SP130_HUMAN - dbPTM
SP130_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SP130_HUMAN
UniProt AC Q9H0E3
Protein Name Histone deacetylase complex subunit SAP130
Gene Name SAP130
Organism Homo sapiens (Human).
Sequence Length 1048
Subcellular Localization Nucleus .
Protein Description Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes..
Protein Sequence MGPPRHPQAGEIEAGGAGGGRRLQVEMSSQQFPRLGAPSTGLSQAPSQIANSGSAGLINPAATVNDESGRDSEVSAREHMSSSSSLQSREEKQEPVVVRPYPQVQMLSTHHAVASATPVAVTAPPAHLTPAVPLSFSEGLMKPPPKPTMPSRPIAPAPPSTLSLPPKVPGQVTVTMESSIPQASAIPVATISGQQGHPSNLHHIMTTNVQMSIIRSNAPGPPLHIGASHLPRGAAAAAVMSSSKVTTVLRPTSQLPNAATAQPAVQHIIHQPIQSRPPVTTSNAIPPAVVATVSATRAQSPVITTTAAHATDSALSRPTLSIQHPPSAAISIQRPAQSRDVTTRITLPSHPALGTPKQQLHTMAQKTIFSTGTPVAAATVAPILATNTIPSATTAGSVSHTQAPTSTIVTMTVPSHSSHATAVTTSNIPVAKVVPQQITHTSPRIQPDYPAERSSLIPISGHRASPNPVAMETRSDNRPSVPVQFQYFLPTYPPSAYPLAAHTYTPITSSVSTIRQYPVSAQAPNSAITAQTGVGVASTVHLNPMQLMTVDASHARHIQGIQPAPISTQGIQPAPIGTPGIQPAPLGTQGIHSATPINTQGLQPAPMGTQQPQPEGKTSAVVLADGATIVANPISNPFSAAPAATTVVQTHSQSASTNAPAQGSSPRPSILRKKPATDGAKPKSEIHVSMATPVTVSMETVSNQNNDQPTIAVPPTAQQPPPTIPTMIAAASPPSQPAVALSTIPGAVPITPPITTIAAAPPPSVTVGGSLSSVLGPPVPEIKVKEEVEPMDIMRPVSAVPPLATNTVSPSLALLANNLSMPTSDLPPGASPRKKPRKQQHVISTEEGDMMETNSTDDEKSTAKSLLVKAEKRKSPPKEYIDEEGVRYVPVRPRPPITLLRHYRNPWKAAYHHFQRYSDVRVKEEKKAMLQEIANQKGVSCRAQGWKVHLCAAQLLQLTNLEHDVYERLTNLQEGIIPKKKAATDDDLHRINELIQGNMQRCKLVMDQISEARDSMLKVLDHKDRVLKLLNKNGTVKKVSKLKRKEKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Methylation---MGPPRHPQAGEI
---CCCCCCCCCCCE		58.20115493277
29PhosphorylationRLQVEMSSQQFPRLG
EEEEEECCCCCCCCC		27.0422798277
34MethylationMSSQQFPRLGAPSTG
ECCCCCCCCCCCCCC		47.22115388623
63PhosphorylationGLINPAATVNDESGR
CCCCCCCCCCCCCCC		23.19-
72PhosphorylationNDESGRDSEVSAREH
CCCCCCCCHHHHHHH		38.24-
75PhosphorylationSGRDSEVSAREHMSS
CCCCCHHHHHHHHCC		19.9828985074
83PhosphorylationAREHMSSSSSLQSRE
HHHHHCCCHHHCCHH		19.3528985074
108O-linked_GlycosylationYPQVQMLSTHHAVAS
CCCCEECCCCCCHHC		21.9830059200
122O-linked_GlycosylationSATPVAVTAPPAHLT
CCCCEEEECCCCCCC		24.5730059200
129O-linked_GlycosylationTAPPAHLTPAVPLSF
ECCCCCCCCCCCCCC		10.1930059200
148PhosphorylationMKPPPKPTMPSRPIA
CCCCCCCCCCCCCCC		48.0829449344
151PhosphorylationPPKPTMPSRPIAPAP
CCCCCCCCCCCCCCC		39.6129449344
226 (in isoform 2)Phosphorylation-15.4121815630
232MethylationIGASHLPRGAAAAAV
ECCCCCCHHHHHHHH		54.4624129315
235 (in isoform 2)Phosphorylation-10.6428176443
