dbPTM

ZN281_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN281_HUMAN
UniProt AC	Q9Y2X9
Protein Name	Zinc finger protein 281
Gene Name	ZNF281
Organism	Homo sapiens (Human).
Sequence Length	895
Subcellular Localization	Nucleus .
Protein Description	Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes..
Protein Sequence	MKIGSGFLSGGGGTGSSGGSGSGGGGSGGGGGGGSSGRRAEMEPTFPQGMVMFNHRLPPVTSFTRPAGSAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFLQSLVSIKQEKPADPEEQQSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVLLSSSSRTDDHHGTEEPKQDTNVKKAKRPKPESQGIKAKRKPSASSKPSLVGDGEGAILSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSAEPGSSNHTNMGNLAVLSQGNTSSSRRKTKSKSIAIENKEQKTGKTNESQISNNINMQSYSVEMPTVSSSGGIIGTGIDELQKRVPKLIFKKGSRKNTDKNYLNFVSPLPDIVGQKSLSGKPSGSLGIVSNNSVETIGLLQSTSGKQGQISSNYDDAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIPDEVLQSILDQYSNKSESQKEDPFNIAEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKASMLQEYSKYLQQAFEKSTNASFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQSVTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQSSSQKLTSQKEQKNLESSTGFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSGSRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Sumoylation	------MKIGSGFLS ------CCCCCCCCC	56.63	-
2	Sumoylation	------MKIGSGFLS ------CCCCCCCCC	56.63	28112733
5	O-linked_Glycosylation	---MKIGSGFLSGGG ---CCCCCCCCCCCC	29.82	30059200
5	Phosphorylation	---MKIGSGFLSGGG ---CCCCCCCCCCCC	29.82	28674151
9	Phosphorylation	KIGSGFLSGGGGTGS CCCCCCCCCCCCCCC	32.88	20068231
14	Phosphorylation	FLSGGGGTGSSGGSG CCCCCCCCCCCCCCC	36.85	20068231
16	Phosphorylation	SGGGGTGSSGGSGSG CCCCCCCCCCCCCCC	26.16	30576142
16	O-linked_Glycosylation	SGGGGTGSSGGSGSG CCCCCCCCCCCCCCC	26.16	30059200
17	Phosphorylation	GGGGTGSSGGSGSGG CCCCCCCCCCCCCCC	48.82	20068231
20	O-linked_Glycosylation	GTGSSGGSGSGGGGS CCCCCCCCCCCCCCC	33.05	30059200
20	Phosphorylation	GTGSSGGSGSGGGGS CCCCCCCCCCCCCCC	33.05	30576142
22	Phosphorylation	GSSGGSGSGGGGSGG CCCCCCCCCCCCCCC	35.64	25954137
27	Phosphorylation	SGSGGGGSGGGGGGG CCCCCCCCCCCCCCC	37.22	25954137
35	Phosphorylation	GGGGGGGSSGRRAEM CCCCCCCCCCCCCCC	32.66	27251789
36	Phosphorylation	GGGGGGSSGRRAEME CCCCCCCCCCCCCCC	39.32	20068231
66	Ubiquitination	PVTSFTRPAGSAAPP CCCCCCCCCCCCCCC	37.60	-
101	Sumoylation	PAPDMTFKKEPAASA CCCCCCCCCCCCCCC	47.24	28112733
102	Ubiquitination	APDMTFKKEPAASAA CCCCCCCCCCCCCCC	65.81	-
