dbPTM

NANOG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NANOG_HUMAN
UniProt AC	Q9H9S0
Protein Name	Homeobox protein NANOG
Gene Name	NANOG
Organism	Homo sapiens (Human).
Sequence Length	305
Subcellular Localization	Nucleus .
Protein Description	Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. [PubMed: 25825768 Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.]
Protein Sequence	MSVDPACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAEKSVAKKEDKVPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQGCLVNPTGNLPMWSNQTWNNSTWSNQTQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEESLQSCMQFQPNSPASDLEAALEAAGEGLNVIQQTTRYFSTPQTMDLFLNYSMNMQPEDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	ICGPEENYPSLQMSS EECCHHCCCCCCCCC	9.47	22493428
50	Phosphorylation	AEMPHTETVSPLPSS CCCCCCCCCCCCCCH	27.69	-
52	Phosphorylation	MPHTETVSPLPSSMD CCCCCCCCCCCCHHC	28.30	-
56	Phosphorylation	ETVSPLPSSMDLLIQ CCCCCCCCHHCEEEE	46.08	-
57	Phosphorylation	TVSPLPSSMDLLIQD CCCCCCCHHCEEEEC	17.86	-
65	Phosphorylation	MDLLIQDSPDSSTSP HCEEEECCCCCCCCC	17.77	-
68	Phosphorylation	LIQDSPDSSTSPKGK EEECCCCCCCCCCCC	38.61	-
69	Phosphorylation	IQDSPDSSTSPKGKQ EECCCCCCCCCCCCC	40.04	26546556
70	Phosphorylation	QDSPDSSTSPKGKQP ECCCCCCCCCCCCCC	53.66	-
71	Phosphorylation	DSPDSSTSPKGKQPT CCCCCCCCCCCCCCC	26.94	26546556
78	Phosphorylation	SPKGKQPTSAEKSVA CCCCCCCCCHHHHHC	37.77	-
79	Phosphorylation	PKGKQPTSAEKSVAK CCCCCCCCHHHHHCC	40.91	-
119	Phosphorylation	DRFQRQKYLSLQQMQ HHHHHHHHCCHHHHH	7.99	27067055
121	Phosphorylation	FQRQKYLSLQQMQEL HHHHHHCCHHHHHHH	22.50	27067055
129	Phosphorylation	LQQMQELSNILNLSY HHHHHHHHHHHCCCH	22.52	27067055
135	Phosphorylation	LSNILNLSYKQVKTW HHHHHCCCHHHHHHH	29.25	27067055
174	Phosphorylation	QKASAPTYPSLYSSY CCCCCCCCHHHHHHC	6.97	22493428
200	Phosphorylation	LPMWSNQTWNNSTWS CCCCCCCCCCCCCCC	34.12	-
258	Phosphorylation	CMQFQPNSPASDLEA HHCCCCCCCHHHHHH	28.64	-
280	Phosphorylation	GLNVIQQTTRYFSTP HHHHHHHHCCCCCCC	9.25	-
286	Phosphorylation	QTTRYFSTPQTMDLF HHCCCCCCCHHHHHH	14.98	-
289	Phosphorylation	RYFSTPQTMDLFLNY CCCCCCHHHHHHHHH	17.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
35	Y	Phosphorylation	Kinase	PTK2	Q05397	GPS
52	S	Phosphorylation	Kinase	ERK2	P28482	PSP
65	S	Phosphorylation	Kinase	CDK1	P06493	PSP
65	S	Phosphorylation	Kinase	ERK2	P28482	PSP
68	S	Phosphorylation	Kinase	BRAF	P15056	PSP
71	S	Phosphorylation	Kinase	CDK1	P06493	PSP
78	T	Phosphorylation	Kinase	PRKCE	Q02156	GPS
79	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
135	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
174	Y	Phosphorylation	Kinase	PTK2	Q05397	GPS
200	T	Phosphorylation	Kinase	PRKCE	Q02156	GPS
280	T	Phosphorylation	Kinase	PRKCE	Q02156	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:31624231:30595538

