dbPTM

ZN609_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN609_HUMAN
UniProt AC	O15014
Protein Name	Zinc finger protein 609 {ECO:0000312\|HGNC:HGNC:29003}
Gene Name	ZNF609 {ECO:0000312\|HGNC:HGNC:29003}
Organism	Homo sapiens (Human).
Sequence Length	1411
Subcellular Localization	Isoform 2: Nucleus .
Protein Description	Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.; Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis..
Protein Sequence	MSLSSGASGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDTSKPTPGTSLFTPSEGAASKKEVQGRSGDGANAGGLVAAIAPKGSEKAAKASRSVAGSKKEKENSSSKSKKERSEGVGTCSEKDPGVLQPVPLGGRGGQYDGSAGVDTGAVEPLGSIAIEPGAALNPLGTKPEPEEGENECRLLKKVKSEKMESPVSTPAVLPIHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPNSNTPVNETATASDSKGTSNSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKNKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTVLDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPILHADLGSCNGASVSQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDLGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKPEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTATVAQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKESSKELESPLTPGKVCRAEEGKSPFRESSGDGMKMEGLLNGSSDPHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLENTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSVKSKDAEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPSYAQSSPGALNPSSQAGVESQALKTKRDEEPESIEGKVKNDICEEKKPELSSSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHTHLLSTNTAYRQQYEEQQKRQSLEQQQRGVDKKAEMGLKEREAALKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGADPAKSVIIPKLDDSSKLPGQAPEGLKVKLSDASHLSKEASEAKTGAECGRQAEMDPILWYRQEAEPRMWTYVYPAKYSDIKSEDERWKEERDRKLKEERSRSKDSVPKEDGKESTSSDCKLPTSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRSMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVTCKSSSESKALDILQQHASHYKSKSPTISDKTSQERDRGGCGVVGGGGSCSSVGGASGGERSVDRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSLSSGASGGKGVDA CCCCCCCCCCCCCCC	52.16	25159151
23	Phosphorylation	NPVETYDSGDEWDIG CCCCCCCCCCCEEEC	37.42	28192239
52	Phosphorylation	DQQKLEMSGSKEVGI HHHHHHHCCCCCCCC	30.46	27251275
76	Phosphorylation	PDNIKFVTPVPGPQG CCCEEEEECCCCCCC	23.00	25159151
84	Acetylation	PVPGPQGKEGKSKSK CCCCCCCCCCCCCCC	59.03	25953088
93	Phosphorylation	GKSKSKRSKSGKDTS CCCCCCCCCCCCCCC	34.60	26074081