107	O-linked_Glycosylation	FKKEPAASAAAFPSQ CCCCCCCCCCCCCCC	22.13	30059200
116	Phosphorylation	AAFPSQRTSWGFLQS CCCCCCHHHHHHHHH	22.61	28450419
117	Phosphorylation	AFPSQRTSWGFLQSL CCCCCHHHHHHHHHH	27.65	29496963
128	Sumoylation	LQSLVSIKQEKPADP HHHHHHHHCCCCCCH	44.92	-
128	Sumoylation	LQSLVSIKQEKPADP HHHHHHHHCCCCCCH	44.92	28112733
160	Phosphorylation	FAGAEERSPGLGGGE CCCCCCCCCCCCCCC	26.97	29255136
170	Phosphorylation	LGGGEGGSHGVIQDL CCCCCCCCCCHHCHH	28.11	27251275
177	Ubiquitination	SHGVIQDLSILHQHV CCCHHCHHHHHHHHH	1.64	-
178	Phosphorylation	HGVIQDLSILHQHVQ CCHHCHHHHHHHHHH	31.24	27251275
198	Phosphorylation	HHRDVLLSSSSRTDD HCCCEECCCCCCCCC	24.82	23401153
199	Phosphorylation	HRDVLLSSSSRTDDH CCCEECCCCCCCCCC	32.10	29255136
200	Phosphorylation	RDVLLSSSSRTDDHH CCEECCCCCCCCCCC	22.06	29255136
201	Phosphorylation	DVLLSSSSRTDDHHG CEECCCCCCCCCCCC	40.94	29255136
203	Phosphorylation	LLSSSSRTDDHHGTE ECCCCCCCCCCCCCC	47.96	20873877
209	Phosphorylation	RTDDHHGTEEPKQDT CCCCCCCCCCCCCCC	32.58	29978859
213	Sumoylation	HHGTEEPKQDTNVKK CCCCCCCCCCCCCCC	65.17	-
213	Ubiquitination	HHGTEEPKQDTNVKK CCCCCCCCCCCCCCC	65.17	-
213	Sumoylation	HHGTEEPKQDTNVKK CCCCCCCCCCCCCCC	65.17	28112733
219	Sumoylation	PKQDTNVKKAKRPKP CCCCCCCCCCCCCCC	49.43	28112733
225	Sumoylation	VKKAKRPKPESQGIK CCCCCCCCCHHHCCC	66.50	-
225	Sumoylation	VKKAKRPKPESQGIK CCCCCCCCCHHHCCC	66.50	28112733
225	Ubiquitination	VKKAKRPKPESQGIK CCCCCCCCCHHHCCC	66.50	-
228	Phosphorylation	AKRPKPESQGIKAKR CCCCCCHHHCCCCCC	42.08	29083192
232	Sumoylation	KPESQGIKAKRKPSA CCHHHCCCCCCCCCC	55.47	-
232	Sumoylation	KPESQGIKAKRKPSA CCHHHCCCCCCCCCC	55.47	28112733
238	Phosphorylation	IKAKRKPSASSKPSL CCCCCCCCCCCCCCC	43.76	25627689
242	Acetylation	RKPSASSKPSLVGDG CCCCCCCCCCCCCCC	35.81	26051181
242	Sumoylation	RKPSASSKPSLVGDG CCCCCCCCCCCCCCC	35.81	28112733
244	Phosphorylation	PSASSKPSLVGDGEG CCCCCCCCCCCCCCC	39.15	25627689
255	Phosphorylation	DGEGAILSPSQKPHI CCCCCCCCCCCCCCC	19.18	25159151
257	Phosphorylation	EGAILSPSQKPHICD CCCCCCCCCCCCCCC	47.67	29052541
259	Sumoylation	AILSPSQKPHICDHC CCCCCCCCCCCCCCC	42.79	-
259	Sumoylation	AILSPSQKPHICDHC CCCCCCCCCCCCCCC	42.79	28112733
279	Ubiquitination	SSYHLRRHVLIHTGE HHHHHHCCEEEECCC	16.58	-
284	Phosphorylation	RRHVLIHTGERPFQC HCCEEEECCCCCCCC	33.47	27422710
292	Phosphorylation	GERPFQCSQCSMGFI CCCCCCCCCCCHHHH	24.36	28348404
293	Ubiquitination	ERPFQCSQCSMGFIQ CCCCCCCCCCHHHHH	30.82	-
