KAD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAD5_HUMAN
• UniProt AC: Q9Y6K8
• Protein Name: Adenylate kinase isoenzyme 5
• Gene Name: AK5
• Organism: Homo sapiens (Human).
• Sequence Length: 562
• Subcellular Localization: Cytoplasm .
• Protein Description: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity..
• Protein Sequence: MNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MNTNDAKEYLARRE -CCHHHHHHHHHHCH	50.16	30230243
37	Phosphorylation	KPEDPVEYLESCLQK CCCCHHHHHHHHHHH	18.92	10814883
39	Ubiquitination	EDPVEYLESCLQKVK CCHHHHHHHHHHHHH	38.20	30230243
65	Ubiquitination	TFVSQEKKTLPPLNG HCCCCCCCCCCCCCC	55.32	30230243
92	Phosphorylation	PENSNFPYRRYDRLP CCCCCCCCCCCCCCC	12.00	11391681
105	Phosphorylation	LPPIHQFSIESDTDL CCCCCCCEECCCCCH	20.90	27732954
108	Phosphorylation	IHQFSIESDTDLSET CCCCEECCCCCHHHH	44.11	27732954
110	Phosphorylation	QFSIESDTDLSETAE CCEECCCCCHHHHHH	48.39	27732954
113	Phosphorylation	IESDTDLSETAELIE ECCCCCHHHHHHHHH	35.39	27732954
115	Phosphorylation	SDTDLSETAELIEEY CCCCHHHHHHHHHHH	23.27	27732954
119	Ubiquitination	LSETAELIEEYEVFD HHHHHHHHHHHCCCC	2.59	30230243
125	Ubiquitination	LIEEYEVFDPTRPRP HHHHHCCCCCCCCCC	6.60	30230243
143	Phosphorylation	LVIGGPGSGKGTQSL EEECCCCCCCCHHHH	40.23	50564321
145	Ubiquitination	IGGPGSGKGTQSLKI ECCCCCCCCHHHHHH	61.56	30230243
151	Ubiquitination	GKGTQSLKIAERYGF CCCHHHHHHHHHHCC	45.15	30230243
177	Ubiquitination	KIHSTSSNRKWSLIA HHHCCCCCCCCEEEE	49.68	30230243
179	Ubiquitination	HSTSSNRKWSLIAKI HCCCCCCCCEEEEEE	45.44	30230243
179	Acetylation	HSTSSNRKWSLIAKI HCCCCCCCCEEEEEE	45.44	19827779
181	Phosphorylation	TSSNRKWSLIAKIIT CCCCCCCEEEEEEHH	16.97	24247654
185	Acetylation	RKWSLIAKIITTGEL CCCEEEEEEHHHCCC	27.87	19827785
203	Ubiquitination	ETTITEIKQKLMQIP CCCHHHHHHHHCCCC	34.84	30230243
205	Ubiquitination	TITEIKQKLMQIPDE CHHHHHHHHCCCCCC	40.71	30230243
243	Ubiquitination	TPDLVVFLACANQRL CHHHHHHHHHHCHHH	2.30	30230243
253	Ubiquitination	ANQRLKERLLKRAEQ HCHHHHHHHHHHHHH	43.67	30230243
269	Ubiquitination	GRPDDNVKATQRRLM CCCCCCHHHHHHHHH	52.55	30230243
279	Ubiquitination	QRRLMNFKQNAAPLV HHHHHHHHHCHHHHH	37.32	30230243
279	Malonylation	QRRLMNFKQNAAPLV HHHHHHHHHCHHHHH	37.32	26320211
369	Ubiquitination	GEDTMGGFMEDLRKC CCCCCCCHHHHHHCC	3.92	30230243
373	Ubiquitination	MGGFMEDLRKCKIIF CCCHHHHHHCCEEEE	3.43	30230243
395	Ubiquitination	GKGTQCEKLVEKYGF CCCHHHHHHHHHHCC	66.51	30230243
399	Ubiquitination	QCEKLVEKYGFTHLS HHHHHHHHHCCCCCC	43.10	30230243
442	Ubiquitination	VPSGIVLELLKEAMV CCCCHHHHHHHHHHH	40.96	30230243
468	Ubiquitination	DGYPREVKQGEEFGR CCCCCCCCCCHHHHH	48.08	30230243
501	Phosphorylation	TNRLLQRSRSSLPVD HHHHHHHHHCCCCCC	24.45	27732954
503	Phosphorylation	RLLQRSRSSLPVDDT HHHHHHHCCCCCCHH	37.16	27251275
504	Phosphorylation	LLQRSRSSLPVDDTT HHHHHHCCCCCCHHH	35.27	24076635
521	Phosphorylation	IAKRLEAYYRASIPV HHHHHHHHHHCCCCE	5.54	9341643
522	Phosphorylation	AKRLEAYYRASIPVI HHHHHHHHHCCCCEE	13.52	9341653
532	Phosphorylation	SIPVIAYYETKTQLH CCCEEEEEECCCHHC	14.22	9341655

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAD5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of KAD5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.