94	Ubiquitination	KSKSKRSKSGKDTSK CCCCCCCCCCCCCCC	68.23	25015289
95	Phosphorylation	SKSKRSKSGKDTSKP CCCCCCCCCCCCCCC	52.93	26074081
97	Acetylation	SKRSKSGKDTSKPTP CCCCCCCCCCCCCCC	65.99	12433305
97	Ubiquitination	SKRSKSGKDTSKPTP CCCCCCCCCCCCCCC	65.99	25015289
99	Phosphorylation	RSKSGKDTSKPTPGT CCCCCCCCCCCCCCC	41.98	26074081
100	Phosphorylation	SKSGKDTSKPTPGTS CCCCCCCCCCCCCCC	46.93	26074081
101	Acetylation	KSGKDTSKPTPGTSL CCCCCCCCCCCCCCC	55.81	12433315
101	Ubiquitination	KSGKDTSKPTPGTSL CCCCCCCCCCCCCCC	55.81	25015289
103	Phosphorylation	GKDTSKPTPGTSLFT CCCCCCCCCCCCCCC	37.78	26074081
106	Phosphorylation	TSKPTPGTSLFTPSE CCCCCCCCCCCCCCC	24.38	26074081
107	Phosphorylation	SKPTPGTSLFTPSEG CCCCCCCCCCCCCCC	27.66	26074081
110	Phosphorylation	TPGTSLFTPSEGAAS CCCCCCCCCCCCCCC	31.06	26074081
112	Phosphorylation	GTSLFTPSEGAASKK CCCCCCCCCCCCCCC	45.67	26074081
117	Phosphorylation	TPSEGAASKKEVQGR CCCCCCCCCCCCCCC	43.67	26074081
118	Acetylation	PSEGAASKKEVQGRS CCCCCCCCCCCCCCC	48.50	25953088
118	Ubiquitination	PSEGAASKKEVQGRS CCCCCCCCCCCCCCC	48.50	25015289
125	Phosphorylation	KKEVQGRSGDGANAG CCCCCCCCCCCCCCC	48.32	20068231
143	Phosphorylation	AAIAPKGSEKAAKAS EEECCCCCHHHHHHH	41.89	27282143
160	Ubiquitination	VAGSKKEKENSSSKS HCCCHHHHCCCCCCC	71.69	24816145
163	Phosphorylation	SKKEKENSSSKSKKE CHHHHCCCCCCCHHH	36.76	-
164	Phosphorylation	KKEKENSSSKSKKER HHHHCCCCCCCHHHH	54.06	-
165	Phosphorylation	KEKENSSSKSKKERS HHHCCCCCCCHHHHH	40.55	-
167	Phosphorylation	KENSSSKSKKERSEG HCCCCCCCHHHHHCC	51.40	23911959
181	Acetylation	GVGTCSEKDPGVLQP CCCCCCCCCCCCCCC	53.59	25953088
252	Phosphorylation	VKSEKMESPVSTPAV HCHHCCCCCCCCCCE	27.40	25159151
255	Phosphorylation	EKMESPVSTPAVLPI HCCCCCCCCCCEEEE	31.86	28450419
256	Phosphorylation	KMESPVSTPAVLPIH CCCCCCCCCCEEEEE	18.59	28450419
274	Phosphorylation	PVVNNDISSPCEQIM EECCCCCCCHHHHHH	30.96	24043423
275	Phosphorylation	VVNNDISSPCEQIMV ECCCCCCCHHHHHHH	33.62	24043423
284	Phosphorylation	CEQIMVRTRSVGVNT HHHHHHHHCCCCCCC	18.84	24043423
338	Phosphorylation	VTWRNKTYVGTLLDC EEECCCEEEEEHHCC	9.86	-
358	Phosphorylation	APPRFCDSPTSDLEM CCCCCCCCCCCCCCC	31.12	29255136
360	Phosphorylation	PRFCDSPTSDLEMRN CCCCCCCCCCCCCCC	38.53	22167270
361	Phosphorylation	RFCDSPTSDLEMRNG CCCCCCCCCCCCCCC	43.51	22167270
379	Phosphorylation	GKRMRPNSNTPVNET CCCCCCCCCCCCCCC	44.77	29255136
381	Phosphorylation	RMRPNSNTPVNETAT CCCCCCCCCCCCCCC	28.56	29255136
