A1BG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: A1BG_HUMAN
• UniProt AC: P04217
• Protein Name: Alpha-1B-glycoprotein
• Gene Name: A1BG
• Organism: Homo sapiens (Human).
• Sequence Length: 495
• Subcellular Localization: Secreted.
• Protein Sequence: MSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLANVTLTCQAHLETPDFQLFKNGVAQEPVHLDSPAIKHQFLLTGDTQGRYRCRSGLSTGWTQLSKLLELTGPKSLPAPWLSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLEVPEAQEDVEATFPVHQPGNYSCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNKVTLTCVAPLSGVDFQLRRGEKELLVPRSSTSPDRIFFHLNAVALGDGGHYTCRYRLHDNQNGWSGDSAPVELILSDETLPAPEFSPEPESGRALRLRCLAPLEGARFALVREDRGGRRVHRFQSPAGTEALFELHNISVADSANYSCVYVDLKPPFGGSAPSERLELHVDGPPPRPQLRATWSGAVLAGRDAVLRCEGPIPDVTFELLREGETKAVKTVRTPGAAANLELIFVGPQHAGNYRCRYRSWVPHTFESELSDPVELLVAES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	SLWAESESLLKPLAN CHHCCCHHHHHHHCC	48.56	24719451
44	N-linked_Glycosylation	SLLKPLANVTLTCQA HHHHHHCCCEEEEEE	34.68	19838169
44	N-linked_Glycosylation	SLLKPLANVTLTCQA HHHHHHCCCEEEEEE	34.68	14760718
179	N-linked_Glycosylation	FPVHQPGNYSCSYRT CCCCCCCCCEEEEEC	32.03	18638581
179	N-linked_Glycosylation	FPVHQPGNYSCSYRT CCCCCCCCCEEEEEC	32.03	14760718
198	O-linked_Glycosylation	ALSEPSATVTIEELA CCCCCCEEEEHHHHC	23.63	OGP
363	N-linked_Glycosylation	EALFELHNISVADSA HHHHHEECCCHHHCC	40.63	16335952
363	N-linked_Glycosylation	EALFELHNISVADSA HHHHHEECCCHHHCC	40.63	16335952
371	N-linked_Glycosylation	ISVADSANYSCVYVD CCHHHCCCCEEEEEE	32.95	16335952
371	N-linked_Glycosylation	ISVADSANYSCVYVD CCHHHCCCCEEEEEE	32.95	16335952

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of A1BG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of A1BG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of A1BG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MRP6_HUMAN	ABCC6	physical	21988832
PRDX4_HUMAN	PRDX4	physical	21988832
SETD7_HUMAN	SETD7	physical	21988832
ZBT40_HUMAN	ZBTB40	physical	28514442
PSME4_HUMAN	PSME4	physical	28514442
UBAC1_HUMAN	UBAC1	physical	28514442
WDR62_HUMAN	WDR62	physical	28514442
KCMF1_HUMAN	KCMF1	physical	28514442
RN123_HUMAN	RNF123	physical	28514442
UBR4_HUMAN	UBR4	physical	28514442
UBXN1_HUMAN	UBXN1	physical	28514442
ADRO_HUMAN	FDXR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Enrichment of glycopeptides for glycan structure and attachment siteidentification.";
Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E.,Brinkmalm G., Larson G.;
Nat. Methods 6:809-811(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, STRUCTURE OFCARBOHYDRATES, AND MASS SPECTROMETRY.
PubMed: 19838169

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44; ASN-179; ASN-363 ANDASN-371, AND MASS SPECTROMETRY.
PubMed: 16335952

"Screening for N-glycosylated proteins by liquid chromatography massspectrometry.";
Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.;
Proteomics 4:454-465(2004).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44 AND ASN-179, AND MASSSPECTROMETRY.
PubMed: 14760718

"Amino acid sequence of human plasma alpha 1B-glycoprotein: homologyto the immunoglobulin supergene family.";
Ishioka N., Takahashi N., Putnam F.W.;
Proc. Natl. Acad. Sci. U.S.A. 83:2363-2367(1986).
Cited for: PROTEIN SEQUENCE OF 22-495, DISULFIDE BONDS, GLYCOSYLATION AT ASN-44;ASN-179; ASN-363 AND ASN-371, AND VARIANT ARG-52.
PubMed: 3458201