STXB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STXB2_HUMAN
• UniProt AC: Q15833
• Protein Name: Syntaxin-binding protein 2
• Gene Name: STXBP2
• Organism: Homo sapiens (Human).
• Sequence Length: 593
• Protein Description: Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells..
• Protein Sequence: MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIKDFQGTPTFTYKAAHIFFTDTCPEPLFSELGRSRLAKVVKTLKEIHLAFLPYEAQVFSLDAPHSTYNLYCPFRAEERTRQLEVLAQQIATLCATLQEYPAIRYRKGPEDTAQLAHAVLAKLNAFKADTPSLGEGPEKTRSQLLIMDRAADPVSPLLHELTFQAMAYDLLDIEQDTYRYETTGLSEAREKAVLLDEDDDLWVELRHMHIADVSKKVTELLRTFCESKRLTTDKANIKDLSQILKKMPQYQKELNKYSTHLHLADDCMKHFKGSVEKLCSVEQDLAMGSDAEGEKIKDSMKLIVPVLLDAAVPAYDKIRVLLLYILLRNGVSEENLAKLIQHANVQAHSSLIRNLEQLGGTVTNPGGSGTSSRLEPRERMEPTYQLSRWTPVIKDVMEDAVEDRLDRNLWPFVSDPAPTASSQAAVSARFGHWHKNKAGIEARAGPRLIVYVMGGVAMSEMRAAYEVTRATEGKWEVLIGSSHILTPTRFLDDLKALDKKLEDIALP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MAPSGLKAVVGEKI -CCCCCHHHHHHHHH	42.53	-
7	Methylation	-MAPSGLKAVVGEKI -CCCCCHHHHHHHHH	42.53	115980385
7	Ubiquitination	-MAPSGLKAVVGEKI -CCCCCHHHHHHHHH	42.53	-
13	Ubiquitination	LKAVVGEKILSGVIR HHHHHHHHHHHHHHH	42.91	21906983
13	Acetylation	LKAVVGEKILSGVIR HHHHHHHHHHHHHHH	42.91	25953088
13	Ubiquitination	LKAVVGEKILSGVIR HHHHHHHHHHHHHHH	42.91	21890473
13 (in isoform 2)	Ubiquitination	-	42.91	-
13	Ubiquitination	LKAVVGEKILSGVIR HHHHHHHHHHHHHHH	42.91	21890473
16	Phosphorylation	VVGEKILSGVIRSVK HHHHHHHHHHHHHCC	34.19	21406692
21	Phosphorylation	ILSGVIRSVKKDGEW HHHHHHHHCCCCCCE	27.45	23312004
63	Ubiquitination	TIVEDINKRREPIPS EEEECHHHCCCCCCC	53.84	-
63	Ubiquitination	TIVEDINKRREPIPS EEEECHHHCCCCCCC	53.84	-
70	Phosphorylation	KRREPIPSLEAIYLL HCCCCCCCCEEEEEC	39.29	24719451
75	Phosphorylation	IPSLEAIYLLSPTEK CCCCEEEEECCCCHH	14.50	24719451
78	Phosphorylation	LEAIYLLSPTEKSVQ CEEEEECCCCHHHHH	27.47	26074081
80	Phosphorylation	AIYLLSPTEKSVQAL EEEECCCCHHHHHHH	53.31	25072903
89	Ubiquitination	KSVQALIKDFQGTPT HHHHHHHHHHCCCCC	54.03	890473
94	Phosphorylation	LIKDFQGTPTFTYKA HHHHHCCCCCEEEEE	14.36	21815630
96	Phosphorylation	KDFQGTPTFTYKAAH HHHCCCCCEEEEEEE	28.57	23186163
98	Phosphorylation	FQGTPTFTYKAAHIF HCCCCCEEEEEEEEE	26.96	23186163
100	Ubiquitination	GTPTFTYKAAHIFFT CCCCEEEEEEEEEEE	35.72	21906983
100	Ubiquitination	GTPTFTYKAAHIFFT CCCCEEEEEEEEEEE	35.72	-
110	Glutathionylation	HIFFTDTCPEPLFSE EEEEECCCCCHHHHH	3.91	22555962
190 (in isoform 2)	Ubiquitination	-	27.58	-
193	Ubiquitination	YPAIRYRKGPEDTAQ CCCHHCCCCHHHHHH	70.64	21906983
204	Ubiquitination	DTAQLAHAVLAKLNA HHHHHHHHHHHHHHC	7.75	-
204	Ubiquitination	DTAQLAHAVLAKLNA HHHHHHHHHHHHHHC	7.75	21890473
205 (in isoform 2)	Ubiquitination	-	3.71	-
205	Ubiquitination	TAQLAHAVLAKLNAF HHHHHHHHHHHHHCC	3.71	21890473
208	Ubiquitination	LAHAVLAKLNAFKAD HHHHHHHHHHCCCCC	37.81	21890473
