SAM11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAM11_HUMAN
• UniProt AC: Q96NU1
• Protein Name: Sterile alpha motif domain-containing protein 11
• Gene Name: SAMD11
• Organism: Homo sapiens (Human).
• Sequence Length: 681
• Subcellular Localization: Nucleus.
• Protein Description: May play a role in photoreceptor development..
• Protein Sequence: MSKGILQVHPPICDCPGCRISSPVNRGRLADKRTVALPAARNLKKERTPSFSASDGDSDGSGPTCGRRPGLKQEDGPHIRIMKRRVHTHWDVNISFREASCSQDGNLPTLISSVHRSRHLVMPEHQSRCEFQRGSLEIGLRPAGDLLGKRLGRSPRISSDCFSEKRARSESPQEALLLPRELGPSMAPEDHYRRLVSALSEASTFEDPQRLYHLGLPSHGEDPPWHDPPHHLPSHDLLRVRQEVAAAALRGPSGLEAHLPSSTAGQRRKQGLAQHREGAAPAAAPSFSERELPQPPPLLSPQNAPHVALGPHLRPPFLGVPSALCQTPGYGFLPPAQAEMFAWQQELLRKQNLARLELPADLLRQKELESARPQLLAPETALRPNDGAEELQRRGALLVLNHGAAPLLALPPQGPPGSGPPTPSRDSARRAPRKGGPGPASARPSESKEMTGARLWAQDGSEDEPPKDSDGEDPETAAVGCRGPTPGQAPAGGAGAEGKGLFPGSTLPLGFPYAVSPYFHTGAVGGLSMDGEEAPAPEDVTKWTVDDVCSFVGGLSGCGEYTRVFREQGIDGETLPLLTEEHLLTNMGLKLGPALKIRAQVARRLGRVFYVASFPVALPLQPPTLRAPERELGTGEQPLSPTTATSPYGGGHALAGQTSPKQENGTLALLPGAPDPSQPLC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	FSASDGDSDGSGPTC CCCCCCCCCCCCCCC	49.77	-
64	Phosphorylation	DSDGSGPTCGRRPGL CCCCCCCCCCCCCCC	30.99	-
72	Sumoylation	CGRRPGLKQEDGPHI CCCCCCCCCCCCCCE	58.52	28112733
88	Phosphorylation	IMKRRVHTHWDVNIS EEECCEECCCEEEEE	23.08	30206219
95	Phosphorylation	THWDVNISFREASCS CCCEEEEEEEEECCC	17.04	24719451
100	Phosphorylation	NISFREASCSQDGNL EEEEEEECCCCCCCH	15.00	24719451
113	Phosphorylation	NLPTLISSVHRSRHL CHHHHHHHHHHHCCC	18.23	24719451
117	Phosphorylation	LISSVHRSRHLVMPE HHHHHHHHCCCCCHH	14.80	23312004
169	Phosphorylation	FSEKRARSESPQEAL CCHHHHCCCCHHHHH	41.25	22617229
171	Phosphorylation	EKRARSESPQEALLL HHHHCCCCHHHHHHC	32.88	22617229
171 (in isoform 5)	Phosphorylation	-	32.88	25849741
171 (in isoform 4)	Phosphorylation	-	32.88	25849741
253	Phosphorylation	AAALRGPSGLEAHLP HHHHCCCCCHHHCCC	59.85	23186163
262	Phosphorylation	LEAHLPSSTAGQRRK HHHCCCCCCHHHHHH	21.97	23186163
263	Phosphorylation	EAHLPSSTAGQRRKQ HHCCCCCCHHHHHHH	38.86	23186163
418	Phosphorylation	PPQGPPGSGPPTPSR CCCCCCCCCCCCCCH	54.63	27732954
422	Phosphorylation	PPGSGPPTPSRDSAR CCCCCCCCCCHHHHH	36.71	27732954
424	Phosphorylation	GSGPPTPSRDSARRA CCCCCCCCHHHHHCC	51.72	27732954
445	Phosphorylation	GPASARPSESKEMTG CCCCCCCCCCCCCCC	49.28	28555341
461	Phosphorylation	RLWAQDGSEDEPPKD EEEECCCCCCCCCCC	50.60	22167270
469	Phosphorylation	EDEPPKDSDGEDPET CCCCCCCCCCCCHHH	54.35	22167270
476	Phosphorylation	SDGEDPETAAVGCRG CCCCCHHHCCCCCCC	25.88	29978859
482	Methylation	ETAAVGCRGPTPGQA HHCCCCCCCCCCCCC	48.47	115388157
485	Phosphorylation	AVGCRGPTPGQAPAG CCCCCCCCCCCCCCC	42.76	28857561
561	Phosphorylation	GLSGCGEYTRVFREQ CCCCCCHHHHHHHHC	5.78	-
562	Phosphorylation	LSGCGEYTRVFREQG CCCCCHHHHHHHHCC	18.96	-
596	Ubiquitination	LKLGPALKIRAQVAR CCCCHHHHHHHHHHH	32.05	33845483
634	Phosphorylation	APERELGTGEQPLSP CCCCCCCCCCCCCCC	50.61	23663014
640	Phosphorylation	GTGEQPLSPTTATSP CCCCCCCCCCCCCCC	27.21	30175587
642	Phosphorylation	GEQPLSPTTATSPYG CCCCCCCCCCCCCCC	26.20	23663014
643	Phosphorylation	EQPLSPTTATSPYGG CCCCCCCCCCCCCCC	31.18	21712546
645	Phosphorylation	PLSPTTATSPYGGGH CCCCCCCCCCCCCCC	28.30	23663014
646	Phosphorylation	LSPTTATSPYGGGHA CCCCCCCCCCCCCCC	17.41	23663014
648	Phosphorylation	PTTATSPYGGGHALA CCCCCCCCCCCCCCC	28.33	23663014
658	Phosphorylation	GHALAGQTSPKQENG CCCCCCCCCCCCCCC	46.18	23663014
659	Phosphorylation	HALAGQTSPKQENGT CCCCCCCCCCCCCCC	23.39	23663014
666	Phosphorylation	SPKQENGTLALLPGA CCCCCCCCEEECCCC	22.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAM11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAM11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAM11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SAM11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.