301	Sumoylation	CSMGFIQKYLLQRHE CCHHHHHHHHHHHHH	32.80	28112733
307	Ubiquitination	QKYLLQRHEKIHSRE HHHHHHHHHHHHCCC	27.95	-
310	Ubiquitination	LLQRHEKIHSREKPF HHHHHHHHHCCCCCC	3.04	-
312	Phosphorylation	QRHEKIHSREKPFGC HHHHHHHCCCCCCCC	45.68	29214152
315	Ubiquitination	EKIHSREKPFGCDQC HHHHCCCCCCCCCHH	44.53	-
325	Sumoylation	GCDQCSMKFIQKYHM CCCHHHHHHHHHHHH	24.03	-
325	Sumoylation	GCDQCSMKFIQKYHM CCCHHHHHHHHHHHH	24.03	28112733
325	Ubiquitination	GCDQCSMKFIQKYHM CCCHHHHHHHHHHHH	24.03	-
329	Sumoylation	CSMKFIQKYHMERHK HHHHHHHHHHHHHHC	32.10	-
329	Ubiquitination	CSMKFIQKYHMERHK HHHHHHHHHHHHHHC	32.10	-
329	Sumoylation	CSMKFIQKYHMERHK HHHHHHHHHHHHHHC	32.10	-
337	Ubiquitination	YHMERHKRTHSGEKP HHHHHHCCCCCCCCC	31.39	-
340	Phosphorylation	ERHKRTHSGEKPYKC HHHCCCCCCCCCCCC	48.29	29214152
343	Ubiquitination	KRTHSGEKPYKCDTC CCCCCCCCCCCCCHH	58.11	-
343	Acetylation	KRTHSGEKPYKCDTC CCCCCCCCCCCCCHH	58.11	26051181
346	Sumoylation	HSGEKPYKCDTCQQY CCCCCCCCCCHHHHH	33.87	-
346	Ubiquitination	HSGEKPYKCDTCQQY CCCCCCCCCCHHHHH	33.87	-
346	Sumoylation	HSGEKPYKCDTCQQY CCCCCCCCCCHHHHH	33.87	-
353	Phosphorylation	KCDTCQQYFSRTDRL CCCHHHHHHHHHHHH	4.25	17360941
357	Phosphorylation	CQQYFSRTDRLLKHR HHHHHHHHHHHHHHH	25.03	28555341
373	Sumoylation	TCGEVIVKGATSAEP CCCCEEEECCCCCCC	31.53	-
373	Ubiquitination	TCGEVIVKGATSAEP CCCCEEEECCCCCCC	31.53	-
373	Sumoylation	TCGEVIVKGATSAEP CCCCEEEECCCCCCC	31.53	28112733
373	Ubiquitination	TCGEVIVKGATSAEP CCCCEEEECCCCCCC	31.53	-
380	Ubiquitination	KGATSAEPGSSNHTN ECCCCCCCCCCCCCC	47.91	-
382	O-linked_Glycosylation	ATSAEPGSSNHTNMG CCCCCCCCCCCCCCC	38.39	30059200
383	Ubiquitination	TSAEPGSSNHTNMGN CCCCCCCCCCCCCCC	38.25	-
395	Phosphorylation	MGNLAVLSQGNTSSS CCCEEEEECCCCCCC	29.46	17525332
399	Phosphorylation	AVLSQGNTSSSRRKT EEEECCCCCCCCCCC	36.49	25159151
400	Phosphorylation	VLSQGNTSSSRRKTK EEECCCCCCCCCCCC	30.25	25159151
401	Phosphorylation	LSQGNTSSSRRKTKS EECCCCCCCCCCCCC	26.31	26074081
402	Phosphorylation	SQGNTSSSRRKTKSK ECCCCCCCCCCCCCC	35.55	26074081
409	Sumoylation	SRRKTKSKSIAIENK CCCCCCCCCEEECCC	47.65	-
409	Ubiquitination	SRRKTKSKSIAIENK CCCCCCCCCEEECCC	47.65	-
409	Sumoylation	SRRKTKSKSIAIENK CCCCCCCCCEEECCC	47.65	28112733
410	Phosphorylation	RRKTKSKSIAIENKE CCCCCCCCEEECCCC	25.09	27251275
416	Sumoylation	KSIAIENKEQKTGKT CCEEECCCCHHCCCC	49.05	-
416	Ubiquitination	KSIAIENKEQKTGKT CCEEECCCCHHCCCC	49.05	-
416	Sumoylation	KSIAIENKEQKTGKT CCEEECCCCHHCCCC	49.05	28112733