210 (in isoform 2)	Ubiquitination	-	42.50	-
213	Ubiquitination	LAKLNAFKADTPSLG HHHHHCCCCCCCCCC	42.83	21906983
216	Phosphorylation	LNAFKADTPSLGEGP HHCCCCCCCCCCCCC	21.45	25159151
218	Phosphorylation	AFKADTPSLGEGPEK CCCCCCCCCCCCCCC	51.61	25159151
219	Ubiquitination	FKADTPSLGEGPEKT CCCCCCCCCCCCCCH	8.35	-
219	Ubiquitination	FKADTPSLGEGPEKT CCCCCCCCCCCCCCH	8.35	21890473
224	Ubiquitination	PSLGEGPEKTRSQLL CCCCCCCCCHHHHEE	77.30	21906983
224	Ubiquitination	PSLGEGPEKTRSQLL CCCCCCCCCHHHHEE	77.30	21890473
225	Ubiquitination	SLGEGPEKTRSQLLI CCCCCCCCHHHHEEE	52.99	21906983
226	Phosphorylation	LGEGPEKTRSQLLIM CCCCCCCHHHHEEEE	33.61	18452278
227	Phosphorylation	GEGPEKTRSQLLIMD CCCCCCHHHHEEEEE	33.21	27251275
233	Sulfoxidation	TRSQLLIMDRAADPV HHHHEEEEECCCCCC	2.62	21406390
236	Ubiquitination	QLLIMDRAADPVSPL HEEEEECCCCCCHHH	16.38	21906983
236	Ubiquitination	QLLIMDRAADPVSPL HEEEEECCCCCCHHH	16.38	21890473
266	Phosphorylation	IEQDTYRYETTGLSE CCCCCCEEECCCCHH	13.76	22817900
301	Ubiquitination	MHIADVSKKVTELLR HCHHHHHHHHHHHHH	51.62	-
302	Ubiquitination	HIADVSKKVTELLRT CHHHHHHHHHHHHHH	47.05	-
304	O-linked_Glycosylation	ADVSKKVTELLRTFC HHHHHHHHHHHHHHH	29.78	30379171
312	Ubiquitination	ELLRTFCESKRLTTD HHHHHHHHHCCCCCC	55.92	-
313	Ubiquitination	LLRTFCESKRLTTDK HHHHHHHHCCCCCCC	25.02	-
317	Ubiquitination	FCESKRLTTDKANIK HHHHCCCCCCCCCHH	36.66	21890473
320	Ubiquitination	SKRLTTDKANIKDLS HCCCCCCCCCHHHHH	41.04	21890473
321 (in isoform 2)	Ubiquitination	-	26.28	-
321	Ubiquitination	KRLTTDKANIKDLSQ CCCCCCCCCHHHHHH	26.28	21890473
324	Ubiquitination	TTDKANIKDLSQILK CCCCCCHHHHHHHHH	53.04	21890473
327	Phosphorylation	KANIKDLSQILKKMP CCCHHHHHHHHHHCH	25.88	23403867
331	Ubiquitination	KDLSQILKKMPQYQK HHHHHHHHHCHHHHH	48.97	-
331	Ubiquitination	KDLSQILKKMPQYQK HHHHHHHHHCHHHHH	48.97	-
332	Ubiquitination	DLSQILKKMPQYQKE HHHHHHHHCHHHHHH	52.98	-
335	Ubiquitination	QILKKMPQYQKELNK HHHHHCHHHHHHHHH	50.19	21906983
335	Ubiquitination	QILKKMPQYQKELNK HHHHHCHHHHHHHHH	50.19	21890473
336	Phosphorylation	ILKKMPQYQKELNKY HHHHCHHHHHHHHHC	18.71	-
338	Acetylation	KKMPQYQKELNKYST HHCHHHHHHHHHCCC	60.27	27452117
338	Ubiquitination	KKMPQYQKELNKYST HHCHHHHHHHHHCCC	60.27	-
342	Ubiquitination	QYQKELNKYSTHLHL HHHHHHHHCCCHHHH	53.88	-
342	Ubiquitination	QYQKELNKYSTHLHL HHHHHHHHCCCHHHH	53.88	-
343	Ubiquitination	YQKELNKYSTHLHLA HHHHHHHCCCHHHHH	20.09	-
355	Ubiquitination	HLADDCMKHFKGSVE HHHHHHHHHHCHHHH	52.82	-
358	Ubiquitination	DDCMKHFKGSVEKLC HHHHHHHCHHHHHHH	50.42	-
360	Phosphorylation	CMKHFKGSVEKLCSV HHHHHCHHHHHHHCH	27.91	28857561
366	Phosphorylation	GSVEKLCSVEQDLAM HHHHHHHCHHHHHCC	38.84	20873877
371	Phosphorylation	LCSVEQDLAMGSDAE HHCHHHHHCCCCCCC	3.36	27251275
375	Phosphorylation	EQDLAMGSDAEGEKI HHHHCCCCCCCCCCH	22.14	20873877
401	Phosphorylation	LDAAVPAYDKIRVLL HHHCCCHHHHHHHHH	16.23	-
