSCSNPAPRHG
EEEECCCCCCCCCCC		47.2826699800
735PhosphorylationWGSWSKCSSNCGGGM
CCCCCHHCCCCCCCH		28.46-
736PhosphorylationGSWSKCSSNCGGGMQ
CCCCHHCCCCCCCHH		45.68-
744PhosphorylationNCGGGMQSRRRACEN
CCCCCHHHHHHHHHC		20.89-
788O-linked_GlycosylationPWLPVNVTQGGARQE
CCCCCEECCCCCCCH		19.12UniProtKB CARBOHYD
864PhosphorylationAAWGPWSSCSRDCEL
CCCCCHHHCCCCCCC		16.55-
1087PhosphorylationLHYKGGGTPKNEKYT
CCCCCCCCCCCCCCC		34.0722817900
1093PhosphorylationGTPKNEKYTPMEFKT
CCCCCCCCCCCEEEC		15.1929083192
1094PhosphorylationTPKNEKYTPMEFKTL
CCCCCCCCCCEEECC		27.5129083192
1100PhosphorylationYTPMEFKTLNKNNLI
CCCCEEECCCCCCCC		40.6729083192
1120PhosphorylationNFYPLQQTNVYTTTY
CCCCCCCCCEEEEEE		17.4324173317
1123PhosphorylationPLQQTNVYTTTYYPS
CCCCCCEEEEEECCC		10.6324173317
1142PhosphorylationHSFRPEASPGQRCFP
CCCCCCCCCCCCCCC		28.09-
1151PhosphorylationGQRCFPNS-------
CCCCCCCC-------		41.6630576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SEM5B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SEM5B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SEM5B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SEM5B_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SEM5B_HUMAN

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Related Literatures of Post-Translational Modification

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