CCL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCL5_HUMAN
• UniProt AC: P13501
• Protein Name: C-C motif chemokine 5
• Gene Name: CCL5
• Organism: Homo sapiens (Human).
• Sequence Length: 91
• Subcellular Localization: Secreted.
• Protein Description: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. [PubMed: 16791620]
• Protein Sequence: MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LAVILIATALCAPAS HHHHHHHHHHHCCCC	17.11	25332170
26	Phosphorylation	APASASPYSSDTTPC CCCCCCCCCCCCCCC	20.50	25332170
27	O-linked_Glycosylation	PASASPYSSDTTPCC CCCCCCCCCCCCCCC	25.73	1380064
27	O-linked_Glycosylation	PASASPYSSDTTPCC CCCCCCCCCCCCCCC	25.73	1380064
27	Phosphorylation	PASASPYSSDTTPCC CCCCCCCCCCCCCCC	25.73	25332170
28	O-linked_Glycosylation	ASASPYSSDTTPCCF CCCCCCCCCCCCCCH	32.88	1380064
28	O-linked_Glycosylation	ASASPYSSDTTPCCF CCCCCCCCCCCCCCH	32.88	1380064
68	Ubiquitination	AVVFVTRKNRQVCAN EEEEEEECCCCEECC	47.30	-
90	Methionine sulfoxide	EYINSLEMS------ HHHHHHCCC------	7.55	-
90	Oxidation	EYINSLEMS------ HHHHHHCCC------	7.55	1380064

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCL5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCL5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCL5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDC1_HUMAN	SDC1	physical	14637022
SDC4_HUMAN	SDC4	physical	14637022
CCR5_HUMAN	CCR5	physical	14637022
IL8_HUMAN	CXCL8	physical	11509627
CCL2_HUMAN	CCL2	genetic	11350939
CCR1_HUMAN	CCR1	physical	11449371
CCR3_HUMAN	CCR3	physical	11449371
CCR5_HUMAN	CCR5	physical	11449371
CCR1_HUMAN	CCR1	physical	11116158
CCR5_HUMAN	CCR5	physical	11116158
TRIP6_HUMAN	TRIP6	physical	21988832
GTR5_HUMAN	SLC2A5	physical	21988832
RAGP1_HUMAN	RANGAP1	physical	21988832
TF65_HUMAN	RELA	physical	21988832
EDC4_HUMAN	EDC4	physical	21988832
CO4A_HUMAN	C4A	physical	28514442
NTM1A_HUMAN	NTMT1	physical	28514442
SPT20_HUMAN	SPATA20	physical	28514442
KAD4_HUMAN	AK4	physical	28514442
UBAC1_HUMAN	UBAC1	physical	28514442
SPRY4_HUMAN	SPRYD4	physical	28514442
GPD1L_HUMAN	GPD1L	physical	28514442
S10AD_HUMAN	S100A13	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Cytokine RANTES released by thrombin-stimulated platelets is a potentattractant for human eosinophils.";
Kameyoshi Y., Doerschner A., Mallet A.I., Christophers E.,Schroeder J.-M.;
J. Exp. Med. 176:587-592(1992).
Cited for: PROTEIN SEQUENCE OF 24-55, FUNCTION, MASS SPECTROMETRY, GLYCOSYLATIONAT SER-27 AND SER-28, AND OXIDATION AT MET-90.
PubMed: 1380064