CPNE6_HUMAN - dbPTM
CPNE6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CPNE6_HUMAN
UniProt AC O95741
Protein Name Copine-6 {ECO:0000305}
Gene Name CPNE6 {ECO:0000312|HGNC:HGNC:2319}
Organism Homo sapiens (Human).
Sequence Length 557
Subcellular Localization Cytoplasm . Cell membrane . Endosome . Cytoplasmic vesicle, clathrin-coated vesicle . Perikaryon . Cell projection, dendrite . Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium. Translocates to t
Protein Description Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes. [PubMed: 23999003]
Protein Sequence MSDPEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRAVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPRGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPCTLATTPSPSP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDPEMGWV
------CCCCCCCCC		62.97-
14PhosphorylationGWVPEPPTMTLGASR
CCCCCCCCEEECCCE		33.2423663014
16PhosphorylationVPEPPTMTLGASRVE
CCCCCCEEECCCEEE		25.2323663014
20PhosphorylationPTMTLGASRVELRVS
CCEEECCCEEEEEEE		34.7523663014
68PhosphorylationEVLRSCSSPVFSRVL
HHHHHCCCHHHHHHH		29.4328857561
100PhosphorylationDAEDGATSPRNDTFL
ECCCCCCCCCCCCCC		22.7125332170
124PhosphorylationIVSQTKVTKPLLLKN
HHHCCCCCCCEEEEC		28.6224114839
170PhosphorylationLDNKDLFSKSDPFME
ECCHHHCCCCCCCCE		38.2524719451
179PhosphorylationSDPFMEIYKTNEDQS
CCCCCEEEECCCCCC		9.8420860994
186PhosphorylationYKTNEDQSDQLVWRT
EECCCCCCCCEEEEE		39.3820860994
322PhosphorylationASNGDPRSSQSLHCL
CCCCCCCCCCEEEEC		37.8128857561
323PhosphorylationSNGDPRSSQSLHCLS
CCCCCCCCCEEEECC		25.6828857561
330PhosphorylationSQSLHCLSPRQPNHY
CCEEEECCCCCCCHH		24.3528857561
436PhosphorylationTGQATKYSVLLVLTD
CCCCCEEEEEEEEEC		14.0829759185
442PhosphorylationYSVLLVLTDGVVSDM
EEEEEEEECCCHHCH		24.1920860994
447PhosphorylationVLTDGVVSDMAETRT
EEECCCHHCHHHHHH		21.1820860994
452PhosphorylationVVSDMAETRTAIVRA
CHHCHHHHHHHHHHH		24.6329759185
460PhosphorylationRTAIVRASRLPMSII
HHHHHHHHHCCCEEE		24.6422817900
465PhosphorylationRASRLPMSIIIVGVG
HHHHCCCEEEEEEEC		14.5418669648
533PhosphorylationVPRQVVEYYASQGIS
CCHHHHHHHHHCCCC		7.8529888752
534PhosphorylationPRQVVEYYASQGISP
CHHHHHHHHHCCCCC		6.0529888752
536PhosphorylationQVVEYYASQGISPGA
HHHHHHHHCCCCCCC		16.9029888752
540PhosphorylationYYASQGISPGAPRPC
HHHHCCCCCCCCCCC		24.8929888752
548PhosphorylationPGAPRPCTLATTPSP
CCCCCCCEECCCCCC		23.3129888752
551PhosphorylationPRPCTLATTPSPSP-
CCCCEECCCCCCCC-		42.2129888752
552PhosphorylationRPCTLATTPSPSP--
CCCEECCCCCCCC--		19.0329888752
554PhosphorylationCTLATTPSPSP----
CEECCCCCCCC----		35.6029888752
556PhosphorylationLATTPSPSP------
ECCCCCCCC------		47.8029888752
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CPNE6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CPNE6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CPNE6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KAD5_HUMANAK5physical
16169070
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CPNE6_HUMAN

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Related Literatures of Post-Translational Modification

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