386	Phosphorylation	SNTPVNETATASDSK CCCCCCCCCCCCCCC	24.89	25850435
388	Phosphorylation	TPVNETATASDSKGT CCCCCCCCCCCCCCC	33.83	25850435
390	Phosphorylation	VNETATASDSKGTSN CCCCCCCCCCCCCCC	37.75	25850435
392	Phosphorylation	ETATASDSKGTSNSS CCCCCCCCCCCCCCC	30.41	29396449
395	Phosphorylation	TASDSKGTSNSSKTR CCCCCCCCCCCCCCC	28.59	22210691
396	Phosphorylation	ASDSKGTSNSSKTRA CCCCCCCCCCCCCCC	43.30	25002506
398	Phosphorylation	DSKGTSNSSKTRAGA CCCCCCCCCCCCCCC	32.74	25002506
399	Phosphorylation	SKGTSNSSKTRAGAN CCCCCCCCCCCCCCC	42.15	25002506
401	Phosphorylation	GTSNSSKTRAGANSK CCCCCCCCCCCCCCC	27.92	22210691
413	Phosphorylation	NSKGRRGSQNSSEHR CCCCCCCCCCCCCCC	25.11	23401153
416	Phosphorylation	GRRGSQNSSEHRPPA CCCCCCCCCCCCCCC	29.48	29255136
417	Phosphorylation	RRGSQNSSEHRPPAS CCCCCCCCCCCCCCC	45.00	29255136
424	Phosphorylation	SEHRPPASSTSEDVK CCCCCCCCCCCHHHH	39.66	30206219
425	Phosphorylation	EHRPPASSTSEDVKA CCCCCCCCCCHHHHC	37.75	29255136
426	Phosphorylation	HRPPASSTSEDVKAS CCCCCCCCCHHHHCC	33.37	29255136
427	Phosphorylation	RPPASSTSEDVKASP CCCCCCCCHHHHCCC	33.47	29255136
433	Phosphorylation	TSEDVKASPSSANKR CCHHHHCCCCCCCCC	21.43	26055452
435	Phosphorylation	EDVKASPSSANKRKN HHHHCCCCCCCCCCC	39.32	23403867
436	Phosphorylation	DVKASPSSANKRKNK HHHCCCCCCCCCCCC	38.96	23403867
446	Phosphorylation	KRKNKPLSDMELNSS CCCCCCCCCCCCCCC	43.36	25159151
452	Phosphorylation	LSDMELNSSSEDSKG CCCCCCCCCCCCCCC	48.11	30266825
453	Phosphorylation	SDMELNSSSEDSKGS CCCCCCCCCCCCCCC	36.35	30266825
454	Phosphorylation	DMELNSSSEDSKGSK CCCCCCCCCCCCCCC	45.29	30266825
457	Phosphorylation	LNSSSEDSKGSKRVR CCCCCCCCCCCCCCC	34.56	28450419
460	Phosphorylation	SSEDSKGSKRVRTNS CCCCCCCCCCCCCCC	22.48	26074081
465	Phosphorylation	KGSKRVRTNSMGSAT CCCCCCCCCCCCCCC	28.87	29255136
467	Phosphorylation	SKRVRTNSMGSATGP CCCCCCCCCCCCCCC	24.73	29255136
470	Phosphorylation	VRTNSMGSATGPLPG CCCCCCCCCCCCCCC	17.64	30266825
472	Phosphorylation	TNSMGSATGPLPGTK CCCCCCCCCCCCCCC	40.82	23927012
478	Phosphorylation	ATGPLPGTKVEPTVL CCCCCCCCCCCCCEE	29.94	23927012
479	Sumoylation	TGPLPGTKVEPTVLD CCCCCCCCCCCCEEC	50.98	28112733
483	Phosphorylation	PGTKVEPTVLDRNCP CCCCCCCCEECCCCC	21.86	23403867
491	Phosphorylation	VLDRNCPSPVLIDCP EECCCCCCCEEECCC	29.82	23927012
514	Phosphorylation	KHINGLKYHQAHAHT CCCCCCCCEEECCCC	12.28	24144214
521	Phosphorylation	YHQAHAHTDDDSKPE CEEECCCCCCCCCCC	41.74	24144214