416	Acetylation	KSIAIENKEQKTGKT CCEEECCCCHHCCCC	49.05	25953088
419	Ubiquitination	AIENKEQKTGKTNES EECCCCHHCCCCCHH	61.41	-
437	Ubiquitination	NNINMQSYSVEMPTV CCCCCCEEEEECCCC	10.39	-
438	Phosphorylation	NINMQSYSVEMPTVS CCCCCEEEEECCCCC	19.49	-
438	O-linked_Glycosylation	NINMQSYSVEMPTVS CCCCCEEEEECCCCC	19.49	OGP
441	Ubiquitination	MQSYSVEMPTVSSSG CCEEEEECCCCCCCC	2.94	-
443	O-linked_Glycosylation	SYSVEMPTVSSSGGI EEEEECCCCCCCCCC	31.54	30059200
445	Phosphorylation	SVEMPTVSSSGGIIG EEECCCCCCCCCCCC	22.67	-
445	O-linked_Glycosylation	SVEMPTVSSSGGIIG EEECCCCCCCCCCCC	22.67	30059200
446	Phosphorylation	VEMPTVSSSGGIIGT EECCCCCCCCCCCCC	28.76	-
447	O-linked_Glycosylation	EMPTVSSSGGIIGTG ECCCCCCCCCCCCCC	33.27	30059200
453	O-linked_Glycosylation	SSGGIIGTGIDELQK CCCCCCCCCHHHHHH	22.13	30059200
460	Sumoylation	TGIDELQKRVPKLIF CCHHHHHHHCCHHHH	68.90	28112733
462	Ubiquitination	IDELQKRVPKLIFKK HHHHHHHCCHHHHCC	6.72	-
464	Sumoylation	ELQKRVPKLIFKKGS HHHHHCCHHHHCCCC	51.89	-
464	Sumoylation	ELQKRVPKLIFKKGS HHHHHCCHHHHCCCC	51.89	-
477	Sumoylation	GSRKNTDKNYLNFVS CCCCCCCCCCCCCCC	45.51	-
477	Ubiquitination	GSRKNTDKNYLNFVS CCCCCCCCCCCCCCC	45.51	-
477	Sumoylation	GSRKNTDKNYLNFVS CCCCCCCCCCCCCCC	45.51	28112733
479	Phosphorylation	RKNTDKNYLNFVSPL CCCCCCCCCCCCCCC	14.57	17360941
484	Phosphorylation	KNYLNFVSPLPDIVG CCCCCCCCCCCCCCC	19.31	25159151
493	Sumoylation	LPDIVGQKSLSGKPS CCCCCCCCCCCCCCC	47.65	28112733
498	Sumoylation	GQKSLSGKPSGSLGI CCCCCCCCCCCCEEE	32.41	-
498	Ubiquitination	GQKSLSGKPSGSLGI CCCCCCCCCCCCEEE	32.41	-
498	Sumoylation	GQKSLSGKPSGSLGI CCCCCCCCCCCCEEE	32.41	28112733
498	Acetylation	GQKSLSGKPSGSLGI CCCCCCCCCCCCEEE	32.41	26051181
503	Ubiquitination	SGKPSGSLGIVSNNS CCCCCCCEEEEECCC	6.56	-
504	Ubiquitination	GKPSGSLGIVSNNSV CCCCCCEEEEECCCE	21.68	-
529	Phosphorylation	GKQGQISSNYDDAMQ CCCCCCCCCHHHHHH	40.83	-
531	Phosphorylation	QGQISSNYDDAMQFS CCCCCCCHHHHHHHH	19.69	-
538	Phosphorylation	YDDAMQFSKKRRYLP HHHHHHHHHHCCCCC	22.00	28555341
539	Sumoylation	DDAMQFSKKRRYLPT HHHHHHHHHCCCCCC	52.14	-
539	Ubiquitination	DDAMQFSKKRRYLPT HHHHHHHHHCCCCCC	52.14	21906983
539	Sumoylation	DDAMQFSKKRRYLPT HHHHHHHHHCCCCCC	52.14	28112733
563	Ubiquitination	NVGHMVSQQSVIQSA ECCCCCCHHHHHHHC	28.32	-
581	Ubiquitination	VLDNEAPLSLIDSSA EECCCCCHHHHCHHH	9.31	-
586	Ubiquitination	APLSLIDSSALNAEI CCHHHHCHHHHHHHH	15.54	-
595	Phosphorylation	ALNAEIKSCHDKSGI HHHHHHHHCHHCCCC	23.50	21712546