236 (in isoform 2)Phosphorylation-8.7428176443
237 (in isoform 2)Phosphorylation-8.8925849741
239 (in isoform 2)Phosphorylation-3.0726055452
300PhosphorylationVSATRAQSPVITTTA
ECCCCCCCCEEEEEC		21.8329255136
304PhosphorylationRAQSPVITTTAAHAT
CCCCCEEEEECCHHC		20.5130108239
305O-linked_GlycosylationAQSPVITTTAAHATD
CCCCEEEEECCHHCC		11.8730059200
305PhosphorylationAQSPVITTTAAHATD
CCCCEEEEECCHHCC		11.8730108239
306O-linked_GlycosylationQSPVITTTAAHATDS
CCCEEEEECCHHCCC		17.1330059200
306PhosphorylationQSPVITTTAAHATDS
CCCEEEEECCHHCCC		17.1330108239
311PhosphorylationTTTAAHATDSALSRP
EEECCHHCCCHHCCC		22.1827251275
313PhosphorylationTAAHATDSALSRPTL
ECCHHCCCHHCCCEE		27.1027251275
316PhosphorylationHATDSALSRPTLSIQ
HHCCCHHCCCEEECC		35.6127251275
319PhosphorylationDSALSRPTLSIQHPP
CCHHCCCEEECCCCC		31.8427251275
321PhosphorylationALSRPTLSIQHPPSA
HHCCCEEECCCCCCC		23.7627251275
327O-linked_GlycosylationLSIQHPPSAAISIQR
EECCCCCCCEEEEEC		34.4830059200
331O-linked_GlycosylationHPPSAAISIQRPAQS
CCCCCEEEEECCCCC		14.1430059200
344MethylationQSRDVTTRITLPSHP
CCCCCCCEEECCCCC		15.55115493269
346O-linked_GlycosylationRDVTTRITLPSHPAL
CCCCCEEECCCCCCC		29.3530059200
346PhosphorylationRDVTTRITLPSHPAL
CCCCCEEECCCCCCC		29.3527251275
349O-linked_GlycosylationTTRITLPSHPALGTP
CCEEECCCCCCCCCC		45.2630059200
349PhosphorylationTTRITLPSHPALGTP
CCEEECCCCCCCCCC		45.2620068231
355PhosphorylationPSHPALGTPKQQLHT
CCCCCCCCCHHHHHH		28.3221712546
439PhosphorylationKVVPQQITHTSPRIQ
EECCCCCCCCCCCCC		18.1123927012
441PhosphorylationVPQQITHTSPRIQPD
CCCCCCCCCCCCCCC		31.6030266825
442PhosphorylationPQQITHTSPRIQPDY
CCCCCCCCCCCCCCC		12.4630266825
444MethylationQITHTSPRIQPDYPA
CCCCCCCCCCCCCCC		39.68115493289
453MethylationQPDYPAERSSLIPIS
CCCCCCHHCCCCCCC		33.3880702559
454PhosphorylationPDYPAERSSLIPISG
CCCCCHHCCCCCCCC		22.4723927012
455PhosphorylationDYPAERSSLIPISGH
CCCCHHCCCCCCCCC		36.2223927012
460O-linked_GlycosylationRSSLIPISGHRASPN
HCCCCCCCCCCCCCC		24.1630059200
460PhosphorylationRSSLIPISGHRASPN
HCCCCCCCCCCCCCC		24.1623927012
463MethylationLIPISGHRASPNPVA
CCCCCCCCCCCCCEE		40.04115493281
465PhosphorylationPISGHRASPNPVAME
CCCCCCCCCCCEEEE		25.7623401153
471SulfoxidationASPNPVAMETRSDNR
CCCCCEEEEECCCCC		5.7121406390
473PhosphorylationPNPVAMETRSDNRPS
CCCEEEEECCCCCCC		23.5323927012
480O-linked_GlycosylationTRSDNRPSVPVQFQY
ECCCCCCCCCEEEEE		35.5030059200
491O-linked_GlycosylationQFQYFLPTYPPSAYP
EEEEECCCCCCCCCC		51.3030059200