525	Phosphorylation	HAHTDDDSKPEADGD CCCCCCCCCCCCCCC	58.04	24144214
533	Phosphorylation	KPEADGDSEYGEEPI CCCCCCCCCCCCCCC	37.94	28348404
535	Phosphorylation	EADGDSEYGEEPILH CCCCCCCCCCCCCEE	33.51	24144214
547	Phosphorylation	ILHADLGSCNGASVS CEEEECCCCCCCCCC	16.23	24144214
552	Phosphorylation	LGSCNGASVSQKGSL CCCCCCCCCCCCCCC	24.57	24144214
554	Phosphorylation	SCNGASVSQKGSLSP CCCCCCCCCCCCCCC	24.55	24144214
558	Phosphorylation	ASVSQKGSLSPARSA CCCCCCCCCCCCCCC	32.48	22617229
560	Phosphorylation	VSQKGSLSPARSATP CCCCCCCCCCCCCCC	20.43	30266825
564	Phosphorylation	GSLSPARSATPKVRL CCCCCCCCCCCCEEE	38.30	25159151
566	Phosphorylation	LSPARSATPKVRLVE CCCCCCCCCCEEEEC	25.53	25159151
568	Acetylation	PARSATPKVRLVEPH CCCCCCCCEEEECCC	35.32	7468549
576	Phosphorylation	VRLVEPHSPSPSSKF EEEECCCCCCCCCCC	37.48	19664994
578	Phosphorylation	LVEPHSPSPSSKFST EECCCCCCCCCCCCC	40.19	19664994
580	Phosphorylation	EPHSPSPSSKFSTKG CCCCCCCCCCCCCCC	50.96	29255136
581	Phosphorylation	PHSPSPSSKFSTKGL CCCCCCCCCCCCCCC	40.90	22167270
584	Phosphorylation	PSPSSKFSTKGLCKK CCCCCCCCCCCCCCC	32.71	21712546
585	Phosphorylation	SPSSKFSTKGLCKKK CCCCCCCCCCCCCCC	32.06	21712546
594	Phosphorylation	GLCKKKLSGEGDTDL CCCCCCCCCCCCCCH	43.61	21406692
599	Phosphorylation	KLSGEGDTDLGALSN CCCCCCCCCHHHCCC	43.94	30108239
605	Phosphorylation	DTDLGALSNDGSDDG CCCHHHCCCCCCCCC	32.13	23898821
609	Phosphorylation	GALSNDGSDDGPSVM HHCCCCCCCCCCCCC	35.08	23898821
614	Phosphorylation	DGSDDGPSVMDETSN CCCCCCCCCCCCCCC	35.29	30576142
619	Phosphorylation	GPSVMDETSNDAFDS CCCCCCCCCCHHHHH	28.68	25159151
620	Phosphorylation	PSVMDETSNDAFDSL CCCCCCCCCHHHHHH	30.57	25159151
626	Phosphorylation	TSNDAFDSLERKCME CCCHHHHHHHHHHHH	26.19	30576142
650	Phosphorylation	LKPEKIPSKSLKSAR CCCCCCCCCCCCCCC	38.05	24719451
651	Acetylation	KPEKIPSKSLKSARP CCCCCCCCCCCCCCC	55.22	25953088
669	Phosphorylation	AIPPQQIYTFQTATF CCCHHHEEEEEEEEE	9.36	24043423
670	Phosphorylation	IPPQQIYTFQTATFT CCHHHEEEEEEEEEE	15.76	23401153
673	Phosphorylation	QQIYTFQTATFTAAS HHEEEEEEEEEEECC	24.39	23401153
675	Phosphorylation	IYTFQTATFTAASPG EEEEEEEEEEECCCC	25.55	23401153
677	Phosphorylation	TFQTATFTAASPGSS EEEEEEEEECCCCCC	19.57	23401153
680	Phosphorylation	TATFTAASPGSSSGL EEEEEECCCCCCCCC	27.59	24043423
683	Phosphorylation	FTAASPGSSSGLTAT EEECCCCCCCCCHHH	25.39	24043423
684	Phosphorylation	TAASPGSSSGLTATV EECCCCCCCCCHHHH	34.05	24043423
685	Phosphorylation	AASPGSSSGLTATVA ECCCCCCCCCHHHHH	39.25	24043423
