WT1_HUMAN - dbPTM
WT1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WT1_HUMAN
UniProt AC P19544
Protein Name Wilms tumor protein
Gene Name WT1
Organism Homo sapiens (Human).
Sequence Length 449
Subcellular Localization Nucleus . Nucleus, nucleolus. Cytoplasm. Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm.
Isoform 1: Nucleus speckle .
Isoform 4: Nucleus, nucleoplasm .
Protein Description Transcription factor that plays an important role in cellular development and cell survival. [PubMed: 7862533 Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3']
Protein Sequence MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
54 (in isoform 8)Phosphorylation-39.53-
54 (in isoform 7)Phosphorylation-39.53-
62PhosphorylationAPPPAPPPPPPPPPH
CCCCCCCCCCCCCCC		53.6327251275
67 (in isoform 8)Phosphorylation-45.0427251275
67 (in isoform 7)Phosphorylation-45.0427251275
69 (in isoform 8)Phosphorylation-40.9125262027
69 (in isoform 7)Phosphorylation-40.9125262027
70PhosphorylationPPPPPPHSFIKQEPS
CCCCCCCCCCCCCCC		34.1524719451
71PhosphorylationPPPPPHSFIKQEPSW
CCCCCCCCCCCCCCC		8.0124719451
73SumoylationPPPHSFIKQEPSWGG
CCCCCCCCCCCCCCC		46.7415520190
73SumoylationPPPHSFIKQEPSWGG
CCCCCCCCCCCCCCC		46.74-
76 (in isoform 8)Phosphorylation-32.6524719451
76 (in isoform 7)Phosphorylation-32.6524719451
107 (in isoform 9)Phosphorylation-3.1727732954
108 (in isoform 9)Phosphorylation-38.6223684312
110 (in isoform 9)Phosphorylation-7.5426434776
112 (in isoform 9)Phosphorylation-23.2623684312
116 (in isoform 9)Phosphorylation-44.2926434776
117 (in isoform 9)Phosphorylation-44.8626434776
125 (in isoform 9)Phosphorylation-14.3927732954
141SumoylationLPSCLESQPAIRNQG
CHHHHHCCCCHHCCC		23.28-
177SumoylationQFPNHSFKHEDPMGQ
CCCCCCCCCCCCCCC		49.45-
177SumoylationQFPNHSFKHEDPMGQ
CCCCCCCCCCCCCCC		49.4515520190
245SumoylationWNQMNLGATLKGVAA
CCCCCCCCEEEEECC		16.96-
251 (in isoform 3)Phosphorylation-18.1227732954
251 (in isoform 2)Phosphorylation-18.1227732954
252 (in isoform 3)Phosphorylation-18.9223684312
252 (in isoform 2)Phosphorylation-18.9223684312
254 (in isoform 3)Phosphorylation-23.4826434776
254 (in isoform 2)Phosphorylation-23.4826434776
256 (in isoform 3)Phosphorylation-40.6323684312
256 (in isoform 2)Phosphorylation-40.6323684312
260 (in isoform 3)Phosphorylation-9.4926434776
260 (in isoform 2)Phosphorylation-9.4926434776
260 (in isoform 6)Phosphorylation-9.49-
261 (in isoform 2)Phosphorylation-25.2326434776
261 (in isoform 3)Phosphorylation-25.2326434776
261PhosphorylationSSSSVKWTEGQSNHS
CCCCCEECCCCCCCC		25.2322115753
262 (in isoform 6)Phosphorylation-54.87-
265PhosphorylationVKWTEGQSNHSTGYE
CEECCCCCCCCCCCC		47.5724247654
268PhosphorylationTEGQSNHSTGYESDN
CCCCCCCCCCCCCCC		27.9822115753
269PhosphorylationEGQSNHSTGYESDNH
CCCCCCCCCCCCCCC		35.9128348404
269 (in isoform 3)Phosphorylation-35.9127732954
269 (in isoform 2)Phosphorylation-35.9127732954
271PhosphorylationQSNHSTGYESDNHTT
CCCCCCCCCCCCCCC		16.6122115753
273PhosphorylationNHSTGYESDNHTTPI
CCCCCCCCCCCCCCE		34.9224247654
277PhosphorylationGYESDNHTTPILCGA
CCCCCCCCCCEEECE		40.2922115753
278PhosphorylationYESDNHTTPILCGAQ
CCCCCCCCCEEECEE		10.7722115753
295MethylationIHTHGVFRGIQDVRR
EECCCHHCCHHHHHC		38.61115920097
309PhosphorylationRVPGVAPTLVRSASE
CCCCCCCHHHHCCCC		28.3125072903
313PhosphorylationVAPTLVRSASETSEK
CCCHHHHCCCCCCCC		28.7725072903
315PhosphorylationPTLVRSASETSEKRP
CHHHHCCCCCCCCCC		42.5325072903
317PhosphorylationLVRSASETSEKRPFM
HHHCCCCCCCCCCCC		39.4225072903
318PhosphorylationVRSASETSEKRPFMC
HHCCCCCCCCCCCCC		36.7525072903
324 (in isoform 8)Phosphorylation-1.1027732954
325 (in isoform 8)Phosphorylation-3.1623684312
327 (in isoform 8)Phosphorylation-8.6726434776
329 (in isoform 8)Phosphorylation-18.2323684312
333 (in isoform 8)Phosphorylation-28.2926434776
