MUTYH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MUTYH_HUMAN
• UniProt AC: Q9UIF7
• Protein Name: Adenine DNA glycosylase
• Gene Name: MUTYH
• Organism: Homo sapiens (Human).
• Sequence Length: 546
• Subcellular Localization: Nucleus . Mitochondrion .
• Protein Description: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities..
• Protein Sequence: MTPLVSRLSRLWAIMRKPRAAVGSGHRKQAASQEGRQKHAKNNSQAKPSACDGMIAECPGAPAGLARQPEEVVLQASVSSYHLFRDVAEVTAFRGSLLSWYDQEKRDLPWRRRAEDEMDLDRRAYAVWVSEVMLQQTQVATVINYYTGWMQKWPTLQDLASASLEEVNQLWAGLGYYSRGRRLQEGARKVVEELGGHMPRTAETLQQLLPGVGRYTAGAIASIAFGQATGVVDGNVARVLCRVRAIGADPSSTLVSQQLWGLAQQLVDPARPGDFNQAAMELGATVCTPQRPLCSQCPVESLCRARQRVEQEQLLASGSLSGSPDVEECAPNTGQCHLCLPPSEPWDQTLGVVNFPRKASRKPPREESSATCVLEQPGALGAQILLVQRPNSGLLAGLWEFPSVTWEPSEQLQRKALLQELQRWAGPLPATHLRHLGEVVHTFSHIKLTYQVYGLALEGQTPVTTVPPGARWLTQEEFHTAAVSTAMKKVFRVYQGQQPGTCMGSKRSQVSSPCSRKKPRMGQQVLDNFFRSHISTDAHSLNSAAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTPLVSRLS ------CCHHHHHHH	25.90	29083192
6	Phosphorylation	--MTPLVSRLSRLWA --CCHHHHHHHHHHH	34.88	26552605
9	Phosphorylation	TPLVSRLSRLWAIMR CHHHHHHHHHHHHHC	24.98	27422710
24	Phosphorylation	KPRAAVGSGHRKQAA CCCCCCCCCHHHHHH	25.48	-
28 (in isoform 1)	Ubiquitination	-	38.32	22053931
28	Ubiquitination	AVGSGHRKQAASQEG CCCCCHHHHHHHHHH	38.32	22053931
41 (in isoform 3)	Ubiquitination	-	57.28	-
47 (in isoform 3)	Ubiquitination	-	31.69	-
94 (in isoform 3)	Ubiquitination	-	31.18	-
105	Ubiquitination	LSWYDQEKRDLPWRR HHHHCHHCCCCCCHH	45.65	-
178 (in isoform 3)	Ubiquitination	-	21.56	-
189	Ubiquitination	RLQEGARKVVEELGG HHHHHHHHHHHHHCC	50.53	-
360	Phosphorylation	VNFPRKASRKPPREE CCCCCCCCCCCCCCC	43.82	22817900
404 (in isoform 3)	Ubiquitination	-	8.00	-
415	Ubiquitination	PSEQLQRKALLQELQ CCHHHHHHHHHHHHH	30.35	-
494	Phosphorylation	MKKVFRVYQGQQPGT HHHHHHHHCCCCCCC	11.58	29978859
495 (in isoform 3)	Ubiquitination	-	40.12	-
501	Phosphorylation	YQGQQPGTCMGSKRS HCCCCCCCCCCCCCC	13.15	29978859
505	Phosphorylation	QPGTCMGSKRSQVSS CCCCCCCCCCCCCCC	9.67	29978859
506	Ubiquitination	PGTCMGSKRSQVSSP CCCCCCCCCCCCCCC	50.79	-
508	Phosphorylation	TCMGSKRSQVSSPCS CCCCCCCCCCCCCCC	38.37	28102081
511	Phosphorylation	GSKRSQVSSPCSRKK CCCCCCCCCCCCCCC	22.41	26552605
512	Phosphorylation	SKRSQVSSPCSRKKP CCCCCCCCCCCCCCC	30.94	26552605
515	Phosphorylation	SQVSSPCSRKKPRMG CCCCCCCCCCCCCHH	50.98	26552605
535	Phosphorylation	NFFRSHISTDAHSLN HHHHHHHCCCHHHHH	18.14	22817900
540	Phosphorylation	HISTDAHSLNSAAQ- HHCCCHHHHHHHCC-	30.85	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	HUWE1	Q7Z6Z7	PMID:24443563

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MUTYH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MUTYH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APEX1_HUMAN	APEX1	physical	11092888
PCNA_HUMAN	PCNA	physical	11092888
RFA1_HUMAN	RPA1	physical	11092888
MSH2_HUMAN	MSH2	physical	11801590
MSH6_HUMAN	MSH6	physical	11801590
APEX1_HUMAN	APEX1	physical	24209961
HUWE1_HUMAN	HUWE1	physical	24443563
ATRAP_HUMAN	AGTRAP	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608456: Familial adenomatous polyposis 2 (FAP2)
• 613659: Gastric cancer (GASC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.