688	Phosphorylation	PGSSSGLTATVAQAM CCCCCCCHHHHHHHC	24.65	26074081
690	Phosphorylation	SSSGLTATVAQAMPN CCCCCHHHHHHHCCC	15.90	26074081
698	Phosphorylation	VAQAMPNSPQLKPIQ HHHHCCCCCCCCCCC	14.25	26074081
709	Phosphorylation	KPIQPKPTVMGEPFT CCCCCCCCCCCCCCC	29.29	20068231
716	Phosphorylation	TVMGEPFTVNPALTP CCCCCCCCCCCCCCC	30.04	28634298
722	Phosphorylation	FTVNPALTPAKDKKK CCCCCCCCCCCCCCC	24.25	29255136
737	Phosphorylation	KDKKKKESSKELESP CHHCHHHCHHHHCCC	56.44	26552605
738	Phosphorylation	DKKKKESSKELESPL HHCHHHCHHHHCCCC	31.10	26552605
743	Phosphorylation	ESSKELESPLTPGKV HCHHHHCCCCCCCCC	37.52	22167270
746	Phosphorylation	KELESPLTPGKVCRA HHHCCCCCCCCCEEC	33.12	19664994
749	Acetylation	ESPLTPGKVCRAEEG CCCCCCCCCEECCCC	39.09	25953088
758	Phosphorylation	CRAEEGKSPFRESSG EECCCCCCCCCCCCC	39.88	29255136
763	Phosphorylation	GKSPFRESSGDGMKM CCCCCCCCCCCCCEE	35.05	23927012
764	Phosphorylation	KSPFRESSGDGMKME CCCCCCCCCCCCEEE	35.83	23927012
777	Phosphorylation	MEGLLNGSSDPHQSR EECHHCCCCCHHHHH	30.41	25627689
778	Phosphorylation	EGLLNGSSDPHQSRL ECHHCCCCCHHHHHH	57.47	25159151
783	Phosphorylation	GSSDPHQSRLASIKA CCCCHHHHHHHHHHH	26.65	22817900
787	Phosphorylation	PHQSRLASIKAEADK HHHHHHHHHHHHHCE	29.25	28555341
789	Sumoylation	QSRLASIKAEADKIY HHHHHHHHHHHCEEE	37.36	-
789	Sumoylation	QSRLASIKAEADKIY HHHHHHHHHHHCEEE	37.36	28112733
794	Acetylation	SIKAEADKIYSFTDN HHHHHHCEEEEECCC	51.06	23236377
796	Phosphorylation	KAEADKIYSFTDNAP HHHHCEEEEECCCCC	11.95	21945579
797	Phosphorylation	AEADKIYSFTDNAPS HHHCEEEEECCCCCC	25.74	21945579
799	Phosphorylation	ADKIYSFTDNAPSPS HCEEEEECCCCCCCC	23.54	21945579
804	Phosphorylation	SFTDNAPSPSIGGSS EECCCCCCCCCCCCC	28.95	29255136
806	Phosphorylation	TDNAPSPSIGGSSRL CCCCCCCCCCCCCCC	37.90	21945579
810	Phosphorylation	PSPSIGGSSRLENTT CCCCCCCCCCCCCCC	13.68	21945579
811	Phosphorylation	SPSIGGSSRLENTTP CCCCCCCCCCCCCCC	44.13	21945579
816	Phosphorylation	GSSRLENTTPTQPLT CCCCCCCCCCCCCCC	25.44	22617229
817	Phosphorylation	SSRLENTTPTQPLTP CCCCCCCCCCCCCCC	35.60	25159151
819	Phosphorylation	RLENTTPTQPLTPLH CCCCCCCCCCCCCEE	40.50	21712546
823	Phosphorylation	TTPTQPLTPLHVVTQ CCCCCCCCCEEEEEC	30.41	27273156
829	Phosphorylation	LTPLHVVTQNGAEAS CCCEEEEECCCCCCC	18.41	28450419
836	Phosphorylation	TQNGAEASSVKTNSP ECCCCCCCCCCCCCC	27.46	28450419
837	Phosphorylation	QNGAEASSVKTNSPA CCCCCCCCCCCCCCC	34.38	28450419