403	Ubiquitination	AAVPAYDKIRVLLLY HCCCHHHHHHHHHHH	21.53	-
410	Phosphorylation	KIRVLLLYILLRNGV HHHHHHHHHHHHCCC	6.90	28442448
414	Ubiquitination	LLLYILLRNGVSEEN HHHHHHHHCCCCHHH	34.12	-
435	Phosphorylation	HANVQAHSSLIRNLE HHHHHHHHHHHHHHH	29.83	28270605
436	Phosphorylation	ANVQAHSSLIRNLEQ HHHHHHHHHHHHHHH	20.25	24719451
447	Phosphorylation	NLEQLGGTVTNPGGS HHHHHCCEEECCCCC	23.51	23663014
449	Phosphorylation	EQLGGTVTNPGGSGT HHHCCEEECCCCCCC	35.22	23663014
454	Phosphorylation	TVTNPGGSGTSSRLE EEECCCCCCCCCCCC	44.83	23663014
456	Phosphorylation	TNPGGSGTSSRLEPR ECCCCCCCCCCCCCC	25.81	23663014
457	Phosphorylation	NPGGSGTSSRLEPRE CCCCCCCCCCCCCCH	19.58	23663014
458	Phosphorylation	PGGSGTSSRLEPRER CCCCCCCCCCCCCHH	40.50	23663014
469	Phosphorylation	PRERMEPTYQLSRWT CCHHCCCCCHHHCCC	15.59	22210691
473	Phosphorylation	MEPTYQLSRWTPVIK CCCCCHHHCCCHHHH	15.39	22210691
480	Ubiquitination	SRWTPVIKDVMEDAV HCCCHHHHHHHHHHH	44.50	21906983
490	Methylation	MEDAVEDRLDRNLWP HHHHHHHCCHHCCCC	25.61	115917993
491	Ubiquitination	EDAVEDRLDRNLWPF HHHHHHCCHHCCCCC	12.87	-
491	Ubiquitination	EDAVEDRLDRNLWPF HHHHHHCCHHCCCCC	12.87	21890473
505	Phosphorylation	FVSDPAPTASSQAAV CCCCCCCCCCCHHHH	41.08	28348404
507	Phosphorylation	SDPAPTASSQAAVSA CCCCCCCCCHHHHHH	26.01	28348404
508	Phosphorylation	DPAPTASSQAAVSAR CCCCCCCCHHHHHHH	22.75	28348404
513	Phosphorylation	ASSQAAVSARFGHWH CCCHHHHHHHHCCCC	14.70	27535140
521	Ubiquitination	ARFGHWHKNKAGIEA HHHCCCCCCHHCCCC	55.76	-
529	Methylation	NKAGIEARAGPRLIV CHHCCCCCCCCEEEE	27.56	115386647
551	Phosphorylation	MSEMRAAYEVTRATE HHHHHHHHHHHHHCC	15.22	24043423
554	Phosphorylation	MRAAYEVTRATEGKW HHHHHHHHHHCCCCE	11.57	24043423
557 (in isoform 2)	Ubiquitination	-	41.81	-
557	Ubiquitination	AYEVTRATEGKWEVL HHHHHHHCCCCEEEE	41.81	21890473
560	Ubiquitination	VTRATEGKWEVLIGS HHHHCCCCEEEEECC	33.67	21890473
571	Ubiquitination	LIGSSHILTPTRFLD EECCCCCCCCHHHHH	3.82	-
572	Phosphorylation	IGSSHILTPTRFLDD ECCCCCCCCHHHHHH	23.24	22817900
578 (in isoform 2)	Ubiquitination	-	57.39	-
581	Ubiquitination	TRFLDDLKALDKKLE HHHHHHHHHHHHHHH	54.63	2190698
585	Acetylation	DDLKALDKKLEDIAL HHHHHHHHHHHHHCC	61.17	7491931
586	Acetylation	DLKALDKKLEDIALP HHHHHHHHHHHHCCC	57.69	7491941
586	Ubiquitination	DLKALDKKLEDIALP HHHHHHHHHHHHCCC	57.69	-
592	Ubiquitination	KKLEDIALP------ HHHHHHCCC------	5.44	21906983
592	Ubiquitination	KKLEDIALP------ HHHHHHCCC------	5.44	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
572	T	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STXB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STXB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APT_HUMAN	APRT	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613101: Familial hemophagocytic lymphohistiocytosis 5 (FHL5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.