| UniProt ID | SETD7_HUMAN | |
|---|---|---|
| UniProt AC | Q8WTS6 | |
| Protein Name | Histone-lysine N-methyltransferase SETD7 | |
| Gene Name | SETD7 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 366 | |
| Subcellular Localization | Nucleus. Chromosome . | |
| Protein Description | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.. | |
| Protein Sequence | MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MDSDDEMVEE -----CCCHHHHHHH | 45.74 | 25849741 | |
| 45 | Ubiquitination | GNFVHGEKNGRGKFF CCEECCEECCCEEEE | 70.10 | - | |
| 85 | Phosphorylation | DGGVLQGTYVDGELN CCCEEEEEEECCCCC | 13.86 | 22468782 | |
| 86 | Phosphorylation | GGVLQGTYVDGELNG CCEEEEEEECCCCCC | 11.90 | 22468782 | |
| 111 | Ubiquitination | LIFKGQYKDNIRHGV EEEEEECCCCCCEEE | 36.09 | - | |
| 152 | Methylation | AYVYPDERTALYGKF EEECCCCCCEEEEEE | 32.45 | 115916529 | |
| 158 | Ubiquitination | ERTALYGKFIDGEMI CCCEEEEEECCCEEE | 26.11 | - | |
| 224 | Phosphorylation | YVAESLISSAGEGLF HHHHHHHHHCCCCCC | 21.30 | 28348404 | |
| 225 | Phosphorylation | VAESLISSAGEGLFS HHHHHHHHCCCCCCC | 33.04 | 28348404 | |
| 232 | Phosphorylation | SAGEGLFSKVAVGPN HCCCCCCCEEEECCC | 31.12 | 24719451 | |
| 305 | Phosphorylation | SFTPNCIYDMFVHPR CCCCCCEEEECCCCC | 11.98 | - | |
| 332 | Phosphorylation | VEADEELTVAYGYDH EECCCEEEEEECCCC | 13.33 | 21712546 | |
| 335 | Phosphorylation | DEELTVAYGYDHSPP CCEEEEEECCCCCCC | 16.33 | 21712546 | |
| 337 | Phosphorylation | ELTVAYGYDHSPPGK EEEEEECCCCCCCCC | 9.60 | 21712546 | |
| 340 | Phosphorylation | VAYGYDHSPPGKSGP EEECCCCCCCCCCCC | 29.86 | 25159151 | |
| 345 | Phosphorylation | DHSPPGKSGPEAPEW CCCCCCCCCCCCCCE | 66.55 | 25159151 | |
| 358 | Ubiquitination | EWYQVELKAFQATQQ CEEEEHHHHHHHHHC | 33.38 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SETD7_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SETD7_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SETD7_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