840	Phosphorylation	AEASSVKTNSPAYSD CCCCCCCCCCCCCCC	38.48	25159151
842	Phosphorylation	ASSVKTNSPAYSDIS CCCCCCCCCCCCCCC	19.01	25159151
845	Phosphorylation	VKTNSPAYSDISDAG CCCCCCCCCCCCCCC	15.40	21955146
846	Phosphorylation	KTNSPAYSDISDAGE CCCCCCCCCCCCCCC	30.49	25159151
849	Phosphorylation	SPAYSDISDAGEDGE CCCCCCCCCCCCCCC	26.80	25159151
861	Phosphorylation	DGEGKVDSVKSKDAE CCCCCCCCCCCCCHH	34.14	23663014
886	Phosphorylation	LFPPQPQSKDSPYYQ CCCCCCCCCCCCCCC	45.15	-
889	Phosphorylation	PQPQSKDSPYYQGFE CCCCCCCCCCCCCCH	20.66	27732954
891	Phosphorylation	PQSKDSPYYQGFESY CCCCCCCCCCCCHHC	16.63	27732954
892	Phosphorylation	QSKDSPYYQGFESYY CCCCCCCCCCCHHCC	12.92	27732954
897	Phosphorylation	PYYQGFESYYSPSYA CCCCCCHHCCCCHHH	27.40	27732954
898	Phosphorylation	YYQGFESYYSPSYAQ CCCCCHHCCCCHHHC	10.77	27732954
899	Phosphorylation	YQGFESYYSPSYAQS CCCCHHCCCCHHHCC	24.31	22199227
900	Phosphorylation	QGFESYYSPSYAQSS CCCHHCCCCHHHCCC	10.11	22199227
902	Phosphorylation	FESYYSPSYAQSSPG CHHCCCCHHHCCCCC	27.45	22199227
903	Phosphorylation	ESYYSPSYAQSSPGA HHCCCCHHHCCCCCC	16.43	22199227
906	Phosphorylation	YSPSYAQSSPGALNP CCCHHHCCCCCCCCH	30.26	30576142
907	Phosphorylation	SPSYAQSSPGALNPS CCHHHCCCCCCCCHH	18.44	30576142
914	Phosphorylation	SPGALNPSSQAGVES CCCCCCHHHHCCHHH	33.73	22199227
915	Phosphorylation	PGALNPSSQAGVESQ CCCCCHHHHCCHHHH	25.88	22199227
921	Phosphorylation	SSQAGVESQALKTKR HHHCCHHHHHHCCCC	20.53	27732954
927	Ubiquitination	ESQALKTKRDEEPES HHHHHCCCCCCCCCC	57.15	-
1010	Ubiquitination	QQYEEQQKRQSLEQQ HHHHHHHHHHHHHHH	52.69	24816145
1013	Phosphorylation	EEQQKRQSLEQQQRG HHHHHHHHHHHHHHH	37.60	-
1024	Ubiquitination	QQRGVDKKAEMGLKE HHHHHHHHHHHHHHH	45.15	24816145
1030	Ubiquitination	KKAEMGLKEREAALK HHHHHHHHHHHHHHH	49.33	29967540
1037	Sumoylation	KEREAALKEEWKQKP HHHHHHHHHHHHCCC	49.19	-
1037	Sumoylation	KEREAALKEEWKQKP HHHHHHHHHHHHCCC	49.19	-
1037	Ubiquitination	KEREAALKEEWKQKP HHHHHHHHHHHHCCC	49.19	29967540
1045	Phosphorylation	EEWKQKPSIPPTLTK HHHHCCCCCCCCCCC	55.55	26074081
1049	Phosphorylation	QKPSIPPTLTKAPSL CCCCCCCCCCCCCCH	41.53	26074081
1051	Phosphorylation	PSIPPTLTKAPSLTD CCCCCCCCCCCCHHH	27.86	26074081
1055	Phosphorylation	PTLTKAPSLTDLVKS CCCCCCCCHHHHHHC	49.08	19664994
1057	Phosphorylation	LTKAPSLTDLVKSGP CCCCCCHHHHHHCCC	31.46	30266825
1061	Sumoylation	PSLTDLVKSGPGKAK CCHHHHHHCCCCCCC	57.92	28112733