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NANOG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NANOG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED12_HUMAN	MED12	physical	19036726
RHXF2_HUMAN	RHOXF2	physical	20211142
DOT1L_HUMAN	DOT1L	genetic	22388813
NANOG_HUMAN	NANOG	physical	23708658
ACACB_HUMAN	ACACB	physical	26687479
ACOT9_HUMAN	ACOT9	physical	26687479
AKP8L_HUMAN	AKAP8L	physical	26687479
AKAP9_HUMAN	AKAP9	physical	26687479
THOC4_HUMAN	ALYREF	physical	26687479
AMZ2_HUMAN	AMZ2	physical	26687479
APC4_HUMAN	ANAPC4	physical	26687479
ANGE2_HUMAN	ANGEL2	physical	26687479
ARGL1_HUMAN	ARGLU1	physical	26687479
ARI1B_HUMAN	ARID1B	physical	26687479
ARI3A_HUMAN	ARID3A	physical	26687479
ARI3B_HUMAN	ARID3B	physical	26687479
BAG2_HUMAN	BAG2	physical	26687479
TREF1_HUMAN	TRERF1	physical	26687479
BCLF1_HUMAN	BCLAF1	physical	26687479
K1551_HUMAN	KIAA1551	physical	26687479
CFA20_HUMAN	CFAP20	physical	26687479
RTCB_HUMAN	RTCB	physical	26687479
CBX2_HUMAN	CBX2	physical	26687479
CCD86_HUMAN	CCDC86	physical	26687479
CDAN1_HUMAN	CDAN1	physical	26687479
CDC73_HUMAN	CDC73	physical	26687479
CDKA1_HUMAN	CDK2AP1	physical	26687479
CECR2_HUMAN	CECR2	physical	26687479
HDHD5_HUMAN	CECR5	physical	26687479
CENPF_HUMAN	CENPF	physical	26687479
COF2_HUMAN	CFL2	physical	26687479
CHERP_HUMAN	CHERP	physical	26687479
CIRBP_HUMAN	CIRBP	physical	26687479
CLIP1_HUMAN	CLIP1	physical	26687479
CRBN_HUMAN	CRBN	physical	26687479
CSK21_HUMAN	CSNK2A1	physical	26687479
CUL4A_HUMAN	CUL4A	physical	26687479
DDB1_HUMAN	DDB1	physical	26687479
DDX20_HUMAN	DDX20	physical	26687479
DDX24_HUMAN	DDX24	physical	26687479
DHC24_HUMAN	DHCR24	physical	26687479
DNJA3_HUMAN	DNAJA3	physical	26687479
TDIF1_HUMAN	DNTTIP1	physical	26687479
DPY30_HUMAN	DPY30	physical	26687479
ECM29_HUMAN	KIAA0368	physical	26687479
EDF1_HUMAN	EDF1	physical	26687479
EIF3D_HUMAN	EIF3D	physical	26687479
ELP3_HUMAN	ELP3	physical	26687479
NEP1_HUMAN	EMG1	physical	26687479
EP400_HUMAN	EP400	physical	26687479
ERBB3_HUMAN	ERBB3	physical	26687479
RB6I2_HUMAN	ERC1	physical	26687479
ERCC8_HUMAN	ERCC8	physical	26687479
EXOSX_HUMAN	EXOSC10	physical	26687479
FA60A_HUMAN	FAM60A	physical	26687479
FBX11_HUMAN	FBXO11	physical	26687479
GANAB_HUMAN	GANAB	physical	26687479
GT251_HUMAN	COLGALT1	physical	26687479
GPTC8_HUMAN	GPATCH8	physical	26687479
GPS2_HUMAN	GPS2	physical	26687479
HASP_HUMAN	GSG2	physical	26687479
TF3C3_HUMAN	GTF3C3	physical	26687479
TF3C4_HUMAN	GTF3C4	physical	26687479
HDX_HUMAN	HDX	physical	26687479
HLTF_HUMAN	HLTF	physical	26687479
HMGA1_HUMAN	HMGA1	physical	26687479
HNRH2_HUMAN	HNRNPH2	physical	26687479
HNRL2_HUMAN	HNRNPUL2	physical	26687479
HNRDL_HUMAN	HNRNPDL	physical	26687479
HRG_HUMAN	HRG	physical	26687479
HSP7C_HUMAN	HSPA8	physical	26687479
