CCR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCR1_HUMAN
• UniProt AC: P32246
• Protein Name: C-C chemokine receptor type 1
• Gene Name: CCR1
• Organism: Homo sapiens (Human).
• Sequence Length: 355
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation..
• Protein Sequence: METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	N-linked_Glycosylation	---METPNTTEDYDT ---CCCCCCCCCCCC	68.03	UniProtKB CARBOHYD
10	Sulfation	TPNTTEDYDTTTEFD CCCCCCCCCCCCCCC	14.68	-
18	Sulfation	DTTTEFDYGDATPCQ CCCCCCCCCCCCCCH	23.40	17558413
18	Sulfation	DTTTEFDYGDATPCQ CCCCCCCCCCCCCCH	23.40	-
41	Phosphorylation	AQLLPPLYSLVFVIG HHHHHHHHHHHHHHH	13.01	17384208
132	Phosphorylation	ILLTIDRYLAIVHAV HHHHHHHHHHHHHHH	9.20	9058802
165	Phosphorylation	WALAILASMPGLYFS HHHHHHHHCCCCCCC	23.28	30257219
170	Phosphorylation	LASMPGLYFSKTQWE HHHCCCCCCCCCCEE	16.24	30257219
172	Phosphorylation	SMPGLYFSKTQWEFT HCCCCCCCCCCEEEC	22.64	30257219
326	Ubiquitination	RVAVHLVKWLPFLSV HHHHHHHHHHHHCCH	49.74	-
332	Phosphorylation	VKWLPFLSVDRLERV HHHHHHCCHHHHHHC	23.50	28348404
340	Phosphorylation	VDRLERVSSTSPSTG HHHHHHCCCCCCCCC	33.83	29978859
341	Phosphorylation	DRLERVSSTSPSTGE HHHHHCCCCCCCCCC	30.01	29978859
342	Phosphorylation	RLERVSSTSPSTGEH HHHHCCCCCCCCCCC	36.83	29978859
343	Phosphorylation	LERVSSTSPSTGEHE HHHCCCCCCCCCCCC	20.85	29978859
345	Phosphorylation	RVSSTSPSTGEHELS HCCCCCCCCCCCCCC	49.14	29978859
346	Phosphorylation	VSSTSPSTGEHELSA CCCCCCCCCCCCCCC	50.39	29978859
352	Phosphorylation	STGEHELSAGF---- CCCCCCCCCCC----	24.30	28355574

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCR1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCL7_HUMAN	CCL7	physical	8530354
PHAG1_HUMAN	PAG1	physical	26186194
NEUM_HUMAN	GAP43	physical	26186194
GBG10_HUMAN	GNG10	physical	26186194
YES_HUMAN	YES1	physical	26186194
EPHA2_HUMAN	EPHA2	physical	26186194
SETD7_HUMAN	SETD7	physical	26186194
GNA13_HUMAN	GNA13	physical	26186194
GNAQ_HUMAN	GNAQ	physical	26186194
LENG1_HUMAN	LENG1	physical	26186194
LTOR4_HUMAN	LAMTOR4	physical	26186194
OCC1_HUMAN	C12orf75	physical	28514442
GBG10_HUMAN	GNG10	physical	28514442
PHAG1_HUMAN	PAG1	physical	28514442
NEUM_HUMAN	GAP43	physical	28514442
EPHA2_HUMAN	EPHA2	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
LENG1_HUMAN	LENG1	physical	28514442
STXB2_HUMAN	STXBP2	physical	28514442
YES_HUMAN	YES1	physical	28514442
CDCA3_HUMAN	CDCA3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.