334 (in isoform 8)Phosphorylation-13.4826434776
341PhosphorylationYFKLSHLQMHSRKHT
HEEHHHHHHCCCCCC		23.3224719451
342 (in isoform 8)Phosphorylation-3.7927732954
348PhosphorylationQMHSRKHTGEKPYQC
HHCCCCCCCCCCCCC		50.5023532336
363MethylationDFKDCERRFSRSDQL
CHHHHHHHCCCHHHH		16.17-
365PhosphorylationKDCERRFSRSDQLKR
HHHHHHCCCHHHHHH		29.1211237525
386PhosphorylationGVKPFQCKTCQRKFS
CCCCCCCCHHCCCCC		41.3724719451
387 (in isoform 2)Phosphorylation-22.84-
389 (in isoform 2)Phosphorylation-57.75-
393PhosphorylationKTCQRKFSRSDHLKT
CHHCCCCCCCHHHCE		33.6311237525
404 (in isoform 4)Phosphorylation-25.58-
406 (in isoform 4)Phosphorylation-39.50-
428PhosphorylationCQKKFARSDELVRHH
HHHHHHCCHHHHHHH		31.82-
433PhosphorylationARSDELVRHHNMHQR
HCCHHHHHHHHHHHH		37.669366517
444SumoylationMHQRNMTKLQLAL--
HHHHHCCHHHHCC--		24.3828112733
461Phosphorylation-------------------
-------------------		9366517
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
67SPhosphorylationKinaseAKT1P31749
PSP
365SPhosphorylationKinasePRKACAP17612
GPS
365SPhosphorylationKinasePKA-FAMILY-GPS
365SPhosphorylationKinasePKA_GROUP-PhosphoELM
393SPhosphorylationKinasePRKACAP17612
GPS
393SPhosphorylationKinasePKA-FAMILY-GPS
393SPhosphorylationKinasePKA_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WT1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WT1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FL2D_HUMANWTAPphysical
11001926
UBC9_HUMANUBE2Iphysical
8798754
PAWR_HUMANPAWRphysical
8943350
P53_HUMANTP53physical
8389468
MEN1_HUMANMEN1physical
21378168
SUZ12_HUMANSUZ12physical
21378168
EZH2_HUMANEZH2physical
21378168
DNMT1_HUMANDNMT1physical
21378168
DVL3_HUMANDVL3physical
21900206
NPM3_HUMANNPM3physical
21900206
ZN205_HUMANZNF205physical
21900206
TAOK1_HUMANTAOK1physical
21900206
HSP74_HUMANHSPA4physical
9553041
CIAO1_HUMANCIAO1physical
9556563
DVL3_HUMANDVL3physical
19447967
EGR1_HUMANEGR1physical
19067769
K1C40_HUMANKRT40physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
CASZ1_HUMANCASZ1physical
25640309
CCL5_HUMANCCL5physical
25640309
DIRA3_HUMANDIRAS3physical
25640309
KLK7_HUMANKLK7physical
25640309
ARY2_HUMANNAT2physical
25640309
THRSP_HUMANTHRSPphysical
25640309
CC136_HUMANCCDC136physical
27229929
CCD33_HUMANCCDC33physical
27229929
CEP70_HUMANCEP70physical
27229929
DVL2_HUMANDVL2physical
27229929
DVL3_HUMANDVL3physical
27229929
ETV7_HUMANETV7physical
27229929
FAM9B_HUMANFAM9Bphysical
27229929
FMR1N_HUMANFMR1NBphysical
27229929
GOGA2_HUMANGOLGA2physical
27229929
HMBX1_HUMANHMBOX1physical
27229929
IDI1_HUMANIDI1physical
27229929
IMA3_HUMANKPNA4physical
27229929
IMA6_HUMANKPNA5physical
27229929
KR101_HUMANKRTAP10-1physical
27229929
KR103_HUMANKRTAP10-3physical
27229929
KR107_HUMANKRTAP10-7physical
27229929
KR109_HUMANKRTAP10-9physical
27229929
LDOC1_HUMANLDOC1physical
27229929
MAGA8_HUMANMAGEA8physical
27229929
RNH2B_HUMANRNASEH2Bphysical
27229929
SERF2_HUMANSERF2physical
27229929
THAP1_HUMANTHAP1physical
27229929
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
136680Frasier syndrome (FS)
194070Wilms tumor 1 (WT1)
194080Denys-Drash syndrome (DDS)
256370Nephrotic syndrome 4 (NPHS4)
608978Meacham syndrome (MEACHS)
Note=A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11
22)(p13
q12) with EWSR1.
156240
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WT1_HUMAN

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Related Literatures of Post-Translational Modification
Sumoylation
ReferencePubMed
"SUMO-1 modification of the Wilms' tumor suppressor WT1.";
Smolen G.A., Vassileva M.T., Wells J., Matunis M.J., Haber D.A.;
Cancer Res. 64:7846-7851(2004).
Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-73 AND LYS-177, ANDSUMOYLATION AT LYS-73 AND LYS-177.

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