1077	Phosphorylation	PGADPAKSVIIPKLD CCCCCCCEEEEECCC	22.21	20068231
1086	Phosphorylation	IIPKLDDSSKLPGQA EEECCCCCCCCCCCC	29.10	25278378
1087	Phosphorylation	IPKLDDSSKLPGQAP EECCCCCCCCCCCCC	45.25	27282143
1098	Ubiquitination	GQAPEGLKVKLSDAS CCCCCCEEEEEHHHH	48.45	29967540
1100	Ubiquitination	APEGLKVKLSDASHL CCCCEEEEEHHHHHH	40.46	29967540
1102	Phosphorylation	EGLKVKLSDASHLSK CCEEEEEHHHHHHCH	25.97	22210691
1105	Phosphorylation	KVKLSDASHLSKEAS EEEEHHHHHHCHHHH	29.92	22210691
1115	Sumoylation	SKEASEAKTGAECGR CHHHHHHHCHHCHHC	43.36	-
1115	Sumoylation	SKEASEAKTGAECGR CHHHHHHHCHHCHHC	43.36	-
1139	Dimethylation	YRQEAEPRMWTYVYP EECCCCCCCEEEEEE	25.44	-
1139	Methylation	YRQEAEPRMWTYVYP EECCCCCCCEEEEEE	25.44	115372867
1143	Phosphorylation	AEPRMWTYVYPAKYS CCCCCEEEEEECCHH	5.18	27642862
1148	Ubiquitination	WTYVYPAKYSDIKSE EEEEEECCHHHCCCH	40.56	23000965
1153	Sumoylation	PAKYSDIKSEDERWK ECCHHHCCCHHHHHH	53.43	-
1153	Sumoylation	PAKYSDIKSEDERWK ECCHHHCCCHHHHHH	53.43	28112733
1153	Ubiquitination	PAKYSDIKSEDERWK ECCHHHCCCHHHHHH	53.43	23000965
1172	Phosphorylation	RKLKEERSRSKDSVP HHHHHHHHCCCCCCC	44.15	26074081
1174	Phosphorylation	LKEERSRSKDSVPKE HHHHHHCCCCCCCCC	41.90	26074081
1177	Phosphorylation	ERSRSKDSVPKEDGK HHHCCCCCCCCCCCC	44.02	26074081
1195	O-linked_Glycosylation	SSDCKLPTSEESRLG CCCCCCCCCHHHCCC	60.24	30059200
1196	O-linked_Glycosylation	SDCKLPTSEESRLGS CCCCCCCCHHHCCCC	37.11	30059200
1196	O-linked_Glycosylation	SDCKLPTSEESRLGS CCCCCCCCHHHCCCC	37.11	20068230
1199	O-linked_Glycosylation	KLPTSEESRLGSKEP CCCCCHHHCCCCCCC	28.84	30059200
1215	Phosphorylation	PSVHVPVSSPLTQHQ CCCCCCCCCCCCCCC	21.84	25627689
1216	Phosphorylation	SVHVPVSSPLTQHQS CCCCCCCCCCCCCCC	24.94	25627689
1243	Phosphorylation	SYDPNHPSYRSMPAV CCCCCCCCHHCCCCE	26.15	20068231
1244	Phosphorylation	YDPNHPSYRSMPAVM CCCCCCCHHCCCCEE	15.91	20068231
1246	Phosphorylation	PNHPSYRSMPAVMMQ CCCCCHHCCCCEECC	22.38	30576142
1255	Phosphorylation	PAVMMQNYPGSYLPS CCEECCCCCCCCCCC	7.65	20068231
1258	Phosphorylation	MMQNYPGSYLPSSYS ECCCCCCCCCCCCCE	20.99	20068231
1259	Phosphorylation	MQNYPGSYLPSSYSF CCCCCCCCCCCCCEE	28.66	20068231
1262	Phosphorylation	YPGSYLPSSYSFSPY CCCCCCCCCCEECCC	39.03	20068231
1263	Phosphorylation	PGSYLPSSYSFSPYG CCCCCCCCCEECCCC	23.90	20068231
1264	Phosphorylation	GSYLPSSYSFSPYGS CCCCCCCCEECCCCC	20.33	30576142
1265	Phosphorylation	SYLPSSYSFSPYGSK CCCCCCCEECCCCCC	22.61	20068231