599	Ubiquitination	EIKSCHDKSGIPDEV HHHHCHHCCCCCHHH	27.24	-
599	Acetylation	EIKSCHDKSGIPDEV HHHHCHHCCCCCHHH	27.24	26051181
599	Sumoylation	EIKSCHDKSGIPDEV HHHHCHHCCCCCHHH	27.24	28112733
600	Phosphorylation	IKSCHDKSGIPDEVL HHHCHHCCCCCHHHH	48.27	22199227
615	Phosphorylation	QSILDQYSNKSESQK HHHHHHHCCCCHHCC	31.95	29507054
617	Ubiquitination	ILDQYSNKSESQKED HHHHHCCCCHHCCCC	50.05	-
617	Sumoylation	ILDQYSNKSESQKED HHHHHCCCCHHCCCC	50.05	28112733
618	Phosphorylation	LDQYSNKSESQKEDP HHHHCCCCHHCCCCC	46.89	30266825
620	Phosphorylation	QYSNKSESQKEDPFN HHCCCCHHCCCCCCC	54.35	30266825
622	Sumoylation	SNKSESQKEDPFNIA CCCCHHCCCCCCCCC	73.66	-
622	Ubiquitination	SNKSESQKEDPFNIA CCCCHHCCCCCCCCC	73.66	21906983
622	Sumoylation	SNKSESQKEDPFNIA CCCCHHCCCCCCCCC	73.66	28112733
625	Ubiquitination	SESQKEDPFNIAEPR CHHCCCCCCCCCCCC	25.85	-
634	Ubiquitination	NIAEPRVDLHTSGEH CCCCCCEECCCCCCC	33.73	-
637	Phosphorylation	EPRVDLHTSGEHSEL CCCEECCCCCCCHHH	45.80	23663014
638	Phosphorylation	PRVDLHTSGEHSELV CCEECCCCCCCHHHH	31.28	25159151
642	Phosphorylation	LHTSGEHSELVQEEN CCCCCCCHHHHHHCC	28.46	25159151
651	Phosphorylation	LVQEENLSPGTQTPS HHHHCCCCCCCCCCC	32.63	23401153
654	Phosphorylation	EENLSPGTQTPSNDK HCCCCCCCCCCCCHH	32.43	23401153
656	Phosphorylation	NLSPGTQTPSNDKAS CCCCCCCCCCCHHHH	28.64	25159151
658	Phosphorylation	SPGTQTPSNDKASML CCCCCCCCCHHHHHH	62.13	28102081
661	Ubiquitination	TQTPSNDKASMLQEY CCCCCCHHHHHHHHH	46.76	21906983
661	Sumoylation	TQTPSNDKASMLQEY CCCCCCHHHHHHHHH	46.76	28112733
670	Sumoylation	SMLQEYSKYLQQAFE HHHHHHHHHHHHHHH	49.42	-
670	Ubiquitination	SMLQEYSKYLQQAFE HHHHHHHHHHHHHHH	49.42	21906983
670	Sumoylation	SMLQEYSKYLQQAFE HHHHHHHHHHHHHHH	49.42	28112733
679	O-linked_Glycosylation	LQQAFEKSTNASFTL HHHHHHHCCCCEEEC	21.50	30059200
683	Phosphorylation	FEKSTNASFTLGHGF HHHCCCCEEECCCCE	22.34	25159151
685	O-linked_Glycosylation	KSTNASFTLGHGFQF HCCCCEEECCCCEEE	29.36	30059200
694	O-linked_Glycosylation	GHGFQFVSLSSPLHN CCCEEEEECCCCCCC	24.67	30059200
694	Phosphorylation	GHGFQFVSLSSPLHN CCCEEEEECCCCCCC	24.67	27174698
696	Phosphorylation	GFQFVSLSSPLHNHT CEEEEECCCCCCCCC	23.54	25159151
696	O-linked_Glycosylation	GFQFVSLSSPLHNHT CEEEEECCCCCCCCC	23.54	30059200
697	Phosphorylation	FQFVSLSSPLHNHTL EEEEECCCCCCCCCC	36.45	25159151
697	O-linked_Glycosylation	FQFVSLSSPLHNHTL EEEEECCCCCCCCCC	36.45	30059200
703	O-linked_Glycosylation	SSPLHNHTLFPEKQI CCCCCCCCCCCCCCE	35.10	30059200
