LMBL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMBL1_HUMAN
• UniProt AC: Q9Y468
• Protein Name: Lethal(3)malignant brain tumor-like protein 1
• Gene Name: L3MBTL1
• Organism: Homo sapiens (Human).
• Sequence Length: 840
• Subcellular Localization: Nucleus . Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
• Protein Description: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis..
• Protein Sequence: MHLVAGDSPGSGPHLPATAFIIPASSATLGLPSSALDVSCFPREPIHVGAPEQVAGCEPVSATVLPQLSAGPASSSTSTVRLLEWTEAAAPPPGGGLRFRISEYKPLNMAGVEQPPSPELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQCQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKKRKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATGEKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFLVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFHHRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASARKKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSALSAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCEDQARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVHSLLCSLPTHLLAKLSFASDSQY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	PREPIHVGAPEQVAG CCCCCCCCCHHHHCC	37.38	23401153
117	Phosphorylation	AGVEQPPSPELRQEG CCCCCCCCHHHHHCC	36.82	23186163
160	Phosphorylation	PEDPNQDPPEDDSTC CCCCCCCCCCCCCCC	63.99	28348404
164	Phosphorylation	NQDPPEDDSTCQCQA CCCCCCCCCCCCCCC	62.83	28348404
199	Phosphorylation	LFQERSVIVENSSGS HHHCCEEEEECCCCC	53.18	28674151
232	Phosphorylation	QSPSEEESEPEAMEK CCCCHHHCCHHHHHH	23.81	-
299	Phosphorylation	LFQDSQAVTHNKNGF HHCCCCCCCCCCCCC	37.00	24260401
605	Phosphorylation	GCPPLSYRSLPHTRT CCCCCCCCCCCCCCC	47.38	23403867
728	Phosphorylation	HPDRSLSVCWEQHCK CCCCCHHHHHHHHHH	21.41	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMBL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMBL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMBL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMBL1_HUMAN	L3MBTL1	physical	12588862
ETV7_HUMAN	ETV7	physical	12588862
RB_HUMAN	RB1	physical	17540172
CBX3_HUMAN	CBX3	physical	17540172
CBX5_HUMAN	CBX5	physical	17540172
SETD7_HUMAN	SETD7	physical	18408754
H14_HUMAN	HIST1H1E	physical	19144645
P53_HUMAN	TP53	physical	20870725
KMT5A_HUMAN	SETD8	physical	20870725
MCM2_HUMAN	MCM2	physical	21149733
MCM3_HUMAN	MCM3	physical	21149733
MCM4_HUMAN	MCM4	physical	21149733
MCM5_HUMAN	MCM5	physical	21149733
MCM6_HUMAN	MCM6	physical	21149733
MCM7_HUMAN	MCM7	physical	21149733
CDC45_HUMAN	CDC45	physical	21149733
PCNA_HUMAN	PCNA	physical	21149733
TERA_HUMAN	VCP	physical	22120668
TERA_HUMAN	VCP	physical	23652004
ZN644_HUMAN	ZNF644	physical	28514442
SATB2_HUMAN	SATB2	physical	28514442
SAM11_HUMAN	SAMD11	physical	28514442
F208B_HUMAN	FAM208B	physical	28514442
WIZ_HUMAN	WIZ	physical	28514442
EHMT2_HUMAN	EHMT2	physical	28514442
ZN195_HUMAN	ZNF195	physical	28514442
APC1_HUMAN	ANAPC1	physical	28514442
EHMT1_HUMAN	EHMT1	physical	28514442
CBX2_HUMAN	CBX2	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
APC5_HUMAN	ANAPC5	physical	28514442
ZBT34_HUMAN	ZBTB34	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
ZN281_HUMAN	ZNF281	physical	28514442
EVI1_HUMAN	MECOM	physical	28514442
SP16H_HUMAN	SUPT16H	physical	28514442
NSE4A_HUMAN	NSMCE4A	physical	28514442
P73_HUMAN	TP73	physical	28514442
MCM4_HUMAN	MCM4	physical	28514442
PHF10_HUMAN	PHF10	physical	28514442
BRCA2_HUMAN	BRCA2	physical	28514442
Z324A_HUMAN	ZNF324	physical	28514442
SALL2_HUMAN	SALL2	physical	28514442
MCM2_HUMAN	MCM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.