1267	Phosphorylation	LPSSYSFSPYGSKVS CCCCCEECCCCCCCC	15.98	20068231
1269	Phosphorylation	SSYSFSPYGSKVSGG CCCEECCCCCCCCCC	32.60	20068231
1271	Phosphorylation	YSFSPYGSKVSGGED CEECCCCCCCCCCCC	24.84	30576142
1274	Phosphorylation	SPYGSKVSGGEDADK CCCCCCCCCCCCHHH	44.83	26552605
1285	Phosphorylation	DADKARASPSVTCKS CHHHHHCCCCCEECC	16.50	25159151
1287	Phosphorylation	DKARASPSVTCKSSS HHHHCCCCCEECCCC	27.80	23403867
1289	Phosphorylation	ARASPSVTCKSSSES HHCCCCCEECCCCHH	20.67	23403867
1297	Sumoylation	CKSSSESKALDILQQ ECCCCHHHHHHHHHH	49.25	28112733
1297	Ubiquitination	CKSSSESKALDILQQ ECCCCHHHHHHHHHH	49.25	29967540
1310	Ubiquitination	QQHASHYKSKSPTIS HHHHHHHHCCCCCCC	46.08	29967540
1311	Phosphorylation	QHASHYKSKSPTISD HHHHHHHCCCCCCCC	31.06	23927012
1313	Phosphorylation	ASHYKSKSPTISDKT HHHHHCCCCCCCCCC	34.07	23401153
1315	Phosphorylation	HYKSKSPTISDKTSQ HHHCCCCCCCCCCCC	39.96	23927012
1317	Phosphorylation	KSKSPTISDKTSQER HCCCCCCCCCCCCCC	35.22	23403867
1320	Phosphorylation	SPTISDKTSQERDRG CCCCCCCCCCCCCCC	40.40	28111955
1321	Phosphorylation	PTISDKTSQERDRGG CCCCCCCCCCCCCCC	35.47	23312004
1339	Phosphorylation	VGGGGSCSSVGGASG CCCCCCCCCCCCCCC	29.74	28555341
1345	Phosphorylation	CSSVGGASGGERSVD CCCCCCCCCCCCCCC	51.08	28555341
1350	Phosphorylation	GASGGERSVDRPRTS CCCCCCCCCCCCCCC	24.86	28555341
1356	Phosphorylation	RSVDRPRTSPSQRLM CCCCCCCCCHHHHHH	47.90	24245541
1357	Phosphorylation	SVDRPRTSPSQRLMS CCCCCCCCHHHHHHH	24.67	27067055
1359	Phosphorylation	DRPRTSPSQRLMSTH CCCCCCHHHHHHHCC	27.92	28102081
1410	Methylation	PSLYPPPRR------ CCCCCCCCC------	63.82	115383407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
722	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN609_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN609_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
EXOC5_HUMAN	EXOC5	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN609_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467; SER-576; SER-578;SER-842; SER-849 AND SER-1055, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-381; SER-467; SER-470;SER-560; THR-566; THR-746; SER-804; SER-842; TYR-845; SER-846; SER-849AND SER-1055, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358; SER-576; SER-578;SER-842; SER-846; SER-849 AND SER-1055, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576; SER-578; SER-842;SER-846 AND SER-849, AND MASS SPECTROMETRY.	17081983 [Abstract]