713	O-linked_Glycosylation	PEKQIYTTSPLECGF CCCCEEECCCCCCCC	16.04	30059200
751	Acetylation	QPGLYLSALDATHQQ CCCEEHHHHHHHCCC	13.58	-
751	Ubiquitination	QPGLYLSALDATHQQ CCCEEHHHHHHHCCC	13.58	-
759	Ubiquitination	LDATHQQLTPSQELD HHHHCCCCCCCHHHH	6.47	-
777	Phosphorylation	DSQKNLETSSAFQSS HHHHHHHHHHHHHHH	31.02	23312004
778	Phosphorylation	SQKNLETSSAFQSSS HHHHHHHHHHHHHHH	15.42	30266825
778	O-linked_Glycosylation	SQKNLETSSAFQSSS HHHHHHHHHHHHHHH	15.42	30059200
779	Phosphorylation	QKNLETSSAFQSSSQ HHHHHHHHHHHHHHH	40.29	30266825
782	Ubiquitination	LETSSAFQSSSQKLT HHHHHHHHHHHHHHH	41.96	-
783	Phosphorylation	ETSSAFQSSSQKLTS HHHHHHHHHHHHHHC	26.04	30266825
784	Phosphorylation	TSSAFQSSSQKLTSQ HHHHHHHHHHHHHCH	26.46	30266825
785	Phosphorylation	SSAFQSSSQKLTSQK HHHHHHHHHHHHCHH	36.26	17525332
787	Sumoylation	AFQSSSQKLTSQKEQ HHHHHHHHHHCHHHH	56.53	-
787	Ubiquitination	AFQSSSQKLTSQKEQ HHHHHHHHHHCHHHH	56.53	21906983
787	Sumoylation	AFQSSSQKLTSQKEQ HHHHHHHHHHCHHHH	56.53	28112733
787	Acetylation	AFQSSSQKLTSQKEQ HHHHHHHHHHCHHHH	56.53	23236377
792	Acetylation	SQKLTSQKEQKNLES HHHHHCHHHHHCHHH	62.98	11922969
792	Sumoylation	SQKLTSQKEQKNLES HHHHHCHHHHHCHHH	62.98	28112733
795	Sumoylation	LTSQKEQKNLESSTG HHCHHHHHCHHHCCC	65.67	-
795	Ubiquitination	LTSQKEQKNLESSTG HHCHHHHHCHHHCCC	65.67	21906983
795	Sumoylation	LTSQKEQKNLESSTG HHCHHHHHCHHHCCC	65.67	28112733
799	Phosphorylation	KEQKNLESSTGFQIP HHHHCHHHCCCCCCC	36.04	23663014
800	Phosphorylation	EQKNLESSTGFQIPS HHHCHHHCCCCCCCH	24.15	23663014
801	Phosphorylation	QKNLESSTGFQIPSQ HHCHHHCCCCCCCHH	51.82	23663014
804	Ubiquitination	LESSTGFQIPSQELA HHHCCCCCCCHHHHH	48.29	-
807	Phosphorylation	STGFQIPSQELASQI CCCCCCCHHHHHHCC	37.61	17525332
812	Phosphorylation	IPSQELASQIDPQKD CCHHHHHHCCCCCCC	40.05	29214152
818	Ubiquitination	ASQIDPQKDIEPRTT HHCCCCCCCCCCCCE	67.09	-
818	Sumoylation	ASQIDPQKDIEPRTT HHCCCCCCCCCCCCE	67.09	28112733
837	Phosphorylation	NFAQAFGSQFKSGSR HHHHHHHHCCCCCCC	26.45	21712546
840	Sumoylation	QAFGSQFKSGSRVPM HHHHHCCCCCCCCCE	46.39	-
840	Ubiquitination	QAFGSQFKSGSRVPM HHHHHCCCCCCCCCE	46.39	2190698
840	Sumoylation	QAFGSQFKSGSRVPM HHHHHCCCCCCCCCE	46.39	28112733
841	Phosphorylation	AFGSQFKSGSRVPMT HHHHCCCCCCCCCEE	43.20	28555341
848	Phosphorylation	SGSRVPMTFITNSNG CCCCCCEEEEECCCC	13.05	20860994
851	Phosphorylation	RVPMTFITNSNGEVD CCCEEEEECCCCCEE	28.53	22210691
853	O-linked_Glycosylation	PMTFITNSNGEVDHR CEEEEECCCCCEEEE	37.25	30059200
