KLK7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK7_HUMAN
• UniProt AC: P49862
• Protein Name: Kallikrein-7
• Gene Name: KLK7
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Secreted . In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
• Protein Description: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines..
• Protein Sequence: MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	RAQRIKASKSFRHPG HHHHHHHCCCCCCCC	24.67	28634298
98	Phosphorylation	QRIKASKSFRHPGYS HHHHHCCCCCCCCCC	25.64	28634298
104	Phosphorylation	KSFRHPGYSTQTHVN CCCCCCCCCCCCCCC	17.00	28634298
105	Phosphorylation	SFRHPGYSTQTHVND CCCCCCCCCCCCCCC	21.69	28634298
106	Phosphorylation	FRHPGYSTQTHVNDL CCCCCCCCCCCCCCE	29.07	28634298
108	Phosphorylation	HPGYSTQTHVNDLML CCCCCCCCCCCCEEE	28.07	28634298
120	Phosphorylation	LMLVKLNSQARLSSM EEEEECCCHHHHHHH	35.34	-
125	Phosphorylation	LNSQARLSSMVKKVR CCCHHHHHHHHHHCC	15.72	-
161	Phosphorylation	SPDVTFPSDLMCVDV CCCCCCCCCCEEEEE	38.90	-
187	Phosphorylation	YKDLLENSMLCAGIP HHHHHHCCCCCCCCC	12.08	20068231
196	Phosphorylation	LCAGIPDSKKNACNG CCCCCCCCCCCCCCC	39.93	20068231
246	N-linked_Glycosylation	CKFTKWINDTMKKHR HHHHHHHHHHHHHCC	37.27	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDSN_HUMAN	CDSN	physical	15140227
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.