495O-linked_GlycosylationFLPTYPPSAYPLAAH
ECCCCCCCCCCCCCE		35.6130059200
503O-linked_GlycosylationAYPLAAHTYTPITSS
CCCCCCEECCCCCCC		25.1030059200
505O-linked_GlycosylationPLAAHTYTPITSSVS
CCCCEECCCCCCCCC		14.9030059200
508O-linked_GlycosylationAHTYTPITSSVSTIR
CEECCCCCCCCCCHH		19.0230059200
509O-linked_GlycosylationHTYTPITSSVSTIRQ
EECCCCCCCCCCHHC		29.4830059200
510O-linked_GlycosylationTYTPITSSVSTIRQY
ECCCCCCCCCCHHCC		16.0730059200
512O-linked_GlycosylationTPITSSVSTIRQYPV
CCCCCCCCCHHCCCC		21.7730059200
513O-linked_GlycosylationPITSSVSTIRQYPVS
CCCCCCCCHHCCCCC		20.3030059200
635O-linked_GlycosylationTIVANPISNPFSAAP
EEEECCCCCCCCCCC		39.4430059200
639O-linked_GlycosylationNPISNPFSAAPAATT
CCCCCCCCCCCCCEE		25.4430059200
646O-linked_GlycosylationSAAPAATTVVQTHSQ
CCCCCCEEEEEECCC		17.6030059200
650PhosphorylationAATTVVQTHSQSAST
CCEEEEEECCCCCCC		16.3428348404
652PhosphorylationTTVVQTHSQSASTNA
EEEEEECCCCCCCCC		29.2628348404
654PhosphorylationVVQTHSQSASTNAPA
EEEECCCCCCCCCCC		27.4828348404
656PhosphorylationQTHSQSASTNAPAQG
EECCCCCCCCCCCCC		27.6928348404
657O-linked_GlycosylationTHSQSASTNAPAQGS
ECCCCCCCCCCCCCC		34.8130059200
657PhosphorylationTHSQSASTNAPAQGS
ECCCCCCCCCCCCCC		34.8128348404
664PhosphorylationTNAPAQGSSPRPSIL
CCCCCCCCCCCCHHH		25.7028348404
665PhosphorylationNAPAQGSSPRPSILR
CCCCCCCCCCCHHHC		31.5828348404
677PhosphorylationILRKKPATDGAKPKS
HHCCCCCCCCCCCCC		43.42-
696 (in isoform 3)Phosphorylation-5.3721815630
705 (in isoform 3)Phosphorylation-59.2928176443
706 (in isoform 3)Phosphorylation-39.2628176443
707 (in isoform 3)Phosphorylation-64.4825849741
709 (in isoform 3)Phosphorylation-28.7426055452
783SumoylationGPPVPEIKVKEEVEP
CCCCCCCEECCCCCC		45.66-
785SumoylationPVPEIKVKEEVEPMD
CCCCCEECCCCCCCC		43.06-
785SumoylationPVPEIKVKEEVEPMD
CCCCCEECCCCCCCC		43.0628112733
798PhosphorylationMDIMRPVSAVPPLAT
CCCCCCCCCCCCCCC		26.6520068231
805PhosphorylationSAVPPLATNTVSPSL
CCCCCCCCCCCCHHH		38.8220068231
807PhosphorylationVPPLATNTVSPSLAL
CCCCCCCCCCHHHHH		20.2920068231
809PhosphorylationPLATNTVSPSLALLA
CCCCCCCCHHHHHHH		13.5120068231
811PhosphorylationATNTVSPSLALLANN
CCCCCCHHHHHHHCC		20.8320068231
820PhosphorylationALLANNLSMPTSDLP
HHHHCCCCCCCCCCC		25.4920068231
823PhosphorylationANNLSMPTSDLPPGA
HCCCCCCCCCCCCCC		26.6520068231
824PhosphorylationNNLSMPTSDLPPGAS
CCCCCCCCCCCCCCC		31.1420068231
831PhosphorylationSDLPPGASPRKKPRK
CCCCCCCCCCCCCCC		31.0220068231
844PhosphorylationRKQQHVISTEEGDMM
CCCCCEEECCCCCCC		28.7823663014