853	Phosphorylation	PMTFITNSNGEVDHR CEEEEECCCCCEEEE	37.25	28555341
863	O-linked_Glycosylation	EVDHRVRTSVSDFSG CEEEEEECCHHHHCC	30.53	30059200
863	Phosphorylation	EVDHRVRTSVSDFSG CEEEEEECCHHHHCC	30.53	27251275
864	Phosphorylation	VDHRVRTSVSDFSGY EEEEEECCHHHHCCC	14.73	27251275
864	O-linked_Glycosylation	VDHRVRTSVSDFSGY EEEEEECCHHHHCCC	14.73	30059200
866	O-linked_Glycosylation	HRVRTSVSDFSGYTN EEEECCHHHHCCCCC	32.48	30059200
866	Phosphorylation	HRVRTSVSDFSGYTN EEEECCHHHHCCCCC	32.48	20860994
872	Phosphorylation	VSDFSGYTNMMSDVS HHHHCCCCCCCCCCC	21.84	-
876	Phosphorylation	SGYTNMMSDVSEPCS CCCCCCCCCCCCCCC	24.88	20860994
879	Phosphorylation	TNMMSDVSEPCSTRV CCCCCCCCCCCCCCC	40.59	30576142
883	Phosphorylation	SDVSEPCSTRVKTPT CCCCCCCCCCCCCCC	29.93	22210691
884	Phosphorylation	DVSEPCSTRVKTPTS CCCCCCCCCCCCCCC	46.31	30576142
887	Ubiquitination	EPCSTRVKTPTSQSY CCCCCCCCCCCCCCC	45.56	-
888	Phosphorylation	PCSTRVKTPTSQSYR CCCCCCCCCCCCCCC	29.01	25218447
890	Phosphorylation	STRVKTPTSQSYR-- CCCCCCCCCCCCC--	44.63	23403867
891	O-linked_Glycosylation	TRVKTPTSQSYR--- CCCCCCCCCCCC---	20.52	30059200
891	Phosphorylation	TRVKTPTSQSYR--- CCCCCCCCCCCC---	20.52	23403867
891	O-linked_Glycosylation	TRVKTPTSQSYR--- CCCCCCCCCCCC---	20.52	20068230
893	O-linked_Glycosylation	VKTPTSQSYR----- CCCCCCCCCC-----	23.73	30059200
893	Phosphorylation	VKTPTSQSYR----- CCCCCCCCCC-----	23.73	23403867
894	Phosphorylation	KTPTSQSYR------ CCCCCCCCC------	16.83	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
638	S	Phosphorylation	Kinase	GSK3B	P49841	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN281_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN281_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NANOG_HUMAN	NANOG	physical	18757296
PO5F1_HUMAN	POU5F1	physical	18757296
SOX2_HUMAN	SOX2	physical	18757296
PRCC_HUMAN	PRCC	physical	26496610
TAP2_HUMAN	TAP2	physical	26496610
KCAB2_HUMAN	KCNAB2	physical	26496610
GOGA5_HUMAN	GOLGA5	physical	26496610
MAGD2_HUMAN	MAGED2	physical	26496610
KI21B_HUMAN	KIF21B	physical	26496610
MILK2_HUMAN	MICALL2	physical	26496610
WDCP_HUMAN	C2orf44	physical	26496610
ZN644_HUMAN	ZNF644	physical	26496610
GRIN1_HUMAN	GPRIN1	physical	26496610
OSBL5_HUMAN	OSBPL5	physical	26496610
MLKL_HUMAN	MLKL	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN281_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395; SER-785 ANDSER-807, AND MASS SPECTROMETRY.	17525332 [Abstract]