GRP75_HUMAN	HSPA9	physical	26687479
HUWE1_HUMAN	HUWE1	physical	26687479
IBTK_HUMAN	IBTK	physical	26687479
ILF2_HUMAN	ILF2	physical	26687479
ING1_HUMAN	ING1	physical	26687479
ING2_HUMAN	ING2	physical	26687479
IPO8_HUMAN	IPO8	physical	26687479
ITPR3_HUMAN	ITPR3	physical	26687479
JARD2_HUMAN	JARID2	physical	26687479
KDM2B_HUMAN	KDM2B	physical	26687479
FUBP2_HUMAN	KHSRP	physical	26687479
CCAR2_HUMAN	CCAR2	physical	26687479
KI20B_HUMAN	KIF20B	physical	26687479
MAN1_HUMAN	LEMD3	physical	26687479
LTMD1_HUMAN	LETMD1	physical	26687479
LUC7L_HUMAN	LUC7L	physical	26687479
MAGD1_HUMAN	MAGED1	physical	26687479
MBD3_HUMAN	MBD3	physical	26687479
MCCB_HUMAN	MCCC2	physical	26687479
MCM2_HUMAN	MCM2	physical	26687479
MLF2_HUMAN	MLF2	physical	26687479
MRE11_HUMAN	MRE11A	physical	26687479
RM37_HUMAN	MRPL37	physical	26687479
RM49_HUMAN	MRPL49	physical	26687479
RM09_HUMAN	MRPL9	physical	26687479
RT31_HUMAN	MRPS31	physical	26687479
RT35_HUMAN	MRPS35	physical	26687479
RT06_HUMAN	MRPS6	physical	26687479
MTA1_HUMAN	MTA1	physical	26687479
MTA2_HUMAN	MTA2	physical	26687479
MTA3_HUMAN	MTA3	physical	26687479
MUC16_HUMAN	MUC16	physical	26687479
MUTYH_HUMAN	MUTYH	physical	26687479
NAA50_HUMAN	NAA50	physical	26687479
NBN_HUMAN	NBN	physical	26687479
CND1_HUMAN	NCAPD2	physical	26687479
CNDD3_HUMAN	NCAPD3	physical	26687479
NCOR2_HUMAN	NCOR2	physical	26687479
NDUS3_HUMAN	NDUFS3	physical	26687479
NOP58_HUMAN	NOP58	physical	26687479
NSF_HUMAN	NSF	physical	26687479
OTX2_HUMAN	OTX2	physical	26687479
GLD2_HUMAN	PAPD4	physical	26687479
PAXI1_HUMAN	PAXIP1	physical	26687479
PB1_HUMAN	PBRM1	physical	26687479
PCD15_HUMAN	PCDH15	physical	26687479
PCGF1_HUMAN	PCGF1	physical	26687479
PCGF2_HUMAN	PCGF2	physical	26687479
PIMT_HUMAN	PCMT1	physical	26687479
PCMD1_HUMAN	PCMTD1	physical	26687479
PCMD2_HUMAN	PCMTD2	physical	26687479
PDCD7_HUMAN	PDCD7	physical	26687479
PDE6A_HUMAN	PDE6A	physical	26687479
PDPR_HUMAN	PDPR	physical	26687479
PEG10_HUMAN	PEG10	physical	26687479
PHC1_HUMAN	PHC1	physical	26687479
PPOX_HUMAN	PPOX	physical	26687479
P2R3A_HUMAN	PPP2R3A	physical	26687479
2A5E_HUMAN	PPP2R5E	physical	26687479
PRAM_HUMAN	PRAM1	physical	26687479
PRC1_HUMAN	PRC1	physical	26687479
PRD14_HUMAN	PRDM14	physical	26687479
PR38B_HUMAN	PRPF38B	physical	26687479
PSMD2_HUMAN	PSMD2	physical	26687479
PTCD3_HUMAN	PTCD3	physical	26687479
PTN12_HUMAN	PTPN12	physical	26687479
RAB13_HUMAN	RAB13	physical	26687479
RD23B_HUMAN	RAD23B	physical	26687479
RAD52_HUMAN	RAD52	physical	26687479
RBCC1_HUMAN	RB1CC1	physical	26687479
RBBP5_HUMAN	RBBP5	physical	26687479
SPF45_HUMAN	RBM17	physical	26687479
RBM4_HUMAN	RBM4	physical	26687479
RING2_HUMAN	RNF2	physical	26687479
RPE_HUMAN	RPE	physical	26687479
RL38_HUMAN	RPL38	physical	26687479
RRP12_HUMAN	RRP12	physical	26687479