845PhosphorylationKQQHVISTEEGDMME
CCCCEEECCCCCCCC		27.2523927012
853PhosphorylationEEGDMMETNSTDDEK
CCCCCCCCCCCCCHH		19.3023927012
855PhosphorylationGDMMETNSTDDEKST
CCCCCCCCCCCHHHH		40.4023927012
856PhosphorylationDMMETNSTDDEKSTA
CCCCCCCCCCHHHHH		49.9223927012
861PhosphorylationNSTDDEKSTAKSLLV
CCCCCHHHHHHHHHH		31.3923927012
862PhosphorylationSTDDEKSTAKSLLVK
CCCCHHHHHHHHHHH		49.5325219547
864SumoylationDDEKSTAKSLLVKAE
CCHHHHHHHHHHHHH		41.5528112733
865PhosphorylationDEKSTAKSLLVKAEK
CHHHHHHHHHHHHHH		25.1926074081
869SumoylationTAKSLLVKAEKRKSP
HHHHHHHHHHHCCCC		51.28-
869AcetylationTAKSLLVKAEKRKSP
HHHHHHHHHHHCCCC		51.2825953088
869MethylationTAKSLLVKAEKRKSP
HHHHHHHHHHHCCCC		51.28-
869SumoylationTAKSLLVKAEKRKSP
HHHHHHHHHHHCCCC		51.2828112733
875PhosphorylationVKAEKRKSPPKEYID
HHHHHCCCCCHHHCC		50.9323401153
880PhosphorylationRKSPPKEYIDEEGVR
CCCCCHHHCCCCCCE		21.5730576142
937UbiquitinationLQEIANQKGVSCRAQ
HHHHHHCCCCCHHHC		62.17-
972 (in isoform 3)Ubiquitination-4.06-
979UbiquitinationLQEGIIPKKKAATDD
CCCCCCCCCCCCCHH		57.40-
981UbiquitinationEGIIPKKKAATDDDL
CCCCCCCCCCCHHHH		49.75-
999SulfoxidationNELIQGNMQRCKLVM
HHHHHHHHHHHHHHH		3.2121406390
10232-HydroxyisobutyrylationMLKVLDHKDRVLKLL
HHHHHCHHHHHHHHH		47.07-
1023UbiquitinationMLKVLDHKDRVLKLL
HHHHHCHHHHHHHHH		47.07-
1028UbiquitinationDHKDRVLKLLNKNGT
CHHHHHHHHHCCCCC		48.33-
1040PhosphorylationNGTVKKVSKLKRKEK
CCCCCHHHHHCCHHC		40.9425599653
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SP130_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SP130_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SP130_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIN3A_HUMANSIN3Aphysical
12724404
HDAC1_HUMANHDAC1physical
12724404
HDAC2_HUMANHDAC2physical
12724404
SDS3_HUMANSUDS3physical
12724404
CUL2_HUMANCUL2physical
18173839
SF3B1_HUMANSF3B1physical
18173839
CUL1_HUMANCUL1physical
18173839
CUL4A_HUMANCUL4Aphysical
18173839
VHL_HUMANVHLphysical
18173839
ELOB_HUMANTCEB2physical
18173839
TAF10_HUMANTAF10physical
22939629
CUL4B_HUMANCUL4Bphysical
25189618
DDB1_HUMANDDB1physical
25189618
SIN3A_HUMANSIN3Aphysical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SP130_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-355; SER-442 ANDSER-875, AND MASS SPECTROMETRY.
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-454 AND SER-455, ANDMASS SPECTROMETRY.

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