RUNX3_HUMAN	RUNX3	physical	26687479
SALL1_HUMAN	SALL1	physical	26687479
SALL2_HUMAN	SALL2	physical	26687479
SALL3_HUMAN	SALL3	physical	26687479
SALL4_HUMAN	SALL4	physical	26687479
SMAG2_HUMAN	SAMD4B	physical	26687479
SP130_HUMAN	SAP130	physical	26687479
SAS6_HUMAN	SASS6	physical	26687479
SATB2_HUMAN	SATB2	physical	26687479
SCAFB_HUMAN	SCAF11	physical	26687479
SIN3A_HUMAN	SIN3A	physical	26687479
SI1L2_HUMAN	SIPA1L2	physical	26687479
SMAD4_HUMAN	SMAD4	physical	26687479
SMCA1_HUMAN	SMARCA1	physical	26687479
SMC3_HUMAN	SMC3	physical	26687479
RSMB_HUMAN	SNRPB	physical	26687479
SOX2_HUMAN	SOX2	physical	26687479
SOX21_HUMAN	SOX21	physical	26687479
CYTSB_HUMAN	SPECC1	physical	26687479
SPOP_HUMAN	SPOP	physical	26687479
SSBP3_HUMAN	SSBP3	physical	26687479
SUGP1_HUMAN	SUGP1	physical	26687479
SP16H_HUMAN	SUPT16H	physical	26687479
SUZ12_HUMAN	SUZ12	physical	26687479
SYF2_HUMAN	SYF2	physical	26687479
TBL1X_HUMAN	TBL1X	physical	26687479
ELOC_HUMAN	TCEB1	physical	26687479
TCF20_HUMAN	TCF20	physical	26687479
ITF2_HUMAN	TCF4	physical	26687479
TF7L1_HUMAN	TCF7L1	physical	26687479
TEAD2_HUMAN	TEAD2	physical	26687479
TFB2M_HUMAN	TFB2M	physical	26687479
TIA1_HUMAN	TIA1	physical	26687479
TIAR_HUMAN	TIAL1	physical	26687479
TOR3A_HUMAN	TOR3A	physical	26687479
TP53B_HUMAN	TP53BP1	physical	26687479
TPIS_HUMAN	TPI1	physical	26687479
TPP2_HUMAN	TPP2	physical	26687479
TPPC5_HUMAN	TRAPPC5	physical	26687479
RO52_HUMAN	TRIM21	physical	26687479
TIF1A_HUMAN	TRIM24	physical	26687479
TRI33_HUMAN	TRIM33	physical	26687479
TRM6_HUMAN	TRMT6	physical	26687479
TRM61_HUMAN	TRMT61A	physical	26687479
TRPM1_HUMAN	TRPM1	physical	26687479
TBA1A_HUMAN	TUBA1A	physical	26687479
TBB5_HUMAN	TUBB	physical	26687479
GCP3_HUMAN	TUBGCP3	physical	26687479
TWF2_HUMAN	TWF2	physical	26687479
THIO_HUMAN	TXN	physical	26687479
TXN4A_HUMAN	TXNL4A	physical	26687479
UBP34_HUMAN	USP34	physical	26687479
UBP42_HUMAN	USP42	physical	26687479
UBP7_HUMAN	USP7	physical	26687479
USP9X_HUMAN	USP9X	physical	26687479
VRTN_HUMAN	VRTN	physical	26687479
WT1_HUMAN	WT1	physical	26687479
XRCC5_HUMAN	XRCC5	physical	26687479
YETS2_HUMAN	YEATS2	physical	26687479
ZCHC3_HUMAN	ZCCHC3	physical	26687479
ZGPAT_HUMAN	ZGPAT	physical	26687479
ZIC2_HUMAN	ZIC2	physical	26687479
ZIC3_HUMAN	ZIC3	physical	26687479
ZMIZ1_HUMAN	ZMIZ1	physical	26687479
ZN157_HUMAN	ZNF157	physical	26687479
ZN281_HUMAN	ZNF281	physical	26687479
ZN467_HUMAN	ZNF467	physical	26687479
ZN524_HUMAN	ZNF524	physical	26687479
ZN609_HUMAN	ZNF609	physical	26687479
ZN865_HUMAN	ZNF865	physical	26687479
H32_HUMAN	HIST2H3C	physical	26687479
UBP21_HUMAN	USP21	physical	27886188
UBP21_HUMAN	USP21	physical	27956178

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NANOG_HUMAN

Related Literatures of Post-Translational Modification